Diphenhydramine + Ibuprofen
Find more information about this combination medication at the webpages for Diphenhydramine and Ibuprofen
Pain, Sleepiness
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Diphenhydramine is used for relieving allergy symptoms, preventing motion sickness, and treating insomnia. Ibuprofen is used for relieving pain, reducing inflammation, and lowering fever. When used together, they can help with sleep when pain is a contributing factor.
Diphenhydramine works by blocking histamine, a substance in the body that causes allergic symptoms. It also has sedative properties that help with sleep. Ibuprofen works by inhibiting substances in the body that cause inflammation, pain, and fever.
For adults, the usual dose of Diphenhydramine is 25-50 mg every 4-6 hours, not exceeding 300 mg per day. Ibuprofen's typical dose is 200-400 mg every 4-6 hours, with a maximum of 1200 mg per day for over-the-counter use. When combined, the typical dose is 25 mg of Diphenhydramine and 200 mg of Ibuprofen, usually taken at bedtime.
Common side effects of Diphenhydramine include drowsiness, dry mouth, dizziness, and nausea. Ibuprofen may cause stomach upset, constipation, and dizziness. When combined, they may increase the risk of drowsiness and gastrointestinal issues.
Diphenhydramine should be avoided in children under 4 years and used with caution in older adults. Ibuprofen carries warnings about increased risk of heart attack, stroke, and stomach bleeding, especially with long-term use. Both should be used cautiously in people with certain health conditions like asthma, liver or kidney disease.
Indications and Purpose
How does combination of Diphenhydramine and Ibuprofen work?
Diphenhydramine works by blocking the action of histamine, a substance in the body that causes allergic symptoms, and it also has sedative properties that help with sleep. Ibuprofen works by inhibiting the production of prostaglandins, substances in the body that cause inflammation, pain, and fever. Together, they provide relief from pain and help with sleep when pain is a contributing factor to sleeplessness, offering a dual action of symptom relief and sedation.
How effective is combination of Diphenhydramine and Ibuprofen?
Diphenhydramine's effectiveness is supported by its long-standing use as an antihistamine for allergy relief and as a sedative for sleep aid. Clinical studies have shown its ability to reduce allergy symptoms and improve sleep quality. Ibuprofen's efficacy is well-documented in reducing pain, inflammation, and fever, with numerous studies supporting its use for conditions like arthritis and minor injuries. Together, they provide a complementary effect, with diphenhydramine aiding sleep and ibuprofen addressing pain, making them effective for conditions where pain disrupts sleep.
Directions for Use
What is the usual dose of combination of Diphenhydramine and Ibuprofen?
For adults, the usual dose of diphenhydramine is 25 mg to 50 mg every 4 to 6 hours, not exceeding 300 mg per day. For ibuprofen, the typical dose is 200 mg to 400 mg every 4 to 6 hours, with a maximum of 1200 mg per day for over-the-counter use. When combined, the typical dose is 25 mg of diphenhydramine and 200 mg of ibuprofen, usually taken at bedtime to address pain and aid sleep. It's important not to exceed the recommended doses to avoid side effects.
How does one take combination of Diphenhydramine and Ibuprofen?
Diphenhydramine and ibuprofen can be taken with or without food, but taking them with food or milk can help prevent stomach upset, especially with ibuprofen. There are no specific food restrictions, but it's important to avoid alcohol as it can increase the sedative effects of diphenhydramine and the risk of stomach bleeding with ibuprofen. Always follow the dosage instructions on the label or as prescribed by a healthcare provider.
For how long is combination of Diphenhydramine and Ibuprofen taken?
Diphenhydramine and ibuprofen are typically used for short-term relief. Diphenhydramine is often used as needed for allergy symptoms or sleep issues, while ibuprofen is used for temporary relief of pain and inflammation. The combination is generally not recommended for long-term use due to potential side effects, such as drowsiness from diphenhydramine and gastrointestinal issues from ibuprofen. It's important to follow the recommended duration of use and consult a healthcare provider if symptoms persist.
How long does it take for combination of Diphenhydramine and Ibuprofen to work?
Diphenhydramine and ibuprofen combination medicine typically starts working within 30 minutes to an hour. Diphenhydramine, an antihistamine, begins to relieve symptoms like sneezing, runny nose, and itching relatively quickly, often within 30 minutes. It also helps with sleep induction due to its sedative properties. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), starts to reduce pain and inflammation within an hour. Both medicines work together to provide relief from pain and help with sleep when pain is a contributing factor to sleeplessness.
Warnings and Precautions
Are there harms and risks from taking combination of Diphenhydramine and Ibuprofen?
Common side effects of diphenhydramine include drowsiness, dry mouth, dizziness, and nausea. Ibuprofen may cause stomach upset, constipation, and dizziness. Significant adverse effects of diphenhydramine can include vision problems and difficulty urinating, while ibuprofen can cause stomach bleeding, heart attack, or stroke, especially with long-term use. Both medications can cause allergic reactions, and combining them may increase the risk of drowsiness and gastrointestinal issues. It's important to use them as directed and consult a healthcare provider if severe side effects occur.
Can I take combination of Diphenhydramine and Ibuprofen with other prescription drugs?
Diphenhydramine can interact with other sedatives, increasing drowsiness, while ibuprofen can interact with anticoagulants, increasing bleeding risk. Both can interact with other antihistamines or NSAIDs, leading to increased side effects. Ibuprofen may also interact with SSRIs, increasing the risk of bleeding. It's crucial to inform your healthcare provider about all medications you are taking to manage these interactions effectively and avoid adverse effects.
Can I take combination of Diphenhydramine and Ibuprofen if I am pregnant?
Diphenhydramine is generally considered safe during pregnancy but should be used under medical supervision, especially in the third trimester. Ibuprofen is not recommended during pregnancy, particularly after 20 weeks, due to risks of complications such as affecting fetal development and delivery issues. Pregnant women should consult their healthcare provider before using these medications to ensure safety for both mother and baby.
Can I take combination of Diphenhydramine and Ibuprofen while breastfeeding?
Diphenhydramine is generally not recommended during breastfeeding as it can pass into breast milk and may cause drowsiness in the nursing infant. Ibuprofen is considered safer during breastfeeding as it passes into breast milk in very low levels and is unlikely to harm the infant. However, it's important for breastfeeding mothers to consult with a healthcare provider before using these medications to weigh the benefits and potential risks.
Who should avoid taking combination of Diphenhydramine and Ibuprofen?
Important warnings for diphenhydramine include avoiding use in children under 4 years and caution in older adults due to increased risk of side effects like drowsiness. Ibuprofen carries warnings about increased risk of heart attack, stroke, and stomach bleeding, especially with long-term use. Both should be used cautiously in people with certain health conditions like asthma, liver or kidney disease, and those who consume alcohol regularly. It's crucial to follow dosing instructions and consult a healthcare provider if you have any pre-existing conditions or are taking other medications.
