Amlodipine + Losartan

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Approved Treatment Indication:

Hypertension, Left Ventricular Hypertrophy ... show more

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Advisory

This medicine contains a combination of 2 drugs Amlodipine and Losartan.
Amlodipine and Losartan are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions are Amlodipine and Losartan used for?
Amlodipine is used to treat high blood pressure, which is also known as hypertension, and certain types of chest pain called angina. Losartan is used for high blood pressure, reducing the risk of stroke in patients with a heart condition called left ventricular hypertrophy, and managing kidney disease in people with type 2 diabetes. Both medications help lower blood pressure and reduce the risk of heart-related complications.
How do Amlodipine and Losartan work in the body?
Amlodipine is a calcium channel blocker, which means it relaxes blood vessels by preventing calcium from entering the cells of the heart and blood vessel walls, leading to lower blood pressure. Losartan is an angiotensin II receptor blocker, which means it blocks a natural substance that narrows blood vessels, allowing blood to flow more easily and reducing blood pressure. Both medications help improve blood flow and reduce the risk of cardiovascular events like heart attacks and strokes.
What are the usual dosages and routes of administration for Amlodipine and Losartan?
Amlodipine is usually started at 5mg once daily, which can be increased to a maximum of 10mg daily based on the patient's response. Losartan is typically taken at 50mg to 100mg once a day for high blood pressure, with doses ranging from 12.5mg to 150mg for heart failure. Both medications are taken orally, meaning by mouth, and can be adjusted based on individual needs and response to treatment.
What are the most commonly observed adverse effects of Amlodipine and Losartan?
Common side effects of Amlodipine include swelling of the ankles, dizziness, and fatigue. For Losartan, side effects may include dizziness, upper respiratory infections, and back pain. Both medications can cause low blood pressure, known as hypotension, and should be used with caution in patients with certain medical conditions. Serious side effects are rare but can include allergic reactions and kidney problems.
What are the important safety warnings and contraindications of Amlodipine and Losartan?
Losartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. It should also be used cautiously in patients with kidney or liver impairment. Amlodipine should be used with caution in patients with severe aortic stenosis, which is a narrowing of the heart's aortic valve, or heart failure. Both medications can cause low blood pressure, so monitoring is important, especially when starting treatment or adjusting doses. Patients should inform their healthcare provider of any existing health conditions to ensure safe use.

Government Approvals

None

WHO Essential Medicine

NO

Known Teratogen

NO

Pharmaceutical Class

Angiotensin 2 Receptor Blocker and Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker

Controlled Drug Substance

NO

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Drug Ingredient

Amlodipine + Losartan

Summary

What conditions are Amlodipine and Losartan used for?
Amlodipine is used to treat high blood pressure, which is also known as hypertension, and certain types of chest pain called angina. Losartan is used for high blood pressure, reducing the risk of stroke in patients with a heart condition called left ventricular hypertrophy, and managing kidney disease in people with type 2 diabetes. Both medications help lower blood pressure and reduce the risk of heart-related complications.
How do Amlodipine and Losartan work in the body?
Amlodipine is a calcium channel blocker, which means it relaxes blood vessels by preventing calcium from entering the cells of the heart and blood vessel walls, leading to lower blood pressure. Losartan is an angiotensin II receptor blocker, which means it blocks a natural substance that narrows blood vessels, allowing blood to flow more easily and reducing blood pressure. Both medications help improve blood flow and reduce the risk of cardiovascular events like heart attacks and strokes.
What are the usual dosages and routes of administration for Amlodipine and Losartan?
Amlodipine is usually started at 5mg once daily, which can be increased to a maximum of 10mg daily based on the patient's response. Losartan is typically taken at 50mg to 100mg once a day for high blood pressure, with doses ranging from 12.5mg to 150mg for heart failure. Both medications are taken orally, meaning by mouth, and can be adjusted based on individual needs and response to treatment.
What are the most commonly observed adverse effects of Amlodipine and Losartan?
Common side effects of Amlodipine include swelling of the ankles, dizziness, and fatigue. For Losartan, side effects may include dizziness, upper respiratory infections, and back pain. Both medications can cause low blood pressure, known as hypotension, and should be used with caution in patients with certain medical conditions. Serious side effects are rare but can include allergic reactions and kidney problems.
What are the important safety warnings and contraindications of Amlodipine and Losartan?
Losartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. It should also be used cautiously in patients with kidney or liver impairment. Amlodipine should be used with caution in patients with severe aortic stenosis, which is a narrowing of the heart's aortic valve, or heart failure. Both medications can cause low blood pressure, so monitoring is important, especially when starting treatment or adjusting doses. Patients should inform their healthcare provider of any existing health conditions to ensure safe use.

Indications and Purpose

What is combination of Amlodipine and Losartan used for?

The combination of Amlodipine and Losartan is used to treat high blood pressure, also known as hypertension. Amlodipine is a type of medication called a calcium channel blocker, which helps to relax and widen blood vessels, making it easier for the heart to pump blood. Losartan is an angiotensin receptor blocker (ARB) that also helps to relax blood vessels by blocking certain chemicals that tighten them. Together, these medications help to lower blood pressure, reducing the risk of heart attacks and strokes.

What is combination of Losartan and Amlodipine used for?

Losartan is indicated for the treatment of high blood pressure, reducing the risk of stroke in patients with left ventricular hypertrophy, and managing kidney disease in people with type 2 diabetes. Amlodipine is used to treat high blood pressure, chronic stable angina, and vasospastic angina. Both medications are effective in lowering blood pressure and can be used in combination with other treatments to manage cardiovascular conditions and reduce the risk of heart-related complications.

How does combination of Amlodipine and Losartan work?

Amlodipine and Losartan are medications often used together to help manage high blood pressure. Amlodipine is a type of drug known as a calcium channel blocker. It works by relaxing the blood vessels, which allows blood to flow more easily and reduces blood pressure. Losartan, on the other hand, is an angiotensin II receptor blocker (ARB). It helps lower blood pressure by preventing blood vessels from narrowing. Together, these medications help to effectively lower blood pressure by relaxing and widening blood vessels, making it easier for the heart to pump blood.

How does combination of Losartan and Amlodipine work?

Losartan works by blocking the action of angiotensin II, a natural substance that narrows blood vessels, thereby allowing blood to flow more easily and reducing blood pressure. Amlodipine, a calcium channel blocker, prevents calcium from entering the cells of the heart and blood vessels, leading to relaxation and dilation of the blood vessels. Both medications help lower blood pressure and improve blood flow, reducing the risk of cardiovascular events such as heart attacks and strokes.

How effective is combination of Amlodipine and Losartan?

The combination of Amlodipine and Losartan is often used to treat high blood pressure (hypertension). Amlodipine is a calcium channel blocker, which helps relax and widen blood vessels, making it easier for the heart to pump blood. Losartan is an angiotensin receptor blocker (ARB) that also helps relax blood vessels by blocking a substance in the body that causes them to tighten. Together, these medications can be more effective in lowering blood pressure than when used alone. This combination can help reduce the risk of heart attacks, strokes, and kidney problems by effectively managing blood pressure levels. However, the effectiveness can vary based on individual health conditions and should be monitored by a healthcare professional. For more detailed information, you can refer to trusted sources like the [NHS](https://www.nhs.uk/) or [NLM](https://www.nlm.nih.gov/).

How effective is combination of Losartan and Amlodipine?

Clinical trials have demonstrated the effectiveness of both Losartan and Amlodipine in lowering blood pressure and reducing cardiovascular risks. Losartan has been shown to decrease the risk of stroke in patients with hypertension and left ventricular hypertrophy, and it slows the progression of kidney disease in type 2 diabetes patients. Amlodipine effectively reduces blood pressure and alleviates symptoms of angina. Both medications have been proven to improve cardiovascular outcomes, with their benefits supported by extensive research and clinical use.

How does one know if combination of Amlodipine and Losartan is working?

To determine if the combination of Amlodipine and Losartan is working, you should monitor your blood pressure regularly. These medications are used to lower high blood pressure, so a decrease in your blood pressure readings towards the target set by your healthcare provider indicates that the treatment is effective. Additionally, you may notice a reduction in symptoms associated with high blood pressure, such as headaches or dizziness. It's important to follow up with your doctor, who may perform additional tests or assessments to ensure the medication is working as intended. Always consult your healthcare provider before making any changes to your medication regimen.

How does one know if combination of Losartan and Amlodipine is working?

The benefits of Losartan and Amlodipine are primarily assessed by monitoring blood pressure levels. Regular blood pressure checks help determine the effectiveness of the medications in lowering blood pressure to target levels. Additionally, healthcare providers may evaluate kidney function, heart health, and the occurrence of any side effects. For Losartan, blood tests may be conducted to monitor kidney function and potassium levels, while Amlodipine's effectiveness is often gauged by improvements in symptoms of angina and overall cardiovascular health.

Directions for Use

What is the usual dose of combination of Amlodipine and Losartan?

The usual dose of a combination of Amlodipine and Losartan can vary based on individual health needs and the specific formulation prescribed by a healthcare provider. Generally, Amlodipine is available in doses of 5 mg or 10 mg, and Losartan is available in doses of 50 mg or 100 mg. A healthcare provider will determine the appropriate combination and dosage based on factors like blood pressure levels and response to treatment. It's important to follow the prescribed dosage and consult a healthcare provider for personalized advice. For more detailed information, you can refer to trusted sources like the NHS or DailyMeds.

What is the usual dose of combination of Losartan and Amlodipine?

The usual adult daily dose for Losartan is 50mg to 100mg once a day for high blood pressure, while for heart failure, it ranges from 12.5mg to 150mg. For Amlodipine, the typical starting dose is 5mg once daily, which can be increased to a maximum of 10mg daily depending on the patient's response. Both medications are taken orally and can be adjusted based on individual needs and response to treatment. They are often used in combination with other medications to achieve optimal blood pressure control.

How does one take combination of Amlodipine and Losartan?

Amlodipine and Losartan are medications used to treat high blood pressure. Amlodipine is a calcium channel blocker, which helps relax and widen blood vessels, while Losartan is an angiotensin receptor blocker, which also helps relax blood vessels by blocking a substance that causes them to tighten. When taking these medications together, it is important to follow your healthcare provider's instructions. Typically, they are taken once daily, with or without food. It's crucial to take them at the same time each day to maintain an even level in your bloodstream. Always check with your healthcare provider or pharmacist if you have any questions about your dosage or if you experience any side effects. Do not stop taking these medications without consulting your healthcare provider, as this could lead to a sudden increase in blood pressure.

How does one take combination of Losartan and Amlodipine?

Losartan and Amlodipine can both be taken with or without food, making them convenient for daily use. It's important to take them at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium while on Losartan, as it can increase potassium levels. There are no specific food restrictions for Amlodipine, but patients should follow any dietary advice given by their healthcare provider to manage blood pressure effectively.

For how long is combination of Amlodipine and Losartan taken?

The combination of Amlodipine and Losartan is typically taken as a long-term treatment. These medications are used to manage high blood pressure (hypertension) and sometimes other heart-related conditions. The duration of treatment can vary depending on individual health needs and how well the blood pressure is controlled. It's important to follow your healthcare provider's instructions and not to stop taking the medication without consulting them, as this could lead to a return of high blood pressure or other complications. Regular check-ups with your healthcare provider will help determine the appropriate length of treatment for your specific situation.

For how long is combination of Losartan and Amlodipine taken?

Both Losartan and Amlodipine are typically used for long-term treatment of high blood pressure and related conditions. Patients may need to take these medications for the rest of their lives to manage their blood pressure effectively. Regular monitoring by a healthcare provider is essential to ensure the medications are working as intended and to adjust dosages if necessary. Consistent use is crucial for maintaining the benefits of these medications.

How long does it take for combination of Amlodipine and Losartan to work?

Amlodipine and Losartan are medications used to treat high blood pressure. Amlodipine is a calcium channel blocker, which helps relax blood vessels, while Losartan is an angiotensin receptor blocker, which also helps to relax blood vessels and lower blood pressure. According to the NHS, it may take a few weeks to see the full effect of these medications on blood pressure. However, some people may start to notice a reduction in blood pressure within a few days. It's important to continue taking the medication as prescribed and attend follow-up appointments to monitor your blood pressure. For more detailed information, you can visit trusted sources like the NHS or NLM websites.

How long does it take for combination of Losartan and Amlodipine to work?

Losartan and Amlodipine both work to lower blood pressure, but they have different onset times. Losartan may start to lower blood pressure within a week, but it can take 3 to 6 weeks to see the full effect. Amlodipine, on the other hand, begins to work within a few hours, with peak effects occurring within 6 to 12 hours. Both medications are used for long-term management of hypertension, and their effects are sustained with regular use. While Losartan works by blocking substances that tighten blood vessels, Amlodipine relaxes blood vessels by blocking calcium channels.

How does one store combination of Amlodipine and Losartan?

To store a combination of Amlodipine and Losartan, keep the medication in its original container, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom). Make sure to follow any specific storage instructions provided by your pharmacist or on the medication label. Proper storage helps maintain the effectiveness of the medication.

How does one store combination of Losartan and Amlodipine?

Losartan and Amlodipine do not require refrigeration. They should be stored at room temperature, away from excess heat, light, and moisture. It's important to keep them in their original containers, tightly closed, and out of reach of children. Proper storage ensures the medications maintain their effectiveness and safety over time.

Warnings and Precautions

Are there harms and risks from taking combination of Amlodipine and Losartan?

Amlodipine and Losartan are medications often used together to manage high blood pressure. Amlodipine is a calcium channel blocker, which helps relax blood vessels, while Losartan is an angiotensin receptor blocker, which also helps lower blood pressure by relaxing blood vessels. According to the NHS and other trusted sources, taking these medications together is generally safe and can be effective in controlling blood pressure. However, there are potential risks and side effects to be aware of: 1. **Low Blood Pressure (Hypotension):** The combination can sometimes lower blood pressure too much, leading to dizziness or fainting. 2. **Kidney Function:** Both drugs can affect kidney function, so regular monitoring by a healthcare provider is important. 3. **Electrolyte Imbalance:** Losartan can affect potassium levels in the blood, potentially leading to high potassium levels, which can be dangerous. 4. **Swelling (Edema):** Amlodipine can cause swelling, particularly in the ankles and feet. It's important to follow your healthcare provider's instructions and report any unusual symptoms. Regular check-ups can help manage these risks effectively.

Are there harms and risks from taking combination of Losartan and Amlodipine?

Common side effects of Losartan include dizziness, upper respiratory infections, and back pain, while Amlodipine may cause swelling of the ankles, dizziness, and fatigue. Both medications can cause hypotension (low blood pressure) and should be used with caution in patients with certain medical conditions. Serious adverse effects, though rare, can include allergic reactions, kidney problems, and significant drops in blood pressure. Patients should report any unusual symptoms to their healthcare provider promptly.

Can I take combination of Amlodipine and Losartan with other prescription drugs?

Amlodipine and Losartan are medications used to treat high blood pressure. Amlodipine is a calcium channel blocker, which helps relax blood vessels, while Losartan is an angiotensin receptor blocker, which also helps lower blood pressure by relaxing blood vessels. According to the NHS, it is generally safe to take Amlodipine and Losartan together, but you should always consult with your healthcare provider before combining them with other prescription drugs. This is because combining these medications with other drugs can sometimes lead to interactions that may affect how well the drugs work or increase the risk of side effects. For example, taking Amlodipine or Losartan with other blood pressure medications can lower your blood pressure too much, leading to dizziness or fainting. Additionally, certain medications like non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the effectiveness of Losartan. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment. For more detailed information, you can refer to resources like the NHS or DailyMeds.

Can I take combination of Losartan and Amlodipine with other prescription drugs?

Losartan can interact with other blood pressure medications, NSAIDs, and lithium, potentially affecting kidney function and blood pressure control. Amlodipine may interact with other antihypertensives, increasing the risk of hypotension, and with CYP3A inhibitors, which can increase its levels in the blood. Both medications require careful monitoring when used with other drugs that affect blood pressure or kidney function to avoid adverse effects and ensure effective treatment.

Can I take combination of Amlodipine and Losartan with vitamins or supplements?

Yes, you can generally take Amlodipine and Losartan with vitamins or supplements. However, it's important to be cautious with certain supplements that may affect blood pressure or interact with these medications. For example, potassium supplements should be used carefully, as Losartan can increase potassium levels in the blood. Always consult with a healthcare provider before adding any new vitamins or supplements to your routine to ensure they are safe and won't interfere with your medications.

Can I take combination of Losartan and Amlodipine with vitamins or supplements?

Losartan may interact with potassium supplements or salt substitutes containing potassium, potentially leading to hyperkalemia (high potassium levels). Amlodipine does not have significant interactions with vitamins or supplements, but patients should always inform their healthcare provider about all supplements they are taking. It's important to monitor potassium levels when taking Losartan, especially if using supplements that affect potassium balance.

Can I take combination of Amlodipine and Losartan if I am pregnant?

It is generally not recommended to take Losartan during pregnancy. Losartan is part of a group of medications called angiotensin II receptor blockers (ARBs), which can harm the developing baby, especially in the second and third trimesters. Amlodipine, a calcium channel blocker, may be used during pregnancy if the benefits outweigh the risks, but it is important to consult with a healthcare provider. Always discuss with your doctor before taking any medication during pregnancy to ensure the safety of you and your baby.

Can I take combination of Losartan and Amlodipine if I am pregnant?

Losartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including kidney and lung damage. Amlodipine's safety during pregnancy is not well established, and it should only be used if the potential benefits justify the risks. Pregnant women should consult their healthcare provider to discuss alternative treatments for managing high blood pressure during pregnancy.

Can I take combination of Amlodipine and Losartan while breastfeeding?

According to the NHS, Amlodipine is generally considered safe to use while breastfeeding. However, it is always important to consult with a healthcare provider to ensure it is appropriate for your specific situation. Losartan, on the other hand, is not recommended during breastfeeding. The NLM states that there is limited information on the use of Losartan while breastfeeding, and it may pose risks to the infant. Therefore, it is crucial to discuss with your doctor before taking Losartan if you are breastfeeding. In summary, while Amlodipine might be safe, Losartan is generally not advised during breastfeeding. Always consult your healthcare provider for personalized advice.

Can I take combination of Losartan and Amlodipine while breastfeeding?

Losartan is not recommended during breastfeeding due to the lack of data on its safety and potential effects on the infant. Amlodipine is present in breast milk in small amounts, and while no adverse effects have been observed in breastfed infants, caution is advised. Mothers should discuss the risks and benefits with their healthcare provider to determine the best course of action while breastfeeding.

Who should avoid taking combination of Amlodipine and Losartan?

People who should avoid taking the combination of Amlodipine and Losartan include those with certain medical conditions or who are taking specific medications that may interact negatively. According to trusted sources like the NHS and DailyMeds, individuals with severe liver or kidney problems, low blood pressure, or a history of allergic reactions to either drug should be cautious. Additionally, pregnant women or those planning to become pregnant should avoid this combination, as it can harm the developing fetus. It's important for anyone considering this medication combination to consult with a healthcare provider to ensure it's safe for their specific health situation.

Who should avoid taking combination of Losartan and Amlodipine?

Losartan is contraindicated in pregnancy due to the risk of fetal harm, and caution is advised in patients with kidney or liver impairment. Amlodipine should be used cautiously in patients with severe aortic stenosis or heart failure. Both medications can cause hypotension, so patients should be monitored for signs of low blood pressure, especially when starting treatment or adjusting doses. Patients should inform their healthcare provider of any existing health conditions to ensure safe use.