Diclofenac
Juvenile Arthritis, Rheumatoid Arthritis ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
NO
Diclofenac
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Click HereSummary
Diclofenac is used to relieve pain and inflammation associated with conditions like arthritis, migraines, and menstrual pain. It's also used in treating osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders.
Diclofenac works by inhibiting the enzymes COX1 and COX2, which are involved in the production of prostaglandins, substances that cause inflammation and pain. By reducing their production, it helps alleviate these symptoms.
For adults, the usual daily dose of Diclofenac ranges from 75 mg to 150 mg, divided into two or three doses. For children aged 1-12 years with juvenile chronic arthritis, the dose is 1-3 mg/kg per day in divided doses.
Common side effects of Diclofenac include gastrointestinal issues like nausea and diarrhea, dizziness, and headaches. Serious adverse effects can include cardiovascular events and gastrointestinal bleeding.
Diclofenac carries risks of serious cardiovascular events, gastrointestinal bleeding, and liver damage. It's not recommended for patients with certain heart conditions, active ulcers, or known hypersensitivity to NSAIDs. It is also not recommended during pregnancy, especially after 20 weeks, and while breastfeeding.
Indications and Purpose
What is Diclofenac used for?
Diclofenac is indicated for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal disorders, and migraines. It is also used for treating painful menstrual periods.
How does Diclofenac work?
Diclofenac works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are substances that mediate inflammation and pain, so reducing their production helps alleviate these symptoms.
Is Diclofenac effective?
Diclofenac is proven effective in relieving pain and inflammation associated with conditions like arthritis, migraines, and menstrual pain. It works by inhibiting the production of substances in the body that cause inflammation and pain.
How does one know if Diclofenac is working?
The benefit of Diclofenac is evaluated by monitoring the reduction in pain and inflammation symptoms. Regular follow-ups with your doctor can help assess its effectiveness and adjust the dosage if necessary.
Directions for Use
What is the usual dose of Diclofenac?
For adults, the usual daily dose of Diclofenac ranges from 75 mg to 150 mg, divided into two or three doses. For children aged 1-12 years with juvenile chronic arthritis, the dose is 1-3 mg/kg per day in divided doses. Always follow your doctor's advice for the correct dosage.
How do I take Diclofenac?
Diclofenac can be taken with or without food, but taking it with food may help reduce stomach upset. There are no specific food restrictions, but avoid alcohol to reduce the risk of stomach bleeding.
For how long do I take Diclofenac?
Diclofenac is typically used for the shortest duration necessary to control symptoms, often for a few days to a couple of weeks. Long-term use should be under strict medical supervision due to potential side effects.
How long does it take for Diclofenac to start working?
Diclofenac typically starts working within 30 minutes to an hour after taking it, providing relief from pain and inflammation.
How should I store Diclofenac?
Store Diclofenac in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and pets to prevent accidental ingestion.
Warnings and Precautions
Who should avoid taking Diclofenac?
Diclofenac carries risks of serious cardiovascular events, gastrointestinal bleeding, and liver damage. It's contraindicated in patients with certain heart conditions, active ulcers, or known hypersensitivity to NSAIDs. Always consult your doctor before use.
Can I take Diclofenac with other prescription drugs?
Diclofenac can interact with anticoagulants, other NSAIDs, SSRIs, and certain blood pressure medications, increasing the risk of bleeding or affecting kidney function. Always inform your doctor about all medications you are taking.
Can I take Diclofenac with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Diclofenac be taken safely while pregnant?
Diclofenac is not recommended during pregnancy, especially after 20 weeks, due to risks of fetal harm such as kidney dysfunction and premature closure of the ductus arteriosus. Consult your doctor for safer alternatives.
Can Diclofenac be taken safely while breastfeeding?
Diclofenac passes into breast milk in small amounts. While short-term use is generally considered safe, consult your doctor to weigh the benefits and risks before using Diclofenac while breastfeeding.
Is Diclofenac safe for the elderly?
Elderly patients are at greater risk for serious side effects from Diclofenac, such as gastrointestinal bleeding and cardiovascular events. It's recommended to use the lowest effective dose for the shortest duration possible and to monitor for adverse effects.
Is it safe to exercise while taking Diclofenac?
Diclofenac does not inherently limit the ability to exercise. However, if you experience side effects like dizziness or fatigue, it may be wise to avoid strenuous activities until you feel better. Consult your doctor for personalized advice.
Is it safe to drink alcohol while taking Diclofenac?
Drinking alcohol while taking Diclofenac can increase the risk of stomach bleeding. It's advisable to limit alcohol consumption to reduce this risk. Always consult your doctor for personalized advice.
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