Amlodipine + Metoprolol Succinate

Find more information about this combination medication at the webpages for metoprolol succinate and amlodipine

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Brand Name

Angicam-M Tablet ER , Metlio AM 5 mg/50 mg Tablet ... show more

Approved Treatment Indication:

Hypertension, Variant Angina Pectoris ... show more

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This medicine contains a combination of 2 drugs amlodipine and metoprolol succinate.
amlodipine and metoprolol succinate are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions are Amlodipine and Metoprolol succinate used for?
Amlodipine is used to treat high blood pressure, which is a condition where the force of the blood against the artery walls is too high, and angina, which is chest pain due to reduced blood flow to the heart. Metoprolol succinate is used for high blood pressure, angina, heart failure, which is when the heart can't pump blood effectively, and to improve survival after a heart attack. Both medications help reduce the risk of cardiovascular events like heart attacks and strokes.
How do Amlodipine and Metoprolol succinate work in the body?
Amlodipine works as a calcium channel blocker, which means it relaxes and widens blood vessels by blocking calcium from entering the cells of the heart and blood vessel walls. This helps lower blood pressure and reduce the heart's workload. Metoprolol succinate is a beta-blocker, which slows the heart rate and reduces the force of heart contractions, helping to lower blood pressure and decrease the heart's oxygen demand. Both medications improve blood flow and reduce the risk of cardiovascular events, but they achieve these effects through different mechanisms.
What are the usual dosages and routes of administration for Amlodipine and Metoprolol succinate?
Amlodipine is usually started at 5 mg once daily, which can be increased to a maximum of 10 mg daily based on the patient's response. Metoprolol succinate is typically started at 25 mg to 100 mg once daily, with adjustments based on blood pressure response and tolerance, up to a maximum of 400 mg per day. Both medications are taken orally, meaning by mouth, and dosages are often adjusted based on individual patient needs and responses.
What are the most commonly observed adverse effects of Amlodipine and Metoprolol succinate?
Common side effects of Amlodipine include swelling of the hands, feet, ankles, or lower legs, dizziness, and flushing, which is a sudden reddening of the face. Metoprolol succinate may cause dizziness, tiredness, depression, and gastrointestinal issues like nausea and diarrhea. Both medications can cause dizziness and fatigue, which are common to many blood pressure-lowering drugs. Serious adverse effects, though rare, include severe bradycardia, which is a very slow heart rate, hypotension, which is low blood pressure, and worsening heart failure for Metoprolol succinate.
What are the important safety warnings and contraindications for Amlodipine and Metoprolol succinate?
Amlodipine should be used cautiously in patients with severe aortic stenosis, which is a narrowing of the heart's aortic valve, or heart failure, as it can worsen these conditions. Metoprolol succinate is contraindicated in patients with severe bradycardia, heart block, which is a problem with the heart's electrical system, or cardiogenic shock, which is a condition where the heart suddenly can't pump enough blood. Both medications should not be stopped abruptly, as this can lead to worsening angina or heart attack. Patients with liver impairment should use these medications with caution, and regular monitoring is advised.

Government Approvals

None

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Beta-Adrenergic Blocker and Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker

Controlled Drug Substance

Summary

What conditions are Amlodipine and Metoprolol succinate used for?
Amlodipine is used to treat high blood pressure, which is a condition where the force of the blood against the artery walls is too high, and angina, which is chest pain due to reduced blood flow to the heart. Metoprolol succinate is used for high blood pressure, angina, heart failure, which is when the heart can't pump blood effectively, and to improve survival after a heart attack. Both medications help reduce the risk of cardiovascular events like heart attacks and strokes.
How do Amlodipine and Metoprolol succinate work in the body?
Amlodipine works as a calcium channel blocker, which means it relaxes and widens blood vessels by blocking calcium from entering the cells of the heart and blood vessel walls. This helps lower blood pressure and reduce the heart's workload. Metoprolol succinate is a beta-blocker, which slows the heart rate and reduces the force of heart contractions, helping to lower blood pressure and decrease the heart's oxygen demand. Both medications improve blood flow and reduce the risk of cardiovascular events, but they achieve these effects through different mechanisms.
What are the usual dosages and routes of administration for Amlodipine and Metoprolol succinate?
Amlodipine is usually started at 5 mg once daily, which can be increased to a maximum of 10 mg daily based on the patient's response. Metoprolol succinate is typically started at 25 mg to 100 mg once daily, with adjustments based on blood pressure response and tolerance, up to a maximum of 400 mg per day. Both medications are taken orally, meaning by mouth, and dosages are often adjusted based on individual patient needs and responses.
What are the most commonly observed adverse effects of Amlodipine and Metoprolol succinate?
Common side effects of Amlodipine include swelling of the hands, feet, ankles, or lower legs, dizziness, and flushing, which is a sudden reddening of the face. Metoprolol succinate may cause dizziness, tiredness, depression, and gastrointestinal issues like nausea and diarrhea. Both medications can cause dizziness and fatigue, which are common to many blood pressure-lowering drugs. Serious adverse effects, though rare, include severe bradycardia, which is a very slow heart rate, hypotension, which is low blood pressure, and worsening heart failure for Metoprolol succinate.
What are the important safety warnings and contraindications for Amlodipine and Metoprolol succinate?
Amlodipine should be used cautiously in patients with severe aortic stenosis, which is a narrowing of the heart's aortic valve, or heart failure, as it can worsen these conditions. Metoprolol succinate is contraindicated in patients with severe bradycardia, heart block, which is a problem with the heart's electrical system, or cardiogenic shock, which is a condition where the heart suddenly can't pump enough blood. Both medications should not be stopped abruptly, as this can lead to worsening angina or heart attack. Patients with liver impairment should use these medications with caution, and regular monitoring is advised.

Indications and Purpose

How does combination of Amlodipine and Metoprolol succinate work?

Amlodipine works by blocking calcium channels in the blood vessels, leading to relaxation and dilation of the vessels, which lowers blood pressure and reduces the heart's workload. Metoprolol succinate acts as a beta-blocker, slowing the heart rate and reducing the force of heart contractions, which also helps lower blood pressure and decrease the heart's oxygen demand. Both medications aim to improve blood flow and reduce the risk of cardiovascular events, but they achieve these effects through different mechanisms in the body.

How effective is combination of Amlodipine and Metoprolol succinate?

Clinical trials and studies have demonstrated the effectiveness of Amlodipine in reducing blood pressure and managing angina by improving blood flow through vasodilation. Metoprolol succinate has been shown to effectively lower blood pressure, reduce heart rate, and improve survival rates in heart failure patients. Both medications have been proven to reduce the risk of cardiovascular events such as heart attacks and strokes. Their effectiveness is supported by their widespread use in clinical practice and their inclusion in treatment guidelines for hypertension and cardiovascular disease management.

Directions for Use

What is the usual dose of combination of Amlodipine and Metoprolol succinate?

For Amlodipine, the usual adult starting dose is 5 mg once daily, which can be increased to a maximum of 10 mg daily depending on the patient's response. Metoprolol succinate is typically started at 25 mg to 100 mg once daily, with the dose adjusted based on the patient's blood pressure response and tolerance, up to a maximum of 400 mg per day. Both medications are taken orally and are often adjusted based on individual patient needs and responses. They are both used to manage high blood pressure and other cardiovascular conditions.

How does one take combination of Amlodipine and Metoprolol succinate?

Amlodipine can be taken with or without food, and it is important to take it at the same time each day to maintain consistent blood levels. Metoprolol succinate should be taken with or immediately after meals to enhance absorption and reduce the risk of side effects. Patients should avoid alcohol while taking Metoprolol succinate, as it can increase the risk of side effects. Both medications require adherence to prescribed dosages and regular monitoring by a healthcare provider to ensure effectiveness and safety.

For how long is combination of Amlodipine and Metoprolol succinate taken?

Amlodipine and Metoprolol succinate are typically used as long-term treatments for managing high blood pressure and other cardiovascular conditions. Both medications are intended for continuous use to maintain their therapeutic effects, and they do not cure the underlying conditions but help manage symptoms and reduce risks. Patients are advised to continue taking these medications even if they feel well, as stopping them abruptly can lead to adverse effects. Regular monitoring by a healthcare provider is essential to ensure the medications are working effectively and to adjust dosages as needed.

How long does it take for combination of Amlodipine and Metoprolol succinate to work?

Amlodipine and Metoprolol succinate both work to lower blood pressure, but they do so in different ways. Amlodipine, a calcium channel blocker, typically begins to work within a few hours, with its full effect on blood pressure seen after several days of consistent use. Metoprolol succinate, a beta-blocker, also starts to work within a few hours, but its full effect on blood pressure and heart rate may take a week or more to become apparent. Both medications require regular dosing to maintain their effects, and neither provides immediate relief for acute symptoms.

Warnings and Precautions

Are there harms and risks from taking combination of Amlodipine and Metoprolol succinate?

Common side effects of Amlodipine include swelling of the hands, feet, ankles, or lower legs, dizziness, and flushing. Metoprolol succinate may cause dizziness, tiredness, depression, and gastrointestinal issues like nausea and diarrhea. Both medications can cause dizziness and fatigue, which are common to many blood pressure-lowering drugs. Serious adverse effects, though rare, include severe bradycardia, hypotension, and worsening heart failure for Metoprolol succinate, and more severe chest pain or heart attack for Amlodipine. Patients should report any severe or persistent side effects to their healthcare provider.

Can I take combination of Amlodipine and Metoprolol succinate with other prescription drugs?

Amlodipine can interact with other antihypertensive drugs, increasing the risk of hypotension. It may also interact with CYP3A inhibitors, which can increase its concentration in the blood. Metoprolol succinate can interact with other beta-blockers, calcium channel blockers, and drugs that affect heart rate, potentially leading to bradycardia or heart block. Both medications can interact with drugs that affect liver enzymes, altering their metabolism and effectiveness. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.

Can I take combination of Amlodipine and Metoprolol succinate if I am pregnant?

Amlodipine's safety during pregnancy is not well established, and it should only be used if the benefits outweigh the risks. Metoprolol succinate has not shown a significant risk of major birth defects, but there are reports of intrauterine growth restriction and preterm birth. Both medications should be used during pregnancy only if clearly needed, and under the guidance of a healthcare provider. Pregnant women should be closely monitored to manage any potential risks to the mother and fetus.

Can I take combination of Amlodipine and Metoprolol succinate while breastfeeding?

Amlodipine is present in human milk, but no adverse effects on breastfed infants have been observed. Metoprolol is also excreted in breast milk, with the relative infant dose being low. While both medications are generally considered safe during breastfeeding, monitoring the infant for any adverse effects such as bradycardia or hypotension is recommended. Mothers should discuss with their healthcare provider the risks and benefits of continuing these medications while breastfeeding to ensure the safety of the infant.

Who should avoid taking combination of Amlodipine and Metoprolol succinate?

Amlodipine should be used cautiously in patients with severe aortic stenosis or heart failure, as it can worsen these conditions. Metoprolol succinate is contraindicated in patients with severe bradycardia, heart block, or cardiogenic shock. Both medications should not be stopped abruptly, as this can lead to worsening angina or heart attack. Patients with liver impairment should use these medications with caution, and regular monitoring is advised. It's crucial for patients to inform their healthcare provider of their full medical history to avoid potential complications.