Metoprolol succinate
Hypertension, Angina Pectoris ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Beta-Adrenergic Blocker
Controlled Drug Substance
NO
Metoprolol succinate
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Click HereSummary
Metoprolol succinate is used to treat high blood pressure, chest pain (angina), and heart failure. It can also help prevent heart attacks.
Metoprolol succinate is a beta-blocker. It works by blocking certain signals in the heart, which slows the heart rate and reduces the heart's workload, thereby lowering blood pressure and preventing chest pain.
The dosage of Metoprolol succinate depends on the condition being treated. For high blood pressure, the starting dose is usually 25-100 mg once daily, with a maximum of 400 mg/day. For angina, it's 100-400 mg once daily. For heart failure, you start with 12.5-25 mg once daily and gradually increase to a target dose of 200 mg/day as tolerated. The medicine is taken orally, ideally with food.
Common side effects of Metoprolol succinate include tiredness, dizziness, depression, diarrhea, shortness of breath, slow heartbeat, and rash. More serious but less common side effects include worsening chest pain, heart attack, or heart failure.
Do not stop taking Metoprolol succinate suddenly without talking to your doctor, as this can cause serious heart problems. Avoid driving or operating machinery until you know how the medicine affects you. Also, avoid alcohol as it can increase the risk of side effects. If you have heart failure, tell your doctor if you gain weight or have shortness of breath.
Indications and Purpose
What is Metoprolol succinate used for?
Metoprolol succinate is indicated for the treatment of high blood pressure, angina pectoris, and heart failure. It is also used to improve survival after a heart attack and may be prescribed for certain types of irregular heartbeats. Always consult your doctor for specific indications and treatment plans.
How does Metoprolol succinate work?
Metoprolol succinate works by blocking beta-adrenergic receptors in the heart, which reduces the effects of adrenaline. This leads to a slower heart rate and decreased force of heart contractions, resulting in lower blood pressure and improved blood flow. It also helps reduce the heart's oxygen demand, alleviating angina symptoms.
Is Metoprolol succinate effective?
Metoprolol succinate has been shown in clinical trials to effectively lower blood pressure, reduce angina attacks, and improve survival rates after heart attacks. It works by relaxing blood vessels and slowing the heart rate, which improves blood flow and decreases blood pressure. These benefits have been consistently observed in various studies.
How does one know if Metoprolol succinate is working?
The benefit of Metoprolol succinate is evaluated by monitoring blood pressure, heart rate, and symptoms of angina or heart failure. Regular follow-up appointments with your doctor are important to assess the effectiveness and adjust the dosage if necessary. Self-monitoring of blood pressure at home can also be helpful.
Directions for Use
What is the usual dose of Metoprolol succinate?
For adults, the usual initial dose of Metoprolol succinate for hypertension is 25 mg to 100 mg once daily. For children aged 6 years and older, the starting dose is 1 mg/kg once daily, not exceeding 50 mg initially. Dosage adjustments are made based on the patient's response and can be increased gradually. Always follow your doctor's specific instructions.
How do I take Metoprolol succinate?
Metoprolol succinate should be taken with or immediately after meals to enhance absorption. There are no specific food restrictions, but it's important to maintain a healthy diet low in fat and salt to support blood pressure management. Always follow your doctor's instructions regarding dosage and administration.
For how long do I take Metoprolol succinate?
Metoprolol succinate is typically used as a long-term treatment for conditions like hypertension, angina, and heart failure. The duration of use depends on the individual's condition and response to treatment. It's important to follow your doctor's guidance and not stop taking the medication without consulting them.
How long does it take for Metoprolol succinate to start working?
Metoprolol succinate begins to work within a few hours of taking the first dose, but it may take a week or more to see the full effect on blood pressure. For heart failure or angina, it may take longer to notice improvements. Consistent use as prescribed is important for optimal results.
How should I store Metoprolol succinate?
Store Metoprolol succinate in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. For disposal, use a medicine take-back program to prevent accidental ingestion by pets or children.
Warnings and Precautions
Who should avoid taking Metoprolol succinate?
Metoprolol succinate is contraindicated in patients with severe bradycardia, heart block, cardiogenic shock, and decompensated heart failure. Abrupt cessation can worsen angina or cause heart attacks. Patients with asthma, diabetes, or thyroid disorders should use it cautiously. Always consult a doctor before starting or stopping the medication.
Can I take Metoprolol succinate with other prescription drugs?
Metoprolol succinate can interact with catecholamine depleting drugs, CYP2D6 inhibitors, and other medications like digitalis, clonidine, and calcium channel blockers, increasing the risk of bradycardia and hypotension. Always inform your doctor about all medications and supplements you are taking to avoid potential interactions.
Can I take Metoprolol succinate with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Metoprolol succinate be taken safely while pregnant?
Metoprolol succinate should be used during pregnancy only if clearly needed, as untreated hypertension poses risks to both mother and fetus. Available data do not show a significant risk of major birth defects, but there are reports of intrauterine growth restriction. Always consult your doctor for personalized advice during pregnancy.
Can Metoprolol succinate be taken safely while breastfeeding?
Metoprolol succinate is present in breast milk, but the amount is generally low. No adverse effects on breastfed infants have been identified. However, monitor the infant for signs of beta-blockade, such as bradycardia. Consult your doctor for personalized advice if you are breastfeeding while taking this medication.
Is Metoprolol succinate safe for the elderly?
Elderly patients may be more sensitive to the effects of Metoprolol succinate, particularly its impact on heart rate and blood pressure. It's important to start with a lower dose and adjust gradually under medical supervision. Regular monitoring of heart function and blood pressure is recommended to ensure safe use.
Is it safe to exercise while taking Metoprolol succinate?
Metoprolol succinate can cause fatigue and dizziness, which may affect your ability to exercise. However, it is often prescribed to improve heart function, which can enhance exercise tolerance over time. If you experience significant limitations, consult your doctor for advice.
Is it safe to drink alcohol while taking Metoprolol succinate?
Drinking alcohol while taking Metoprolol succinate can increase the risk of side effects such as dizziness and drowsiness. Alcohol may also affect how the medication is released from extended-release formulations, potentially leading to increased side effects. It's advisable to avoid alcohol or consult your doctor for personalized advice.
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