Domperidone
Nausea, Vomiting ... show more
.svg)
Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Dopamine-2 Receptor Antagonist
Controlled Drug Substance
NO
Domperidone
Summary
Domperidone is used to relieve nausea and vomiting, which are feelings of sickness and the act of throwing up. It also treats gastroparesis, which is a condition where the stomach takes too long to empty its contents.
Domperidone works by blocking dopamine receptors, which are parts of the body that respond to a chemical called dopamine, in the gut. This action helps speed up the movement of food through the stomach, reducing nausea and vomiting.
The usual starting dose for adults is 10 mg taken up to three times a day before meals. It is taken orally, which means by mouth, with water. The maximum recommended dose is 30 mg per day.
Common side effects include dry mouth, which is a lack of saliva, headache, and dizziness, which is a feeling of being unsteady or lightheaded. These effects are usually mild and may go away on their own.
Domperidone can cause heart-related side effects, especially in people with existing heart conditions. It is not recommended for those with a prolonged QT interval, which is a heart rhythm disorder. Always inform your doctor about your medical history before starting Domperidone.
Indications and Purpose
How does Domperidone work?
Domperidone works by blocking dopamine receptors in the gut, which helps speed up the movement of food through the stomach. This action reduces nausea and vomiting. Think of it like clearing a traffic jam in your stomach, allowing food to pass through more easily. Domperidone is effective for relieving symptoms of nausea and vomiting, making it helpful for conditions like gastroparesis.
Is Domperidone effective?
Domperidone is effective for relieving symptoms of nausea and vomiting. It works by blocking dopamine receptors in the gut, which helps speed up the movement of food through the stomach. Clinical studies support its effectiveness in improving these symptoms. If you have concerns about how well Domperidone is working for you, discuss them with your doctor. They can help assess your treatment and make any necessary adjustments.
What is Domperidone?
Domperidone is a medication used to relieve nausea and vomiting. It belongs to a class of drugs called dopamine antagonists, which work by blocking dopamine receptors in the gut. This action helps speed up the movement of food through the stomach. Domperidone is also used to treat symptoms of gastroparesis, which is a condition where the stomach takes too long to empty its contents. It may be used alone or with other therapies.
Directions for Use
For how long do I take Domperidone?
Domperidone is usually taken for short-term relief of symptoms like nausea and vomiting. The duration of use depends on your condition and how well you respond to the medication. Your doctor will provide specific instructions on how long to take Domperidone. Always follow your doctor's advice and talk with them before changing or stopping your treatment.
How do I dispose of Domperidone?
To dispose of Domperidone, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Domperidone?
Take Domperidone as prescribed by your doctor. It's usually taken before meals, up to three times a day. Swallow the tablets whole with water; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding food and beverage restrictions while on this medication.
How long does it take for Domperidone to start working?
Domperidone usually starts working within 30 to 60 minutes after taking it. You may notice relief from nausea and vomiting symptoms shortly after. The full therapeutic effect can vary depending on your condition and response to the medication. If you have concerns about how quickly Domperidone is working for you, discuss them with your doctor. They can help assess your treatment and make any necessary adjustments.
How should I store Domperidone?
Store Domperidone at room temperature, away from moisture and light. Keep it in its original packaging and out of reach of children. Do not store it in the bathroom, where humidity can affect the medication. Check the expiration date regularly and dispose of any unused or expired Domperidone properly. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Domperidone?
The usual starting dose of Domperidone for adults is 10 mg taken up to three times a day before meals. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 30 mg per day. Domperidone is not typically recommended for children or the elderly without specific medical advice. Always follow your doctor's dosing instructions for your personal health needs.
Warnings and Precautions
Can Domperidone be taken safely while breastfeeding?
Domperidone is sometimes used to increase milk supply, but its safety during breastfeeding is not fully established. It can pass into breast milk in small amounts. While adverse effects on the breastfed infant are not well-documented, it's important to discuss the risks and benefits with your doctor. They can help determine if Domperidone is appropriate for you while breastfeeding.
Can Domperidone be taken safely while pregnant?
The safety of Domperidone during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. Some studies suggest potential risks, so it's important to weigh the benefits and risks with your doctor. If you're pregnant or planning to become pregnant, discuss the safest treatment options for your condition with your healthcare provider.
Can I take Domperidone with other prescription drugs?
Domperidone can interact with certain medications, increasing the risk of heart rhythm problems. Avoid combining it with drugs that prolong the QT interval, such as some antibiotics and antifungals. Always inform your doctor about all medications you're taking to prevent interactions. They can help adjust your treatment plan to ensure safety and effectiveness.
Does Domperidone have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Domperidone include dry mouth, headache, and dizziness. These effects are usually mild. Serious side effects, like heart rhythm problems, are rare but require immediate medical attention. If you experience any new or worsening symptoms while taking Domperidone, contact your doctor. They can help determine if these symptoms are related to the medication and suggest appropriate actions.
Does Domperidone have any safety warnings?
Yes, Domperidone has safety warnings. It can cause heart-related side effects, especially in people with existing heart conditions. This medication may increase the risk of serious heart rhythm problems. It's important to follow your doctor's instructions and report any symptoms like dizziness or palpitations. Not adhering to these warnings can lead to severe consequences, including heart complications. Always discuss any concerns with your healthcare provider.
Is Domperidone addictive?
Domperidone is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Domperidone works by affecting the digestive system to help with nausea and vomiting. This mechanism does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Domperidone doesn't carry this risk.
Is Domperidone safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Domperidone, such as heart rhythm problems. It's important for older adults to use this medication under close medical supervision. Your doctor will consider your overall health and any existing conditions before prescribing Domperidone. Regular monitoring can help manage any potential risks.
Is it safe to drink alcohol while taking Domperidone?
It's best to avoid alcohol while taking Domperidone. Alcohol can increase the risk of side effects like dizziness and may worsen nausea. If you choose to drink, do so in moderation and be aware of how your body responds. Talk with your doctor about alcohol use while taking Domperidone to get personalized advice based on your health situation.
Is it safe to exercise while taking Domperidone?
Yes, it's generally safe to exercise while taking Domperidone. However, if you experience side effects like dizziness or fatigue, you might need to adjust your activity level. Listen to your body and avoid strenuous activities if you feel unwell. Stay hydrated and take breaks as needed. If you have concerns about exercising while on Domperidone, discuss them with your doctor.
Is it safe to stop Domperidone?
Domperidone is usually taken for short-term relief of symptoms like nausea. Stopping it suddenly is generally safe, but you should follow your doctor's advice. If you stop Domperidone before your symptoms are fully managed, they might return. Always talk with your doctor before stopping any medication to ensure it's safe and appropriate for your situation.
What are the most common side effects of Domperidone?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Domperidone include dry mouth, headache, and dizziness. These effects are usually mild and may go away on their own. If you notice new symptoms after starting Domperidone, they might be temporary or unrelated to the medication. Talk with your doctor if you have concerns about side effects. They can help determine if any symptoms are related to Domperidone.
Who should avoid taking Domperidone?
Domperidone should not be used if you have a known allergy to it or its ingredients. It's also contraindicated in people with certain heart conditions, such as prolonged QT interval, which is a heart rhythm disorder. Caution is needed if you have liver or kidney problems. Always inform your doctor about your medical history before starting Domperidone to ensure it's safe for you.
Forms / Brands
