Domperidone + Paracetamol
Find more information about this combination medication at the webpages for domperidone and paracetamol
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Domperidone is used to relieve nausea and vomiting, which are symptoms of an upset stomach. Paracetamol is used to reduce fever and relieve mild to moderate pain, which refers to discomfort caused by various conditions. Both medications help alleviate symptoms but target different issues: Domperidone focuses on gastrointestinal symptoms, while Paracetamol addresses general pain and fever.
Domperidone works by blocking dopamine receptors, which are parts of the brain that trigger nausea and vomiting, helping the stomach empty more quickly. Paracetamol reduces the production of prostaglandins, which are chemicals in the body that cause pain and inflammation, providing pain and fever relief. Both medications are effective but act on different systems: Domperidone targets the digestive system, while Paracetamol targets the central nervous system.
Domperidone is usually taken orally at a dose of 10 milligrams up to three times a day, ideally before meals. Paracetamol is also taken orally, with a typical adult dose of 500 to 1000 milligrams every four to six hours, not exceeding 4000 milligrams in 24 hours. Both medications are generally well-tolerated when taken as directed, but it's important to follow dosage instructions to avoid side effects.
Domperidone can cause side effects like dry mouth, headache, and dizziness, with a significant risk of irregular heartbeat, which refers to an abnormal heart rhythm. Paracetamol is generally well-tolerated but can cause nausea and rash, with a significant risk of liver damage, which refers to harm to the liver cells, especially when taken in high doses. Both medications can cause nausea as a side effect.
Domperidone should be used with caution in people with heart conditions or those taking medications affecting heart rhythm. Paracetamol should be used cautiously in people with liver disease or those consuming large amounts of alcohol, as it can cause liver damage. Both medications should be used with caution in people with kidney problems. It's important to follow recommended dosages and consult a healthcare provider if you have any underlying health conditions.
Indications and Purpose
How does combination of Domperidone and Paracetamol work?
Domperidone works by blocking dopamine receptors, which are proteins in the brain that help transmit signals. This action helps to increase the movement of the stomach and intestines, making it easier for food to pass through the stomach. It is often used to relieve nausea and vomiting. Paracetamol, on the other hand, works by reducing the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. It is commonly used to relieve mild to moderate pain and reduce fever. Both Domperidone and Paracetamol are used to alleviate discomfort, but they do so in different ways. Domperidone targets the digestive system, while Paracetamol targets pain and fever. They share the common goal of improving comfort and well-being, but they act on different systems within the body.
How effective is combination of Domperidone and Paracetamol?
Domperidone is a medication used to relieve nausea and vomiting, which are symptoms of feeling sick and throwing up. It works by blocking dopamine receptors, which are parts of the brain that can trigger nausea. Paracetamol, on the other hand, is a pain reliever and fever reducer, which means it helps to ease pain and lower high body temperature. It works by blocking the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. Both Domperidone and Paracetamol are effective in their own ways. Domperidone is particularly useful for stomach-related issues, while Paracetamol is widely used for general pain and fever. They share the common attribute of providing relief from discomfort, but they target different symptoms. Together, they can be used to manage a range of symptoms, making them versatile in treating various conditions.
Directions for Use
What is the usual dose of combination of Domperidone and Paracetamol?
The usual adult daily dose for domperidone, which is a medicine used to relieve nausea and vomiting, is typically 10 milligrams taken up to three times a day. For paracetamol, which is a medicine used to relieve pain and reduce fever, the usual adult dose is 500 to 1000 milligrams every four to six hours, not exceeding 4000 milligrams in 24 hours. Domperidone works by blocking dopamine receptors, which are parts of the brain that trigger nausea and vomiting. Paracetamol works by reducing the production of prostaglandins, which are chemicals in the body that cause pain and fever. Both medicines are taken orally and are used to relieve symptoms, but they target different issues. Domperidone is more focused on gastrointestinal symptoms, while paracetamol is used for general pain and fever relief. Both should be used as directed to avoid side effects.
How does one take combination of Domperidone and Paracetamol?
Domperidone, which is used to relieve nausea and vomiting, should be taken before meals. This is because it works best when taken on an empty stomach. Paracetamol, which is used to relieve pain and reduce fever, can be taken with or without food. There are no specific food restrictions for either medicine, but it's important to follow the dosage instructions provided by your healthcare provider. Both medicines are generally well-tolerated, but they should be used with caution in people with certain medical conditions. It's important to avoid alcohol while taking these medicines, as it can increase the risk of side effects. Always consult with a healthcare professional if you have any concerns or questions about taking these medications.
For how long is combination of Domperidone and Paracetamol taken?
Domperidone is typically used for short-term relief, often for a few days, to treat nausea and vomiting, which are symptoms of feeling sick and throwing up. It works by speeding up the movement of the stomach and intestines, helping to move food through the stomach more quickly. Paracetamol, on the other hand, is commonly used for pain relief and to reduce fever, which is a high body temperature. It can be used for both short-term and long-term treatment, depending on the condition being treated. Both medicines are taken orally, which means by mouth, and are generally well-tolerated when used as directed. They share the common attribute of being used to relieve symptoms, but they target different symptoms and have different mechanisms of action, which means the way they work in the body.
How long does it take for combination of Domperidone and Paracetamol to work?
The combination medicine typically starts working within 30 minutes to an hour. This is because it contains two active ingredients: ibuprofen and pseudoephedrine. Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID), helps reduce pain and inflammation. It usually begins to relieve pain within 20 to 30 minutes after taking it. Pseudoephedrine, which is a decongestant, works by narrowing the blood vessels in the nasal passages to reduce swelling and congestion. It generally starts to work within 30 minutes. Both medicines are absorbed quickly into the bloodstream, which is why they start working relatively fast. However, the exact time can vary depending on individual factors like metabolism and whether the medicine is taken with food. Together, they provide relief from symptoms like headache, fever, and nasal congestion.
Warnings and Precautions
Are there harms and risks from taking combination of Domperidone and Paracetamol?
Domperidone, which is used to relieve nausea and vomiting, can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Paracetamol, which is used to relieve pain and reduce fever, is generally well-tolerated but can cause side effects like nausea and rash. A significant adverse effect of paracetamol is liver damage, which refers to harm to the liver cells, especially when taken in high doses. Both medicines can cause nausea as a side effect. However, they have unique attributes: Domperidone is more likely to affect the heart, while paracetamol can impact the liver. It's important to use these medications as directed to minimize risks. Always consult a healthcare professional if you experience any severe side effects or have concerns about these medications.
Can I take combination of Domperidone and Paracetamol with other prescription drugs?
Domperidone, which is used to relieve nausea and vomiting, can interact with certain medications that affect heart rhythm, such as some antibiotics and antifungals. It is important to avoid these combinations as they can increase the risk of serious heart problems. Paracetamol, which is used to relieve pain and reduce fever, is generally safe but can interact with alcohol and certain medications that affect the liver, increasing the risk of liver damage. Both Domperidone and Paracetamol are metabolized in the liver, which means they are broken down by the liver. This shared attribute means that taking them together with other drugs that also affect the liver can increase the risk of liver-related side effects. It is important to consult a healthcare provider before combining these medications with others to ensure safety and avoid harmful interactions.
Can I take combination of Domperidone and Paracetamol if I am pregnant?
Domperidone, which is used to relieve nausea and vomiting, is not generally recommended during pregnancy. This is because there is limited information on its safety for pregnant women. It is important to consult a healthcare provider before using it. Paracetamol, which is used to relieve pain and reduce fever, is considered safe to use during pregnancy when taken at the recommended doses. It is often the first choice for pain relief in pregnant women. Both Domperidone and Paracetamol are used to manage symptoms, but they work differently. Domperidone targets nausea, while Paracetamol addresses pain and fever. A common attribute is that both should be used under medical advice during pregnancy to ensure safety for both the mother and the baby.
Can I take combination of Domperidone and Paracetamol while breastfeeding?
Domperidone, which is used to relieve nausea and vomiting, is generally considered safe during breastfeeding. It passes into breast milk in small amounts, but it is unlikely to harm a nursing infant. However, it should be used under medical supervision, especially if the mother or baby has any health issues. Paracetamol, which is used to relieve pain and reduce fever, is also considered safe for breastfeeding mothers. It passes into breast milk in very small amounts and is unlikely to affect the baby when used at recommended doses. Both Domperidone and Paracetamol share the common attribute of being generally safe for use during breastfeeding. They both pass into breast milk in small amounts and are unlikely to harm the infant. However, it is important for breastfeeding mothers to consult with healthcare providers before using these medications to ensure safety for both mother and child.
Who should avoid taking combination of Domperidone and Paracetamol?
When using Domperidone, which is a medication that helps relieve nausea and vomiting, it's important to be aware that it can cause heart problems, especially in people over 60 or those taking more than 30 mg per day. It should not be used by people with heart conditions or those taking certain other medications that affect the heart. Paracetamol, which is a pain reliever and fever reducer, can cause liver damage if taken in high doses or for a long time. People with liver disease or those who consume large amounts of alcohol should be cautious. Both Domperidone and Paracetamol should be used with caution in people with kidney problems. It's important to follow the recommended dosage and consult a healthcare provider if you have any underlying health conditions or are taking other medications.
