Diclofenac + Paracetamol
Find more information about this combination medication at the webpages for diclofenac and diclofenac diclofenac and paracetamol and
Juvenile Arthritis, Rheumatoid Arthritis ... show more
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Advisory
- This medicine contains a combination of 2 drugs diclofenac and paracetamol.
- diclofenac and paracetamol are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
NO
diclofenac + paracetamol
Summary
Diclofenac is used for conditions involving pain and inflammation like arthritis, menstrual pain, and acute injuries. Paracetamol is used for mild to moderate pain relief and fever reduction, suitable for headaches, muscle aches, and cold symptoms. Both are often used together to manage pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis.
Diclofenac works by inhibiting enzymes that produce inflammatory chemicals in the body, reducing inflammation and pain. Paracetamol reduces pain and fever by blocking pain signals in the brain. Both are absorbed quickly into the bloodstream, providing relief relatively quickly.
The usual adult daily dose for Diclofenac is typically 75 to 150 mg divided into two or three doses. For Paracetamol, the usual dose is 500 mg to 1000 mg every 4 to 6 hours, not exceeding 4000 mg in a 24-hour period.
Common side effects of Diclofenac include stomach upset, nausea, and headache. More serious risks include gastrointestinal bleeding and cardiovascular events. Paracetamol is generally well-tolerated, but overdose can lead to severe liver damage. Both medications can cause allergic reactions, though this is rare.
Diclofenac should be used with caution in individuals with a history of gastrointestinal bleeding, cardiovascular disease, or kidney impairment. It is contraindicated in those with known hypersensitivity to NSAIDs. Paracetamol should be used cautiously in individuals with liver disease or those who consume large amounts of alcohol.
Indications and Purpose
How does combination of Diclofenac and Paracetamol work?
Diclofenac works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins that cause inflammation and pain. This makes it effective for reducing inflammation and pain in conditions like arthritis. Paracetamol, on the other hand, acts centrally in the brain to reduce pain and fever, though its exact mechanism is not fully understood. Both medications provide pain relief, but Diclofenac also addresses inflammation, making them complementary in managing various types of pain.
How effective is combination of Diclofenac and Paracetamol?
Diclofenac's effectiveness is supported by clinical trials demonstrating its ability to reduce inflammation and pain in conditions like arthritis and acute injuries. Paracetamol is widely used and proven effective for pain relief and fever reduction, with a well-established safety profile when used as directed. Both medications are commonly prescribed and have been shown to provide significant symptom relief in various studies. Their combined use can offer a broader spectrum of pain management, addressing both inflammation and general pain.
Directions for Use
What is the usual dose of combination of Diclofenac and Paracetamol?
For Diclofenac, the usual adult dose is 75 to 150 mg per day, divided into two or three doses. For Paracetamol, the typical adult dose is 500 mg to 1000 mg every 4 to 6 hours, not exceeding 4000 mg per day. Both medications should be taken as directed by a healthcare provider to avoid potential side effects. Diclofenac is particularly effective for inflammatory pain, while Paracetamol is commonly used for general pain relief and fever reduction. It's important to adhere to the recommended dosages to prevent liver damage from Paracetamol and gastrointestinal issues from Diclofenac.
How does one take combination of Diclofenac and Paracetamol?
Diclofenac should be taken with food or milk to minimize gastrointestinal discomfort, while Paracetamol can be taken with or without food. It's important to follow the prescribed dosage and not exceed the recommended daily limits for either medication. Patients should avoid alcohol while taking Paracetamol to prevent liver damage. For Diclofenac, it's advisable to avoid other NSAIDs to reduce the risk of gastrointestinal bleeding. Both medications should be used as directed by a healthcare provider to ensure safety and effectiveness.
For how long is combination of Diclofenac and Paracetamol taken?
Diclofenac and Paracetamol are typically used for short-term relief of pain and inflammation. Diclofenac is often prescribed for acute conditions and should not be used for extended periods due to potential cardiovascular and gastrointestinal risks. Paracetamol can be used for longer durations but should not exceed the recommended daily dose to avoid liver damage. Both medications are effective for managing pain, but long-term use should be monitored by a healthcare provider to prevent adverse effects.
How long does it take for combination of Diclofenac and Paracetamol to work?
Diclofenac and Paracetamol both work to relieve pain, but they have different onset times. Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), typically begins to relieve pain within 30 minutes to an hour after ingestion. Paracetamol, also known as acetaminophen, usually starts working within 30 minutes. Both medications are used to treat mild to moderate pain, but Diclofenac also reduces inflammation, which Paracetamol does not. The combination of these two can provide a more comprehensive approach to pain management, addressing both pain and inflammation.
Warnings and Precautions
Are there harms and risks from taking combination of Diclofenac and Paracetamol?
Common side effects of Diclofenac include gastrointestinal issues such as stomach pain, nausea, and diarrhea. It can also cause more serious effects like ulcers and increased risk of heart attack or stroke with long-term use. Paracetamol is generally well-tolerated, but overdose can lead to severe liver damage. Both medications can cause allergic reactions, though this is rare. It's important to use these medications as directed to minimize risks and consult a healthcare provider if any severe side effects occur.
Can I take combination of Diclofenac and Paracetamol with other prescription drugs?
Diclofenac can interact with anticoagulants like warfarin, increasing the risk of bleeding. It may also interact with other NSAIDs, increasing the risk of gastrointestinal issues. Paracetamol can interact with warfarin, potentially enhancing its anticoagulant effect. Both medications should be used cautiously with other drugs that affect liver function. It's important to inform your healthcare provider of all medications you are taking to avoid potential interactions and ensure safe use of Diclofenac and Paracetamol.
Can I take combination of Diclofenac and Paracetamol if I am pregnant?
Paracetamol is generally considered safe for use during pregnancy when used as directed, as it does not pose significant risks to the fetus. Diclofenac, however, should be avoided, especially in the third trimester, due to potential risks such as premature closure of the fetal ductus arteriosus. Pregnant women should consult their healthcare provider before using these medications to ensure safety and to discuss any potential risks and benefits.
Can I take combination of Diclofenac and Paracetamol while breastfeeding?
Paracetamol is generally considered safe for use during breastfeeding, as it is excreted in breast milk in small amounts and is unlikely to harm the infant. Diclofenac, however, should be used with caution during lactation, as its safety profile is less established. It's important for breastfeeding mothers to consult with a healthcare provider before using these medications to ensure the safety of the infant and to discuss any potential risks and benefits.
Who should avoid taking combination of Diclofenac and Paracetamol?
Diclofenac is contraindicated in individuals with a history of heart disease, gastrointestinal bleeding, or ulcers. It should be used with caution in patients with kidney or liver impairment. Paracetamol should not be used in excess of the recommended dose due to the risk of severe liver damage. Both medications should be avoided in individuals with known allergies to their components. It's crucial to follow dosing instructions and consult a healthcare provider if there are any concerns or pre-existing conditions.
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