Why Do Antidepressants Take So Long To Work?

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Are you prescribed with antidepressants? And you don't find any difference even after taking those medicines for more than a week, It's frustrating right? You might be thinking that the doctor has prescribed you with wrong medicine or the medicine doesn't work.

But, that is not the case! Antidepressants work in totally different way than other pain or sleep medicines.

Let's look for an example!

Have you noticed when your water tanker runs out of water, you turn on the motor to fill it with water. As soon as you switch on the motor, you don't get water in the taps immediately. Why? Because it takes time for water to reach the level to supply it into taps.

Similarly, when you take antidepressants, they need time to build up in your body before it can show it effect properly, which can take around 2-6 weeks for various antidepressants.

There are few more reasons why these medicines take so much of time to work.

Number 1.

Antidepressants get build up in a specific part of the cell membrane, which helps, more signals to pass through the brain, when brain finds about serotonin entering in body, it stops making more serotonin that cause decrease in level of serotonin and when the serotonin reaches a steady level in the brain, gradually the level increases in the brain, which improves the symptoms of depression.

Number 2:

Antidepressants change the process of how the brain cells work, leading to increase in chemicals like serotonin in the brain.

Number 3. :

Antidepressants also help our brain in making new cell connections which takes weeks to show their effect.

Source:-Samuel J. Erb, Jeffrey M. Schappi, Mark M. Rasenick. Antidepressants Accumulate in Lipid Rafts Independent of Monoamine Transporters to Modulate Redistribution of the G protein, Gαs. Journal of Biological Chemistry, 2016; jbc.M116.727263 DOI: 10.1074/jbc.M116.727263

Disclaimer:-This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment.Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.

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Disclaimer:

This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment. Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.

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