Hydrochlorothiazide + Losartan

Find more information about this combination medication at the webpages for hydrochlorothiazide and losartan

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Approved Treatment Indication:

Hypertension, Left Ventricular Hypertrophy ... show more

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Advisory

This medicine contains a combination of 2 drugs hydrochlorothiazide and losartan.
hydrochlorothiazide and losartan are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions hydrochlorothiazide and losartan is used for
Hydrochlorothiazide and losartan are used to treat high blood pressure, which is also known as hypertension. By lowering blood pressure, they help reduce the risk of complications such as heart attacks, strokes, and kidney problems. Losartan is also used to protect the kidneys in people with type 2 diabetes who have high blood pressure. Together, they provide a comprehensive approach to managing blood pressure and protecting against related health issues.
How hydrochlorothiazide and losartan works in the body
Hydrochlorothiazide is a diuretic, which helps the body eliminate excess salt and water through urine, reducing fluid buildup and lowering blood pressure. Losartan is an angiotensin receptor blocker, which relaxes blood vessels by blocking a substance that causes them to tighten, helping blood flow more easily and lowering blood pressure. Together, they address both fluid retention and blood vessel constriction, providing a more comprehensive approach to managing high blood pressure.
The usual dosages and routes of administration of hydrochlorothiazide and losartan
The usual adult daily dose for hydrochlorothiazide is typically 12.5 to 25 milligrams, taken once a day. For losartan, the usual starting dose is 50 milligrams once a day, which may be adjusted based on the individual's response and needs. When combined, the doses may vary depending on the specific formulation prescribed by a healthcare provider. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare professional.
The most commonly observed adverse effects of hydrochlorothiazide and losartan
Common side effects of hydrochlorothiazide include increased urination, dizziness, and electrolyte imbalances, which refer to changes in the levels of minerals in the blood. Losartan may cause dizziness, fatigue, and nasal congestion. Both medicines can lead to low blood pressure, which is a significant adverse effect. Rarely, losartan can cause kidney problems or high potassium levels, while hydrochlorothiazide can lead to dehydration. Monitoring for these side effects is important.
Important safety warnings and contraindications of hydrochlorothiazide and losartan
Hydrochlorothiazide and losartan should not be used during pregnancy due to potential harm to the fetus. People with severe kidney or liver problems should use them cautiously. Hydrochlorothiazide can cause electrolyte imbalances, so regular monitoring is necessary. Losartan can lead to high potassium levels, so potassium intake should be monitored. Both medications can cause low blood pressure, especially when combined with other blood pressure-lowering drugs. Inform healthcare providers of any existing health conditions.

Government Approvals

UK(FDA), US(FDA)

WHO Essential Medicine

NO

Known Teratogen

Definite

Pharmaceutical Class

Angiotensin 2 Receptor Blocker and Thiazide Diuretic

Controlled Drug Substance

NO

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Drug Ingredient

hydrochlorothiazide + losartan

Summary

What conditions hydrochlorothiazide and losartan is used for
Hydrochlorothiazide and losartan are used to treat high blood pressure, which is also known as hypertension. By lowering blood pressure, they help reduce the risk of complications such as heart attacks, strokes, and kidney problems. Losartan is also used to protect the kidneys in people with type 2 diabetes who have high blood pressure. Together, they provide a comprehensive approach to managing blood pressure and protecting against related health issues.
How hydrochlorothiazide and losartan works in the body
Hydrochlorothiazide is a diuretic, which helps the body eliminate excess salt and water through urine, reducing fluid buildup and lowering blood pressure. Losartan is an angiotensin receptor blocker, which relaxes blood vessels by blocking a substance that causes them to tighten, helping blood flow more easily and lowering blood pressure. Together, they address both fluid retention and blood vessel constriction, providing a more comprehensive approach to managing high blood pressure.
The usual dosages and routes of administration of hydrochlorothiazide and losartan
The usual adult daily dose for hydrochlorothiazide is typically 12.5 to 25 milligrams, taken once a day. For losartan, the usual starting dose is 50 milligrams once a day, which may be adjusted based on the individual's response and needs. When combined, the doses may vary depending on the specific formulation prescribed by a healthcare provider. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare professional.
The most commonly observed adverse effects of hydrochlorothiazide and losartan
Common side effects of hydrochlorothiazide include increased urination, dizziness, and electrolyte imbalances, which refer to changes in the levels of minerals in the blood. Losartan may cause dizziness, fatigue, and nasal congestion. Both medicines can lead to low blood pressure, which is a significant adverse effect. Rarely, losartan can cause kidney problems or high potassium levels, while hydrochlorothiazide can lead to dehydration. Monitoring for these side effects is important.
Important safety warnings and contraindications of hydrochlorothiazide and losartan
Hydrochlorothiazide and losartan should not be used during pregnancy due to potential harm to the fetus. People with severe kidney or liver problems should use them cautiously. Hydrochlorothiazide can cause electrolyte imbalances, so regular monitoring is necessary. Losartan can lead to high potassium levels, so potassium intake should be monitored. Both medications can cause low blood pressure, especially when combined with other blood pressure-lowering drugs. Inform healthcare providers of any existing health conditions.

Indications and Purpose

How does combination of hydrochlorothiazide and losartan work?

Hydrochlorothiazide and losartan work together to lower blood pressure. Hydrochlorothiazide is a diuretic, which means it helps the body get rid of excess salt and water through urine, reducing fluid buildup and lowering blood pressure. Losartan is an angiotensin receptor blocker, which means it relaxes blood vessels by blocking a substance that causes them to tighten. This helps blood flow more easily and lowers blood pressure. Together, they provide a more comprehensive approach to managing high blood pressure by addressing both fluid retention and blood vessel constriction.

How does combination of Hydrochlorothiazide and Losartan work?

Hydrochlorothiazide works by acting as a diuretic, helping the kidneys eliminate excess water and salt from the body, which reduces blood volume and lowers blood pressure. Losartan, on the other hand, is an angiotensin II receptor antagonist that blocks the action of substances that tighten blood vessels, allowing them to relax and improve blood flow, thereby reducing blood pressure. Together, they provide a dual approach to managing hypertension by addressing both fluid retention and vascular resistance, leading to more effective blood pressure control.

How effective is combination of hydrochlorothiazide and losartan?

Evidence for the effectiveness of hydrochlorothiazide and losartan comes from clinical studies showing their ability to lower blood pressure. Hydrochlorothiazide, as a diuretic, has been proven to reduce fluid retention and lower blood pressure by increasing urine output. Losartan, as an angiotensin receptor blocker, has been shown to relax blood vessels and lower blood pressure. When used together, studies indicate that they provide a more significant reduction in blood pressure than when used alone. This combination is effective in managing hypertension, which refers to high blood pressure, and reducing the risk of related complications.

How effective is combination of Hydrochlorothiazide and Losartan?

The effectiveness of hydrochlorothiazide and losartan in treating high blood pressure is supported by clinical trials and studies. Hydrochlorothiazide has been shown to effectively reduce blood pressure by decreasing fluid volume, while losartan has demonstrated its ability to lower blood pressure by relaxing blood vessels. Together, they provide a complementary approach, with hydrochlorothiazide addressing fluid retention and losartan improving vascular resistance. Studies have also shown losartan's effectiveness in reducing the risk of stroke and managing kidney disease in diabetic patients, further supporting its role in comprehensive cardiovascular care.

Directions for Use

What is the usual dose of combination of hydrochlorothiazide and losartan?

The usual adult daily dose for hydrochlorothiazide is typically 12.5 to 25 milligrams, taken once a day. For losartan, the usual starting dose is 50 milligrams once a day, which may be adjusted based on the individual's response and needs. When combined, the doses may vary depending on the specific formulation prescribed by a healthcare provider. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare professional. This ensures the medications work effectively and safely to manage blood pressure.

What is the usual dose of combination of Hydrochlorothiazide and Losartan?

The usual adult daily dose for hydrochlorothiazide when used alone is typically 25 mg once daily, but it can vary based on the condition being treated. For losartan, the starting dose is usually 50 mg once daily, which can be adjusted based on the patient's response. When combined in a single tablet, the typical starting dose is 50 mg of losartan and 12.5 mg of hydrochlorothiazide once daily. This combination can be adjusted to a maximum of 100 mg of losartan and 25 mg of hydrochlorothiazide daily, depending on the patient's needs and response to treatment.

How does one take combination of hydrochlorothiazide and losartan?

Hydrochlorothiazide and losartan can be taken with or without food, but it's important to take them consistently at the same time each day. Drinking plenty of water is recommended to prevent dehydration, especially with hydrochlorothiazide. Avoid excessive salt intake, as it can counteract the effects of these medications. It's also advisable to limit alcohol consumption, as it can increase the risk of side effects like dizziness. Always follow the healthcare provider's instructions and discuss any dietary concerns with them.

How does one take combination of Hydrochlorothiazide and Losartan?

Hydrochlorothiazide and losartan can be taken with or without food, but it's important to take them consistently at the same time each day to maintain stable blood levels. Patients should avoid using salt substitutes containing potassium without consulting their doctor, as losartan can increase potassium levels. It's also advisable to follow any dietary recommendations provided by a healthcare provider, such as a low-salt diet, to enhance the effectiveness of the treatment. Staying hydrated is important, especially when taking hydrochlorothiazide, to prevent dehydration.

For how long is combination of hydrochlorothiazide and losartan taken?

Hydrochlorothiazide and losartan are typically used for long-term management of high blood pressure. The duration of use depends on the individual's condition and response to treatment. Some people may need to take these medications indefinitely to maintain blood pressure control and reduce the risk of complications. Regular follow-up with a healthcare provider is important to monitor effectiveness and make any necessary adjustments to the treatment plan. It's crucial not to stop taking these medications without consulting a healthcare professional.

For how long is combination of Hydrochlorothiazide and Losartan taken?

Hydrochlorothiazide and losartan are typically used as long-term treatments for managing high blood pressure. While hydrochlorothiazide can be used for short-term relief of fluid retention, its role in hypertension management is ongoing. Losartan is also used for long-term control of blood pressure and may take several weeks to achieve its full effect. Both medications are usually continued indefinitely to maintain blood pressure control and prevent complications unless otherwise directed by a healthcare provider.

How long does it take for combination of hydrochlorothiazide and losartan to work?

Hydrochlorothiazide, which is a diuretic that helps remove excess fluid from the body, usually starts working within a few hours of taking it. Losartan, which is an angiotensin receptor blocker that helps relax blood vessels, may take a few weeks to show its full effect on blood pressure. When combined, the initial diuretic effect of hydrochlorothiazide can be felt relatively quickly, while the blood pressure-lowering effects of losartan may take longer to become noticeable. Together, they work to manage blood pressure effectively over time.

How long does it take for combination of Hydrochlorothiazide and Losartan to work?

Hydrochlorothiazide and losartan both work to lower blood pressure, but they do so in different ways. Hydrochlorothiazide, a diuretic, helps reduce fluid retention and starts working within a few hours, with its effects lasting about 6 to 12 hours. Losartan, an angiotensin II receptor antagonist, may take a week to start lowering blood pressure, with full effects seen in 3 to 6 weeks. When combined, these medicines can provide a more comprehensive approach to managing high blood pressure, with hydrochlorothiazide offering quicker initial relief and losartan providing longer-term control.

Warnings and Precautions

Are there harms and risks from taking combination of hydrochlorothiazide and losartan?

Common side effects of hydrochlorothiazide include increased urination, dizziness, and electrolyte imbalances, which refer to changes in the levels of minerals in the blood. Losartan may cause dizziness, fatigue, and nasal congestion. Both medicines can lead to low blood pressure, which is a significant adverse effect. Rarely, losartan can cause kidney problems or high potassium levels, while hydrochlorothiazide can lead to dehydration. It's important to monitor for these side effects and consult a healthcare provider if they occur. Together, they effectively manage blood pressure but require monitoring for these potential side effects.

Are there harms and risks from taking combination of Hydrochlorothiazide and Losartan?

Common side effects of hydrochlorothiazide include frequent urination, dizziness, and electrolyte imbalances, such as low potassium levels. Losartan may cause dizziness, back pain, and muscle cramps. Both medications can lead to low blood pressure, especially when standing up quickly. Significant adverse effects include severe allergic reactions, kidney problems, and changes in vision. It's important to monitor for signs of dehydration and electrolyte imbalance, as these can be serious. Patients should report any unusual symptoms to their healthcare provider promptly.

Can I take combination of hydrochlorothiazide and losartan with other prescription drugs?

Hydrochlorothiazide and losartan can interact with several prescription drugs. Combining them with other blood pressure medications can lead to excessively low blood pressure. NSAIDs, which are pain relievers, can reduce the effectiveness of losartan. Diuretics and potassium-sparing diuretics can increase the risk of electrolyte imbalances. Certain cholesterol-lowering drugs can affect how these medications work. It's important to regularly monitor blood pressure and kidney function and to inform healthcare providers of all medications being taken to manage these interactions effectively.

Can I take combination of Hydrochlorothiazide and Losartan with other prescription drugs?

Hydrochlorothiazide and losartan can interact with several prescription medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of both medications in lowering blood pressure. Combining losartan with other drugs that increase potassium levels, such as certain diuretics or ACE inhibitors, can lead to hyperkalemia. Hydrochlorothiazide can interact with lithium, increasing the risk of lithium toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively and adjust dosages as needed.

Can I take combination of hydrochlorothiazide and losartan if I am pregnant?

Hydrochlorothiazide and losartan are generally not recommended during pregnancy. Losartan, in particular, can harm the developing fetus, especially in the second and third trimesters, by affecting kidney development and function. Hydrochlorothiazide may also pose risks, such as affecting the fluid balance in the mother and fetus. If a woman becomes pregnant while taking these medications, it's crucial to consult a healthcare provider immediately. Alternative treatments for managing blood pressure during pregnancy should be considered to ensure the safety of both the mother and the baby.

Can I take combination of Hydrochlorothiazide and Losartan if I am pregnant?

Losartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including kidney damage and death. Hydrochlorothiazide is generally not recommended during pregnancy as it can affect fetal development and lead to complications such as electrolyte imbalances. Pregnant women or those planning to become pregnant should discuss alternative treatments with their healthcare provider to manage their blood pressure safely. It's crucial to discontinue these medications immediately if pregnancy is detected and seek medical advice.

Can I take combination of hydrochlorothiazide and losartan while breastfeeding?

The safety of hydrochlorothiazide and losartan during breastfeeding is not well established. Hydrochlorothiazide is known to pass into breast milk in small amounts, but its effects on a nursing infant are not fully understood. Losartan's safety during breastfeeding is also unclear, and it is generally advised to avoid it due to potential risks to the infant. If treatment with these medications is necessary, a healthcare provider may recommend monitoring the infant for any adverse effects or considering alternative medications that are safer during breastfeeding.

Can I take combination of Hydrochlorothiazide and Losartan while breastfeeding?

Hydrochlorothiazide is known to be excreted in breast milk, and while it is generally considered safe in low doses, it can potentially reduce milk production due to its diuretic effect. Losartan's safety during breastfeeding is less clear, as there is limited information on its excretion in human milk. Due to potential risks to the nursing infant, healthcare providers may recommend alternative treatments or advise against breastfeeding while taking these medications. It's important for breastfeeding mothers to discuss their treatment options with their healthcare provider to ensure the safety of their infant.

Who should avoid taking combination of hydrochlorothiazide and losartan?

Hydrochlorothiazide and losartan have important warnings and contraindications. They should not be used during pregnancy due to potential harm to the fetus. People with severe kidney or liver problems should use them cautiously. Hydrochlorothiazide can cause electrolyte imbalances, so regular monitoring is necessary. Losartan can lead to high potassium levels, so potassium intake should be monitored. Both medications can cause low blood pressure, especially when combined with other blood pressure-lowering drugs. It's crucial to inform healthcare providers of any existing health conditions and medications to avoid complications.

Who should avoid taking combination of Hydrochlorothiazide and Losartan?

Hydrochlorothiazide and losartan have important warnings and contraindications. Both should be used cautiously in patients with kidney or liver disease. Losartan is contraindicated during pregnancy due to the risk of fetal harm. Hydrochlorothiazide can cause electrolyte imbalances, so monitoring is essential. Patients with a history of angioedema should avoid losartan. Both medications can cause dizziness, especially when standing up quickly, so patients should rise slowly from sitting or lying positions. Regular monitoring and communication with a healthcare provider are crucial to manage these risks effectively.