Perindopril
Hypertension, Left Ventricular Dysfunction ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Possible
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor
Controlled Drug Substance
No
perindopril
Summary
Perindopril is used to treat high blood pressure, which is called hypertension, and heart failure, which is when the heart can't pump blood effectively. It helps lower blood pressure and reduces the workload on the heart, improving heart function and preventing complications like heart attacks and strokes.
Perindopril is an ACE inhibitor, which means it blocks a chemical that tightens blood vessels. This action relaxes the blood vessels, lowering blood pressure and making it easier for the heart to pump blood, reducing the risk of heart-related problems.
The usual starting dose of Perindopril for adults is 4 mg once daily, with a maximum recommended dose of 16 mg per day. It is taken orally, preferably in the morning, with or without food. Always follow your doctor's specific dosing instructions.
Common side effects of Perindopril include dizziness, cough, and fatigue. These effects are usually mild. Serious adverse effects, though rare, include angioedema, which is swelling of the face or throat, and kidney problems. Contact your doctor if you notice any new or worsening symptoms.
Perindopril can cause a severe allergic reaction called angioedema, which involves swelling of the face, lips, or throat. It can also affect kidney function and increase potassium levels. It's not recommended during pregnancy or for people with a history of angioedema. Always consult your doctor about these concerns.
Indications and Purpose
How does Perindopril work?
Perindopril is an ACE inhibitor, which means it blocks a chemical in your body that tightens blood vessels. Think of it like loosening a tight belt. By relaxing the blood vessels, Perindopril lowers blood pressure and makes it easier for your heart to pump blood. This helps reduce the risk of heart-related problems and improves heart function in people with heart failure.
Is Perindopril effective?
Perindopril is effective in treating high blood pressure, which is called hypertension, and heart failure, which is when your heart can't pump blood effectively. It works by relaxing blood vessels, which lowers blood pressure and reduces the workload on the heart. Clinical studies show that Perindopril significantly improves blood pressure control and reduces the risk of heart-related events. These results support its effectiveness in managing these conditions.
What is Perindopril?
Perindopril is a medication used to treat high blood pressure, which is called hypertension, and heart failure, which is when your heart can't pump blood effectively. It belongs to a class of drugs called ACE inhibitors, which work by relaxing blood vessels to lower blood pressure. This helps reduce the workload on the heart. Perindopril is often used alone or with other medications to manage these conditions.
Directions for Use
For how long do I take Perindopril?
Perindopril is usually a long-term medication for managing ongoing health conditions like high blood pressure and heart failure. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health.
How do I dispose of Perindopril?
Bring unused Perindopril to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Perindopril?
Take Perindopril once daily, preferably in the morning. You can take it with or without food. Swallow the tablet whole; do not crush it. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Avoid alcohol, as it can increase the risk of side effects like dizziness. Always follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
How long does it take for Perindopril to start working?
Perindopril starts working within a few hours of taking it, but it may take several weeks to achieve its full therapeutic effect. The time it takes to work can depend on individual factors like your age, kidney function, and overall health. Regular monitoring of your blood pressure will help determine how well the medication is working. Take it exactly as prescribed for the best results.
How should I store Perindopril?
Store Perindopril tablets at room temperature, away from moisture and light. Keep them in a tightly closed container. Do not store them in humid places like bathrooms, as moisture can affect how well the medication works. Always store Perindopril out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Perindopril?
The usual starting dose of Perindopril for adults is 4 mg once daily. Your doctor may adjust the dose based on your response and needs, with a maximum recommended dose of 16 mg per day. For elderly patients or those with kidney problems, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can I take Perindopril with other prescription drugs?
Perindopril can interact with other medications, increasing the risk of side effects. Combining it with diuretics, which are water pills, can increase the risk of low blood pressure. Taking it with potassium supplements or potassium-sparing diuretics can lead to high potassium levels, which is called hyperkalemia. Always inform your doctor about all the medications you take to avoid interactions and ensure your treatment is safe.
Can Perindopril be taken safely while breastfeeding?
Perindopril is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. However, it might affect a baby's developing kidneys. If you're taking Perindopril and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Perindopril be taken safely while pregnant?
Perindopril is not recommended during pregnancy, especially in the second and third trimesters. It can harm the developing baby, affecting kidney development and causing low blood pressure. If you're pregnant or planning to become pregnant, talk with your doctor about safer alternatives to manage your condition. They can help create a treatment plan that protects both you and your baby.
Does Perindopril have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Perindopril include dizziness, cough, and fatigue. These effects are usually mild. Serious adverse effects, though rare, include angioedema, which is swelling of the face or throat, and kidney problems. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Perindopril and suggest appropriate actions.
Does Perindopril have any safety warnings?
Yes, Perindopril has important safety warnings. It can cause a severe allergic reaction called angioedema, which involves swelling of the face, lips, or throat. This requires immediate medical attention. Perindopril can also affect kidney function and increase potassium levels, which is called hyperkalemia. Regular monitoring of kidney function and potassium levels is important. If you experience symptoms like swelling, difficulty breathing, or irregular heartbeats, seek medical help right away.
Is it safe to drink alcohol while taking Perindopril?
It's best to limit alcohol while taking Perindopril. Alcohol can increase the risk of side effects like dizziness or low blood pressure. If you choose to drink, do so in moderation and watch for warning signs like dizziness or lightheadedness. Talk with your doctor about alcohol use while taking Perindopril to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Perindopril?
You can exercise while taking Perindopril, but be cautious. This medication can cause dizziness, especially when you stand up quickly. To exercise safely, start slowly and gradually increase intensity. Stay hydrated and watch for signs of dizziness or fatigue. If you notice these symptoms, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Perindopril, but check with your doctor if you have concerns.
Is it safe to stop Perindopril?
Stopping Perindopril suddenly can cause your blood pressure to rise, which may increase the risk of heart problems. It's important to talk with your doctor before stopping this medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Perindopril addictive?
Perindopril is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Perindopril works by relaxing blood vessels to lower blood pressure, which does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Perindopril doesn't carry this risk.
Is Perindopril safe for the elderly?
Elderly people are more vulnerable to the side effects of Perindopril, such as dizziness or kidney problems. This is because their bodies may process medications differently. Perindopril is generally safe for the elderly, but they may need lower doses and careful monitoring. Regular check-ups with a doctor are important to ensure the medication is working safely and effectively.
What are the most common side effects of Perindopril?
Side effects are unwanted reactions to a medication. Common side effects of Perindopril include dizziness, cough, and fatigue. These occur in a small percentage of people and are usually mild. If you experience new symptoms after starting Perindopril, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Perindopril?
Do not take Perindopril if you're allergic to it or its ingredients. Serious allergic reactions, which cause swelling of the face or throat, require immediate medical help. This medication is not for people with a history of angioedema, which is swelling under the skin. Perindopril should be used with caution in people with kidney problems or those taking potassium supplements, as it can increase potassium levels. Always consult your doctor about these concerns.
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