Pathophysiology of Typhoid Fever!

Typhoid fever is a serious illness caused by a bacteria called Salmonella typhi. When these bacteria enter the body, they are swallowed and taken up by cells in the gut. These cells then pass the bacteria to other immune cells in the gut lining. The bacteria use fimbriae(hair like structure) to stick to the gut wall, helping them to grow and cause infection. 
 

The bacteria have certain traits that make them harmful. For example, they produce a substance called Vi antigen that helps them avoid being eaten by immune cells. They also have flagella that allow them to move around and attach to the gut lining. These traits help the bacteria invade the body and cause disease. 
 

Typhoid fever usually starts with stomach problems and then progresses to a high fever, headache, and belly pain. In severe cases, it can lead to serious complications like blood infections, heart problems, pneumonia, and infections in other organs. Some people who get typhoid fever can become carriers of the bacteria even after they recover, spreading the infection without showing symptoms. 
 

Watch our next video to know about ”Drugs Used for Treatment of Typhoid Fever! 
 

Source1:-(n.d.). Retrieved March 7, 2024, from https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/typhoid-fever 
 

Source2:-Bhandari J, Thada PK, DeVos E. Typhoid Fever. [Updated 2022 Aug 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557513/ 
 

Disclaimer:-This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment.Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.

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