Hydrochlorothiazide + Metoprolol-succinate
Find more information about this combination medication at the webpages for metoprolol succinate and hydrochlorothiazide
Hypertension , Angina Pectoris ... show more
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Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Beta-Adrenergic Blocker and Thiazide Diuretic
Controlled Drug Substance
NO
Summary
Hydrochlorothiazide is used to treat high blood pressure, which is also known as hypertension, and fluid retention, which is called edema, often linked to heart failure or kidney issues. Metoprolol succinate is used for high blood pressure, angina, which is chest pain due to reduced blood flow to the heart, and heart failure. Together, they help manage cardiovascular conditions by lowering blood pressure and reducing the risk of heart attacks and strokes.
Hydrochlorothiazide works by increasing urine production, which helps remove excess fluid and salt, lowering blood pressure. Metoprolol succinate blocks beta receptors in the heart, which reduces heart rate and the force of heart contractions, also helping to lower blood pressure. Together, they address different aspects of blood pressure control, making them effective in managing hypertension.
The usual adult daily dose of hydrochlorothiazide is 12.5 to 50 mg, depending on the condition. Metoprolol succinate is typically dosed at 25 to 100 mg per day, based on individual response. Both medicines are usually taken once daily, with metoprolol succinate taken with or after a meal to enhance absorption. Dosages may be adjusted by a healthcare provider based on patient needs.
Common side effects of hydrochlorothiazide include increased urination and electrolyte imbalances, which are changes in blood mineral levels. Metoprolol succinate may cause fatigue, dizziness, and a slow heart rate, which is due to its action on the heart. Both medicines can cause low blood pressure, which is a shared side effect. Severe reactions should be reported to a healthcare provider.
Hydrochlorothiazide should be used cautiously in people with kidney problems or electrolyte imbalances. Metoprolol succinate is contraindicated in individuals with severe heart block, which is a condition where heart signals are blocked, or severe bradycardia, which is an abnormally slow heart rate. Both medicines should be used with caution in people with low blood pressure. Regular check-ups are important to monitor for issues.
Indications and Purpose
How does combination of Hydrochlorothiazide and Metoprolol succinate work?
Hydrochlorothiazide works by acting as a diuretic, helping the kidneys eliminate excess salt and water from the body, which reduces fluid retention and lowers blood pressure. Metoprolol succinate, a beta-blocker, works by relaxing blood vessels and slowing the heart rate, which improves blood flow and further decreases blood pressure. Both medications are used to manage high blood pressure, but they do so through different mechanisms. Together, they provide a comprehensive approach to controlling hypertension and reducing the risk of cardiovascular complications.
How effective is combination of Hydrochlorothiazide and Metoprolol succinate?
The effectiveness of Hydrochlorothiazide and Metoprolol succinate in managing high blood pressure is supported by clinical trials and studies. Hydrochlorothiazide has been shown to effectively reduce fluid retention and lower blood pressure by promoting the excretion of excess salt and water. Metoprolol succinate has demonstrated efficacy in reducing heart rate, relaxing blood vessels, and improving survival rates after heart attacks. Both medications have been proven to reduce the risk of cardiovascular events, such as strokes and heart attacks, by effectively controlling blood pressure. Their combined use offers a comprehensive approach to hypertension management.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Metoprolol succinate?
The usual adult daily dose for Hydrochlorothiazide ranges from 12.5 mg to 50 mg per day, depending on the condition being treated. For Metoprolol, the initial dose is typically 100 mg daily, which can be taken in single or divided doses. Both medications are used to manage high blood pressure, but Hydrochlorothiazide is a diuretic that helps remove excess fluid, while Metoprolol is a beta-blocker that reduces heart rate and relaxes blood vessels. The combination of these two medications can be more effective in controlling blood pressure than either drug alone.
How does one take combination of Hydrochlorothiazide and Metoprolol succinate?
Hydrochlorothiazide can be taken with or without food, but it's important to follow the specific instructions provided by your healthcare provider. Metoprolol succinate should be taken with or immediately after meals to enhance absorption. Patients are advised to maintain a low-salt diet and may need to increase potassium-rich foods, especially when taking Hydrochlorothiazide, as it can cause potassium loss. It's important to avoid alcohol while taking Metoprolol, as it can enhance side effects like dizziness. Always follow your doctor's dietary recommendations while on these medications.
For how long is combination of Hydrochlorothiazide and Metoprolol succinate taken?
Hydrochlorothiazide and Metoprolol succinate are typically used as long-term treatments for managing high blood pressure and related conditions. Hydrochlorothiazide is often taken daily, while Metoprolol succinate is usually taken once a day. Both medications are intended for continuous use to maintain blood pressure control and prevent complications. It's important to follow the prescribed regimen and not to stop taking these medications without consulting a healthcare provider, as they help manage chronic conditions.
How long does it take for combination of Hydrochlorothiazide and Metoprolol succinate to work?
Hydrochlorothiazide typically begins to work within 2 hours, with its peak effect occurring around 4 hours after administration. Metoprolol, on the other hand, shows significant beta-blocking effects within 1 hour after oral administration. Both medications work relatively quickly to help manage high blood pressure, but their mechanisms differ. Hydrochlorothiazide acts as a diuretic, helping the body eliminate excess salt and water, while Metoprolol is a beta-blocker that relaxes blood vessels and slows the heart rate. Together, they provide a comprehensive approach to lowering blood pressure.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Metoprolol succinate?
Common side effects of Hydrochlorothiazide include frequent urination, diarrhea, and headache, while Metoprolol succinate may cause dizziness, tiredness, and depression. Both medications can lead to more serious adverse effects, such as electrolyte imbalances with Hydrochlorothiazide and shortness of breath or irregular heartbeat with Metoprolol. It's important to monitor for signs of dehydration, low blood pressure, or severe allergic reactions. Patients should report any unusual symptoms to their healthcare provider promptly to ensure safe and effective use of these medications.
Can I take combination of Hydrochlorothiazide and Metoprolol succinate with other prescription drugs?
Hydrochlorothiazide can interact with nonsteroidal anti-inflammatory drugs (NSAIDs), reducing its effectiveness. It also interacts with cholestyramine and colestipol, which can decrease its absorption. Metoprolol succinate can interact with other medications that affect heart rate, such as digitalis glycosides and certain calcium channel blockers, increasing the risk of bradycardia. Both medications can interact with other antihypertensive drugs, potentially leading to excessive blood pressure reduction. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of Hydrochlorothiazide and Metoprolol succinate if I am pregnant?
Hydrochlorothiazide and Metoprolol succinate have been used during pregnancy, but their safety is not fully established. Hydrochlorothiazide may cause electrolyte imbalances in the fetus, while Metoprolol can cross the placenta and may lead to fetal bradycardia or hypoglycemia. Pregnant women with hypertension should be closely monitored, and the potential risks and benefits of these medications should be discussed with a healthcare provider. Alternative treatments may be considered if the risks outweigh the benefits.
Can I take combination of Hydrochlorothiazide and Metoprolol succinate while breastfeeding?
Both Hydrochlorothiazide and Metoprolol succinate are present in breast milk, but there are no reports of adverse effects on breastfed infants. Hydrochlorothiazide in high doses may affect milk production due to its diuretic effect. Metoprolol is generally considered safe during breastfeeding, but infants should be monitored for signs of bradycardia or drowsiness. The benefits of breastfeeding should be weighed against the mother's need for these medications, and any potential effects on the infant should be discussed with a healthcare provider.
Who should avoid taking combination of Hydrochlorothiazide and Metoprolol succinate?
Hydrochlorothiazide is contraindicated in patients with anuria and those allergic to sulfonamide-derived drugs. Metoprolol succinate should not be used in patients with severe bradycardia, heart block, or decompensated heart failure. Both medications require caution in patients with kidney or liver disease. Abrupt discontinuation of Metoprolol can lead to severe heart problems, so it should be tapered off under medical supervision. Patients should be aware of the risk of electrolyte imbalances with Hydrochlorothiazide and the potential for bronchospasm with Metoprolol, especially in those with asthma.
