Diclofenac
Juvenile Arthritis, Rheumatoid Arthritis ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
NO
Diclofenac
Summary
Diclofenac is used to relieve pain and inflammation associated with conditions like arthritis, migraines, and menstrual pain. It's also used in treating osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders.
Diclofenac works by inhibiting the enzymes COX1 and COX2, which are involved in the production of prostaglandins, substances that cause inflammation and pain. By reducing their production, it helps alleviate these symptoms.
For adults, the usual daily dose of Diclofenac ranges from 75 mg to 150 mg, divided into two or three doses. For children aged 1-12 years with juvenile chronic arthritis, the dose is 1-3 mg/kg per day in divided doses.
Common side effects of Diclofenac include gastrointestinal issues like nausea and diarrhea, dizziness, and headaches. Serious adverse effects can include cardiovascular events and gastrointestinal bleeding.
Diclofenac carries risks of serious cardiovascular events, gastrointestinal bleeding, and liver damage. It's not recommended for patients with certain heart conditions, active ulcers, or known hypersensitivity to NSAIDs. It is also not recommended during pregnancy, especially after 20 weeks, and while breastfeeding.
Indications and Purpose
How does Diclofenac work?
Diclofenac works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are substances that mediate inflammation and pain, so reducing their production helps alleviate these symptoms.
How does one know if Diclofenac is working?
The benefit of Diclofenac is evaluated by monitoring the reduction in pain and inflammation symptoms. Regular follow-ups with your doctor can help assess its effectiveness and adjust the dosage if necessary.
Is Diclofenac effective?
Diclofenac is proven effective in relieving pain and inflammation associated with conditions like arthritis, migraines, and menstrual pain. It works by inhibiting the production of substances in the body that cause inflammation and pain.
What is Diclofenac?
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like arthritis, migraines, and menstrual pain. It works by inhibiting the production of substances in the body that cause inflammation and pain.
What is Diclofenac used for?
Diclofenac is indicated for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and migraines. It is also used for treating painful menstrual periods.
Directions for Use
For how long do I take Diclofenac?
Diclofenac is typically used for the shortest duration necessary to control symptoms, often for a few days to a couple of weeks. Long-term use should be under strict medical supervision due to potential side effects.
How do I dispose of Diclofenac?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Diclofenac?
Diclofenac can be taken with or without food, but taking it with food may help reduce stomach upset. There are no specific food restrictions, but avoid alcohol to reduce the risk of stomach bleeding.
How long does it take for Diclofenac to start working?
Diclofenac typically starts working within 30 minutes to an hour after taking it, providing relief from pain and inflammation.
How should I store Diclofenac?
Store Diclofenac in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and pets to prevent accidental ingestion.
What is the usual dose of Diclofenac?
For adults, the usual daily dose of Diclofenac ranges from 75 mg to 150 mg, divided into two or three doses. For children aged 1-12 years with juvenile chronic arthritis, the dose is 1-3 mg/kg per day in divided doses. Always follow your doctor's advice for the correct dosage.
Warnings and Precautions
Can Diclofenac be taken safely while breastfeeding?
Diclofenac passes into breast milk in small amounts. While short-term use is generally considered safe, consult your doctor to weigh the benefits and risks before using Diclofenac while breastfeeding.
Can Diclofenac be taken safely while pregnant?
Diclofenac is not recommended during pregnancy, especially after 20 weeks, due to risks of fetal harm such as kidney dysfunction and premature closure of the ductus arteriosus. Consult your doctor for safer alternatives.
Can I take Diclofenac with other prescription drugs?
Diclofenac can interact with anticoagulants, other NSAIDs, SSRIs, and certain blood pressure medications, increasing the risk of bleeding or affecting kidney function. Always inform your doctor about all medications you are taking.
Can I take Diclofenac with vitamins or supplements?
There are no well-documented interactions between Diclofenac and vitamins or supplements. However, it's important to inform your healthcare provider about all medications and supplements you're taking. This helps prevent potential interactions and ensures safe use. If you have concerns about specific supplements, consult your healthcare provider for personalized advice.
Does Diclofenac have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. Diclofenac can cause stomach pain, nausea, or headaches, which are common. Rare but serious adverse effects include heart attack, stroke, or severe allergic reactions. If you experience chest pain, difficulty breathing, or swelling of the face or throat, seek medical help immediately. Always report new symptoms to your healthcare provider and consult them before stopping the medication.
Does Diclofenac have any safety warnings?
Diclofenac has safety warnings, including risks of heart attack or stroke, especially with long-term use or high doses. It can also cause stomach bleeding or ulcers. Symptoms to watch for include chest pain, shortness of breath, weakness, slurred speech, or black stools. If you experience any of these, seek medical help immediately. It's important to use the lowest effective dose for the shortest time possible and to consult your doctor if you have concerns.
Is Diclofenac addictive?
Diclofenac is not known to be addictive or habit-forming. It does not have the potential to cause physical or psychological dependence. Therefore, there are no specific behaviors or warning signs related to addiction for this medicine. It's important to use Diclofenac as prescribed by your doctor and to discuss any concerns you may have about its use.
Is Diclofenac safe for the elderly?
Elderly patients are at greater risk for serious side effects from Diclofenac, such as gastrointestinal bleeding and cardiovascular events. It's recommended to use the lowest effective dose for the shortest duration possible and to monitor for adverse effects.
Is it safe to drink alcohol while taking Diclofenac?
Drinking alcohol while taking Diclofenac can increase the risk of stomach bleeding. It's advisable to limit alcohol consumption to reduce this risk. Always consult your doctor for personalized advice.
Is it safe to exercise while taking Diclofenac?
Diclofenac does not inherently limit the ability to exercise. However, if you experience side effects like dizziness or fatigue, it may be wise to avoid strenuous activities until you feel better. Consult your doctor for personalized advice.
Is it safe to stop Diclofenac?
Diclofenac is often used for symptomatic relief of pain or inflammation, not for chronic conditions. Stopping it suddenly usually doesn't cause withdrawal symptoms, but your pain or inflammation might return. There are no life-threatening risks from stopping Diclofenac abruptly. However, it's always best to consult your doctor before stopping any medication to ensure it's safe and to discuss alternative treatments if needed.
What are the most common side effects of Diclofenac?
A side effect is an unwanted reaction to a medicine. Common side effects of Diclofenac include stomach pain, nausea, headache, dizziness, and rash. These effects are usually mild and may go away as your body adjusts. It's important to remember that new symptoms might not be related to the medicine. Always talk to your healthcare provider before stopping Diclofenac to ensure it's safe and to discuss any concerns.
Who should avoid taking Diclofenac?
Diclofenac carries risks of serious cardiovascular events, gastrointestinal bleeding, and liver damage. It's contraindicated in patients with certain heart conditions, active ulcers, or known hypersensitivity to NSAIDs. Always consult your doctor before use.
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