Indapamide + Perindopril
Find more information about this combination medication at the webpages for indapamide and perindopril
Hypertension, Left Ventricular Dysfunction ... show more
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Advisory
- This medicine contains a combination of 2 drugs indapamide and perindopril.
- indapamide and perindopril are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor and Thiazide-like Diuretic
Controlled Drug Substance
NO
indapamide + perindopril
Summary
Indapamide and perindopril are primarily used to treat high blood pressure, which is also known as hypertension. Indapamide may also help reduce fluid retention in conditions like heart failure, which is when the heart doesn't pump blood as well as it should. Perindopril can also be used to protect the heart after a heart attack, which is when blood flow to the heart is blocked, and to treat heart failure.
Indapamide works as a diuretic, which is a type of medicine that helps the body get rid of extra salt and water, reducing fluid retention and lowering blood pressure. Perindopril is an ACE inhibitor, which means it blocks a chemical that tightens blood vessels, helping them relax and making it easier for the heart to pump blood, which also helps lower blood pressure.
The usual adult daily dose of indapamide is typically 1.25 mg to 2.5 mg taken once daily. For perindopril, the usual starting dose is 4 mg once daily, which may be adjusted based on the individual's response and needs. Both medicines are taken orally, which means by mouth, usually in the morning. It's important to follow the healthcare provider's instructions regarding dosage.
Common side effects of indapamide include dizziness, headache, and fatigue, which are related to its diuretic effect. Perindopril may cause a persistent dry cough, dizziness, and fatigue due to its action on blood vessels. Both medicines can lead to low blood pressure, which may cause dizziness or fainting. Monitoring is important to manage these side effects effectively.
Indapamide and perindopril should not be used by individuals with a known allergy to these medicines. Perindopril is contraindicated in pregnancy due to the risk of fetal harm. Indapamide should be used cautiously in people with severe kidney or liver disease. Both medicines can cause low blood pressure, so they should be used carefully in individuals prone to hypotension. Regular monitoring of blood pressure and kidney function is important.
Indications and Purpose
How does combination of indapamide and perindopril work?
Indapamide works by increasing the amount of urine produced, which helps remove excess fluid from the body and lowers blood pressure. It acts as a diuretic, which is a type of medicine that helps the body get rid of extra salt and water. Perindopril works by relaxing blood vessels, making it easier for the heart to pump blood, which also helps lower blood pressure. It is an ACE inhibitor, which means it blocks a chemical that tightens blood vessels. Together, they help manage high blood pressure by reducing fluid and relaxing blood vessels.
How does combination of Indapamide and Perindopril work?
The combination of Indapamide and Perindopril is used to treat high blood pressure. Indapamide is a type of medication known as a diuretic, or 'water pill,' which helps the body get rid of excess salt and water by increasing urine production. This helps to lower blood pressure by reducing the volume of fluid in the blood vessels. Perindopril is an ACE inhibitor, which stands for angiotensin-converting enzyme inhibitor. It works by relaxing blood vessels, making it easier for the heart to pump blood through the body. By combining these two medications, the treatment effectively reduces blood pressure by both decreasing fluid volume and relaxing blood vessels, which can help prevent heart attacks and strokes.
How does combination of Perindopril and Indapamide work?
Perindopril works by inhibiting the angiotensin-converting enzyme (ACE), which leads to the relaxation of blood vessels and a reduction in blood pressure. Indapamide acts as a diuretic, increasing urine production to help reduce fluid retention and lower blood pressure. Both medications help decrease the workload on the heart and improve blood flow, but they do so through different mechanisms. Together, they provide a synergistic effect in managing hypertension.
How effective is combination of indapamide and perindopril?
Clinical studies have shown that indapamide effectively reduces blood pressure by removing excess fluid, which helps decrease the workload on the heart. Perindopril has been proven to lower blood pressure by relaxing blood vessels, making it easier for the heart to pump blood. Together, these medicines have been shown to effectively manage high blood pressure, with indapamide providing quick relief from fluid retention and perindopril offering long-term blood pressure control. Both medicines are well-documented in their ability to improve cardiovascular health.
How effective is combination of Indapamide and Perindopril?
The combination of Indapamide and Perindopril is often used to treat high blood pressure (hypertension). Indapamide is a diuretic, which means it helps the body get rid of excess salt and water by increasing urine production. This can help lower blood pressure. Perindopril is an ACE inhibitor, which helps relax blood vessels, making it easier for the heart to pump blood. Together, these medications can be more effective in lowering blood pressure than when used alone. According to the NHS, this combination is generally well-tolerated and can significantly reduce the risk of heart attacks and strokes in people with high blood pressure. However, as with any medication, effectiveness can vary from person to person, and it's important to follow a healthcare provider's guidance when using these medications.
How effective is combination of Perindopril and Indapamide?
Clinical trials have demonstrated the effectiveness of Perindopril and Indapamide in lowering blood pressure and reducing cardiovascular risks. Perindopril has been shown to significantly reduce the risk of cardiovascular mortality and nonfatal myocardial infarction in patients with stable coronary artery disease. Indapamide effectively reduces blood pressure and fluid retention, particularly in patients with hypertension and congestive heart failure. Both medications have been proven to provide significant antihypertensive effects, either alone or in combination with other treatments, offering a comprehensive approach to managing high blood pressure.
Directions for Use
What is the usual dose of combination of indapamide and perindopril?
The usual adult daily dose of indapamide is typically 1.25 mg to 2.5 mg taken once daily. For perindopril, the usual starting dose is 4 mg once daily, which may be adjusted based on the individual's response and needs. Both medicines are taken orally, usually in the morning. It's important to follow the healthcare provider's instructions regarding dosage to ensure the medicines are effective and to minimize the risk of side effects.
What is the usual dose of combination of Indapamide and Perindopril?
The usual dose of the combination of Indapamide and Perindopril can vary based on individual health needs and the specific formulation prescribed by a healthcare provider. Typically, this combination is used to treat high blood pressure. Indapamide is a diuretic, which helps reduce excess fluid in the body, while Perindopril is an ACE inhibitor that helps relax blood vessels. It's important to follow the dosage instructions provided by your doctor or pharmacist, as they will tailor the dose to your specific condition. Always consult with a healthcare professional before starting or adjusting any medication.
What is the usual dose of combination of Perindopril and Indapamide?
For Perindopril, the usual starting dose for hypertension is 4 mg once daily, which can be adjusted up to a maximum of 16 mg per day based on the patient's response. For Indapamide, the typical starting dose for hypertension is 1.25 mg once daily, which can be increased to 2.5 mg if needed. Both medications are taken orally and are often adjusted based on the patient's blood pressure response and tolerance. It's important to follow a healthcare provider's instructions for dosing adjustments.
How does one take combination of indapamide and perindopril?
Indapamide and perindopril can be taken with or without food, but it's important to take them at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but it's advisable to avoid excessive salt intake, as it can counteract the effects of these medicines. Drinking plenty of water is recommended to stay hydrated, especially when taking indapamide, which increases urine production. Always follow the healthcare provider's instructions for best results.
How does one take combination of Indapamide and Perindopril?
Indapamide and Perindopril are medications often prescribed together to manage high blood pressure. Indapamide is a diuretic, which helps reduce excess fluid in the body, while Perindopril is an ACE inhibitor that helps relax blood vessels. According to the NHS, these medications are usually taken once a day, preferably in the morning. It's important to take them at the same time each day to maintain an even level in your bloodstream. You can take them with or without food, but try to be consistent with your choice. The DailyMeds website advises that you should swallow the tablets whole with a glass of water. Do not crush or chew them, as this can affect how the medication is absorbed in your body. Always follow the dosage instructions provided by your healthcare provider, and do not stop taking the medication without consulting them, even if you feel well. Regular monitoring of your blood pressure and kidney function may be necessary while on these medications. If you experience any side effects or have concerns about taking these medications, contact your healthcare provider for advice.
How does one take combination of Perindopril and Indapamide?
Perindopril and Indapamide can be taken with or without food, but it's important to take them consistently at the same time each day. Patients should avoid high-salt diets, as salt can counteract the effects of these medications. It's also advisable to limit alcohol consumption, as it can increase the risk of side effects like dizziness. Regular monitoring of blood pressure and kidney function is recommended to ensure the medications are working effectively and safely.
For how long is combination of indapamide and perindopril taken?
Indapamide and perindopril are typically used for long-term management of high blood pressure. The duration of use depends on the individual's response and the healthcare provider's recommendations. These medicines are often taken indefinitely to maintain blood pressure control and reduce the risk of complications. Regular follow-up with a healthcare provider is important to monitor effectiveness and adjust treatment as needed.
For how long is combination of Indapamide and Perindopril taken?
The combination of Indapamide and Perindopril is typically taken as a long-term treatment. This combination is often prescribed to manage high blood pressure (hypertension) and may be taken indefinitely to maintain blood pressure control. However, the exact duration of treatment should be determined by a healthcare professional based on individual health needs and response to the medication. Regular check-ups are important to assess the effectiveness and adjust the treatment as necessary. Always follow the advice of your doctor regarding the duration of any medication.
For how long is combination of Perindopril and Indapamide taken?
Perindopril and Indapamide are typically used as long-term treatments for hypertension and related conditions. The duration of use is often indefinite, as these medications are intended to manage chronic conditions rather than cure them. Regular monitoring by a healthcare provider is essential to ensure the medications are effective and to adjust dosages as needed. Both medications require consistent daily use to maintain their therapeutic effects.
How long does it take for combination of indapamide and perindopril to work?
Indapamide, which is a diuretic, typically starts working within a few hours to help reduce fluid retention and lower blood pressure. Perindopril, which is an ACE inhibitor, may take a few days to a week to show its full effect in lowering blood pressure. Together, these medicines work to manage high blood pressure, but the time it takes to notice a change can vary. Indapamide acts quickly to remove excess fluid, while perindopril gradually helps relax blood vessels.
How long does it take for combination of Indapamide and Perindopril to work?
The combination of Indapamide and Perindopril is used to treat high blood pressure. Indapamide is a diuretic, which helps remove excess fluid from the body, and Perindopril is an ACE inhibitor, which helps relax blood vessels. According to the NHS, it may take a few weeks to see the full effect of these medications on blood pressure. However, some people may notice an improvement in their blood pressure within a few days. It's important to continue taking the medication as prescribed and consult with a healthcare provider for personalized advice.
How long does it take for combination of Perindopril and Indapamide to work?
Perindopril and Indapamide both work to lower blood pressure, but they do so in different ways. Perindopril, an ACE inhibitor, typically starts to work within a few hours, with peak effects seen after several weeks of consistent use. Indapamide, a diuretic, also begins to act within a few hours, helping to reduce fluid retention and lower blood pressure. Both medications are absorbed quickly, but their full therapeutic effects may take a few weeks to become apparent. The combination of these two medicines can provide a more comprehensive approach to managing hypertension.
Warnings and Precautions
Are there harms and risks from taking combination of indapamide and perindopril?
Common side effects of indapamide include dizziness, headache, and fatigue, which are related to its diuretic effect. Perindopril may cause a persistent dry cough, dizziness, and fatigue due to its action on blood vessels. Both medicines can lead to low blood pressure, which may cause dizziness or fainting. Significant adverse effects include electrolyte imbalances from indapamide and angioedema, which is swelling under the skin, from perindopril. Monitoring is important to manage these side effects effectively.
Are there harms and risks from taking combination of Indapamide and Perindopril?
Taking Indapamide and Perindopril together can have potential risks and side effects. Indapamide is a diuretic, which means it helps your body get rid of excess salt and water by making you urinate more. Perindopril is an ACE inhibitor, which helps relax blood vessels and lower blood pressure. When used together, they can effectively lower blood pressure, but they may also increase the risk of certain side effects. These can include dizziness, especially when standing up quickly, due to a drop in blood pressure. There is also a risk of dehydration and an imbalance in electrolytes, which are minerals in your blood that are important for your body's functions. Additionally, combining these medications can sometimes lead to kidney problems, so regular monitoring by a healthcare provider is important. It's crucial to follow your doctor's instructions and report any unusual symptoms, such as severe dizziness, muscle cramps, or changes in urination, to ensure safe use of these medications. For more detailed information, you can refer to trusted sources like the NHS, DailyMeds, or the National Library of Medicine (NLM).
Are there harms and risks from taking combination of Perindopril and Indapamide?
Common side effects of Perindopril include cough, dizziness, and headache. Indapamide may cause side effects such as dizziness, headache, and fatigue. Both medications can lead to electrolyte imbalances, such as low potassium levels, and may cause hypotension, especially when starting treatment or adjusting doses. Serious adverse effects can include angioedema with Perindopril and severe hyponatremia with Indapamide. Regular monitoring of blood pressure and electrolytes is important to manage these potential side effects.
Can I take combination of indapamide and perindopril with other prescription drugs?
Indapamide and perindopril can interact with other blood pressure medications, increasing the risk of low blood pressure. They may also interact with non-steroidal anti-inflammatory drugs (NSAIDs), which can reduce their effectiveness and affect kidney function. Combining these medicines with lithium can increase lithium levels, leading to toxicity. It's important to inform healthcare providers of all prescription medications being taken to avoid potential interactions and ensure safe use. Regular monitoring of blood pressure and kidney function is recommended.
Can I take combination of Indapamide and Perindopril with other prescription drugs?
Indapamide and Perindopril are medications often used together to manage high blood pressure. However, combining them with other prescription drugs can sometimes lead to interactions that may affect how well the drugs work or increase the risk of side effects. According to the NHS, it's important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements. This helps them assess any potential interactions. The NLM notes that Indapamide is a diuretic, which means it helps remove excess fluid from the body, while Perindopril is an ACE inhibitor, which helps relax blood vessels. Both can interact with other medications, such as other blood pressure drugs, lithium, or non-steroidal anti-inflammatory drugs (NSAIDs). DailyMeds suggests that before starting any new medication, you should consult with your healthcare provider to ensure it's safe to use with your current treatment plan. They can provide guidance tailored to your specific health needs.
Can I take combination of Perindopril and Indapamide with other prescription drugs?
Perindopril can interact with diuretics, increasing the risk of hypotension, and with lithium, potentially leading to lithium toxicity. Indapamide may interact with other antihypertensive drugs, enhancing their effects, and with lithium, increasing the risk of toxicity. Both medications can interact with non-steroidal anti-inflammatory drugs (NSAIDs), which may reduce their effectiveness and increase the risk of kidney damage. It's important to inform healthcare providers of all medications being taken to manage these interactions effectively.
Can I take combination of indapamide and perindopril if I am pregnant?
Indapamide and perindopril are generally not recommended during pregnancy. Perindopril, as an ACE inhibitor, can cause harm to the developing fetus, especially in the second and third trimesters, leading to potential birth defects or complications. Indapamide's safety during pregnancy is not well-established, and it may affect fluid balance in the mother and fetus. If a woman becomes pregnant while taking these medicines, she should consult her healthcare provider immediately to discuss alternative treatments.
Can I take combination of Indapamide and Perindopril if I am pregnant?
It is generally not recommended to take Indapamide and Perindopril during pregnancy. According to the NHS, Perindopril, which is an ACE inhibitor, can affect the baby's development, especially if taken during the second and third trimesters. Indapamide, a diuretic, may also pose risks during pregnancy. It is crucial to consult with a healthcare provider to discuss safer alternatives for managing your condition while pregnant.
Can I take combination of Perindopril and Indapamide if I am pregnant?
Perindopril is classified as pregnancy category D, indicating potential risk to the fetus, particularly in the second and third trimesters, due to its effects on the renin-angiotensin system. Indapamide should be used during pregnancy only if clearly needed, as diuretics can cross the placental barrier and may pose risks to the fetus. Both medications are generally not recommended during pregnancy, and alternative treatments should be considered. Pregnant women should consult their healthcare provider to discuss potential risks and alternative options.
Can I take combination of indapamide and perindopril while breastfeeding?
The safety of indapamide and perindopril during breastfeeding is not well-established. Indapamide may pass into breast milk and affect the infant's fluid balance. Perindopril may also be present in breast milk, potentially affecting the infant's blood pressure. Due to these concerns, breastfeeding mothers should consult their healthcare provider to weigh the benefits and risks of continuing these medications while nursing. Alternative treatments may be recommended to ensure the safety of the infant.
Can I take combination of Indapamide and Perindopril while breastfeeding?
According to the NHS, it is important to consult with a healthcare professional before taking any medication while breastfeeding. Indapamide and Perindopril are medications used to treat high blood pressure. Indapamide is a diuretic, which helps the body get rid of excess salt and water, while Perindopril is an ACE inhibitor, which helps relax blood vessels. The safety of these medications during breastfeeding is not well established. The NHS advises that some medications can pass into breast milk and may affect the baby. Therefore, it is crucial to discuss with your doctor or a healthcare provider to weigh the benefits and potential risks before taking these medications while breastfeeding.
Can I take combination of Perindopril and Indapamide while breastfeeding?
The safety of Perindopril and Indapamide during lactation is not well established. Perindopril is known to be excreted in animal milk, and while it's unclear if it appears in human milk, caution is advised. Indapamide's excretion in human milk is also unknown, but due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or the drug, considering the importance of the medication to the mother. Consulting a healthcare provider is essential for breastfeeding mothers.
Who should avoid taking combination of indapamide and perindopril?
Indapamide and perindopril should not be used by individuals with a known allergy to these medicines. Perindopril is contraindicated in pregnancy due to the risk of fetal harm. Indapamide should be used cautiously in people with severe kidney or liver disease. Both medicines can cause low blood pressure, so they should be used carefully in individuals prone to hypotension. Regular monitoring of blood pressure and kidney function is important to ensure safe use. Patients should discuss their medical history with their healthcare provider before starting these medications.
Who should avoid taking combination of Indapamide and Perindopril?
People who should avoid taking the combination of Indapamide and Perindopril include: 1. **Pregnant Women**: This combination can harm the developing baby, especially in the second and third trimesters. 2. **Individuals with Severe Kidney Problems**: Since these drugs can affect kidney function, those with severe kidney issues should avoid them. 3. **People with Low Blood Pressure**: The combination can further lower blood pressure, which might be dangerous. 4. **Patients with Allergies to Sulfonamides**: Indapamide is a sulfonamide, and those allergic to this class of drugs should avoid it. 5. **Individuals with Angioedema**: Those who have experienced angioedema (swelling under the skin) related to previous ACE inhibitor use should not take Perindopril. 6. **People with Hyperkalemia**: This is a condition where there is too much potassium in the blood, and Perindopril can increase potassium levels. Always consult a healthcare provider before starting or stopping any medication.
Who should avoid taking combination of Perindopril and Indapamide?
Perindopril is contraindicated in patients with a history of angioedema related to previous ACE inhibitor treatment. Indapamide is contraindicated in patients with anuria or known hypersensitivity to sulfonamide-derived drugs. Both medications should be used cautiously in patients with renal impairment, as they can affect kidney function. They are also not recommended during pregnancy due to potential harm to the fetus. Regular monitoring of blood pressure, kidney function, and electrolytes is essential to ensure safe use.
