Diphenhydramine
Perennial Allergic Rhinitis, Nausea ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Histamine-1 Receptor Antagonist
Controlled Drug Substance
No
Diphenhydramine
Summary
Diphenhydramine is used to relieve symptoms of allergies, which include sneezing and itching, and hay fever, which is an allergic reaction to pollen. It also helps with the common cold, which is a viral infection causing runny nose and sneezing. Additionally, it serves as a sleep aid and prevents motion sickness, which is nausea and dizziness during travel.
Diphenhydramine works by blocking histamine, which is a substance in the body that causes allergic symptoms like sneezing and itching. It belongs to a class of medications called antihistamines, which prevent histamine from attaching to its receptors. This reduces allergy symptoms and also has sedative effects, which help with sleep.
For adults, the usual dose of Diphenhydramine is 25 to 50 mg every 4 to 6 hours as needed, not exceeding 300 mg in 24 hours. It can be taken with or without food. For children, the dose is lower and based on weight. Always follow your doctor's instructions for safe use.
Common side effects of Diphenhydramine include drowsiness, which is feeling sleepy, dry mouth, which is a lack of saliva, and dizziness, which is feeling lightheaded. These effects are usually mild and temporary. If you experience severe or persistent symptoms, contact your doctor for advice.
Avoid alcohol while taking Diphenhydramine, as it can increase drowsiness. Do not use if allergic to it or its ingredients. It's contraindicated in newborns and premature infants. People with severe asthma, which is a lung condition, or glaucoma, which is increased eye pressure, should avoid it. Consult your doctor before use.
Indications and Purpose
How does Diphenhydramine work?
Diphenhydramine works by blocking histamine, which is a substance in the body that causes allergic symptoms like sneezing and itching. It belongs to a class of medications called antihistamines. Think of it like a shield that prevents histamine from attaching to its receptors, reducing allergy symptoms. Diphenhydramine also has sedative effects, which can help with sleep. These effects make it useful for treating allergies, insomnia, and motion sickness. Always use Diphenhydramine as directed by your doctor for the best results.
Is Diphenhydramine effective?
Diphenhydramine is effective for relieving allergy symptoms, such as sneezing, runny nose, and itching. It works by blocking histamine, which is a substance in the body that causes allergic reactions. Diphenhydramine is also used as a sleep aid due to its sedative effects. Clinical studies support its effectiveness for these uses. However, it may cause drowsiness, so use caution when taking it. Always follow your doctor's instructions and use Diphenhydramine as directed for the best results.
What is Diphenhydramine?
Diphenhydramine is an antihistamine, which is a type of medication that blocks histamine, a substance in the body that causes allergic symptoms. It's used to relieve symptoms of allergy, hay fever, and the common cold, such as sneezing, runny nose, and itching. Diphenhydramine is also used as a sleep aid due to its sedative effects. It can help with motion sickness by preventing nausea and dizziness. Always use Diphenhydramine as directed by your doctor for the best results.
Directions for Use
For how long do I take Diphenhydramine?
Diphenhydramine is usually taken for short-term relief of symptoms like allergies or insomnia. The duration of use depends on your specific condition and your doctor's recommendations. For allergies, you might take it as needed during allergy season. For sleep, it's often used for occasional sleeplessness. Always follow your doctor's instructions on how long to take Diphenhydramine. If you have questions about the duration of use, consult your healthcare provider to ensure safe and effective treatment.
How do I dispose of Diphenhydramine?
To dispose of Diphenhydramine, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable, like used coffee grounds, seal it in a plastic bag, and throw it away. Always keep medications out of reach of children and pets.
How do I take Diphenhydramine?
Take Diphenhydramine as directed by your doctor. It's usually taken every 4 to 6 hours as needed. You can take it with or without food. If you have trouble swallowing pills, you can crush Diphenhydramine tablets. Avoid alcohol while taking this medicine, as it can increase drowsiness. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Never take two doses at once. Always follow your doctor's specific instructions for the best results.
How long does it take for Diphenhydramine to start working?
Diphenhydramine usually starts working within 30 minutes to an hour after you take it. The full effects can be felt within 1 to 2 hours. For allergy symptoms, you should notice relief fairly quickly. If you're using it as a sleep aid, take it about 30 minutes before bedtime. Individual factors, like your metabolism and overall health, can affect how quickly it works. Always take Diphenhydramine as directed by your doctor for the best results.
How should I store Diphenhydramine?
Store Diphenhydramine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, as moisture can affect its effectiveness. If your Diphenhydramine came in packaging that isn't child-resistant, transfer it to a container that children can't easily open. Always store it out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Diphenhydramine?
The usual dose of Diphenhydramine for adults is 25 to 50 mg every 4 to 6 hours as needed. Do not exceed 300 mg in 24 hours. For children, the dose is typically lower and based on their weight. Elderly patients may require a lower dose due to increased sensitivity to the medication. Always follow your doctor's specific dosing instructions. If you have any questions about your dose, consult your healthcare provider to ensure safe and effective use of Diphenhydramine.
Warnings and Precautions
Can Diphenhydramine be taken safely while breastfeeding?
Diphenhydramine is generally considered safe while breastfeeding, but it can pass into breast milk in small amounts. It may cause drowsiness in the breastfed infant. If you need to take Diphenhydramine, use the lowest effective dose and monitor your baby for any side effects, like unusual sleepiness. Talk with your doctor about the risks and benefits of using Diphenhydramine while breastfeeding. They can help determine if it's the best option for you and your baby.
Can Diphenhydramine be taken safely while pregnant?
Diphenhydramine is generally considered safe during pregnancy, but it's important to use it only when necessary and under a doctor's guidance. Limited studies suggest it doesn't cause harm to the baby, but more research is needed. Uncontrolled allergy symptoms can also affect pregnancy, so managing them is important. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your symptoms. They can help create a treatment plan that protects both you and your baby.
Can I take Diphenhydramine with other prescription drugs?
Diphenhydramine can interact with other medications, increasing the risk of side effects. Combining it with other sedatives, like benzodiazepines or opioids, can enhance drowsiness and dizziness. It may also interact with medications for depression or anxiety, affecting their effectiveness. Always inform your doctor about all the medications you take, including over-the-counter drugs and supplements. They can help identify potential interactions and adjust your treatment plan to ensure safety and effectiveness.
Does Diphenhydramine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Diphenhydramine include drowsiness, dry mouth, and dizziness. These effects are usually mild. Serious adverse effects, like difficulty breathing or severe allergic reactions, are rare but require immediate medical attention. If you experience any new or worsening symptoms while taking Diphenhydramine, contact your doctor. They can help determine if the medication is the cause and suggest appropriate actions. Always follow your doctor's instructions to minimize the risk of adverse effects.
Does Diphenhydramine have any safety warnings?
Yes, Diphenhydramine has safety warnings. It can cause drowsiness, which may impair your ability to drive or operate machinery. Avoid alcohol, as it can increase drowsiness. Diphenhydramine may also cause dry mouth, blurred vision, and constipation. In some cases, it can lead to confusion or difficulty urinating, especially in older adults. If you experience any severe side effects, such as difficulty breathing or swelling, seek medical help immediately. Always follow your doctor's instructions and read the medication label for safety information.
Is Diphenhydramine addictive?
Diphenhydramine is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. However, some people may misuse it for its sedative effects, which can lead to tolerance, meaning they need more to achieve the same effect. To avoid misuse, take Diphenhydramine only as directed by your doctor. If you have concerns about dependency, talk with your healthcare provider. They can provide guidance on safe use and address any worries you may have.
Is Diphenhydramine safe for the elderly?
Elderly individuals are more vulnerable to the side effects of Diphenhydramine, such as drowsiness, dizziness, and confusion. These effects can increase the risk of falls and accidents. It's important for older adults to use Diphenhydramine with caution and under a doctor's guidance. Lower doses may be recommended to minimize side effects. If you're an older adult or caring for one, talk with your doctor about the safest way to use Diphenhydramine and manage any symptoms.
Is it safe to drink alcohol while taking Diphenhydramine?
It's best to avoid alcohol while taking Diphenhydramine. Alcohol can increase the sedative effects of Diphenhydramine, leading to increased drowsiness and dizziness. This combination can impair your ability to drive or operate machinery safely. If you do choose to drink, limit your alcohol intake and be aware of how your body responds. Talk with your doctor about alcohol use while taking Diphenhydramine to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Diphenhydramine?
You can exercise while taking Diphenhydramine, but be cautious. This medication can cause drowsiness and dizziness, which might affect your balance and coordination during physical activity. To exercise safely, start with light activities and see how your body responds. Avoid strenuous activities or high-impact sports until you know how Diphenhydramine affects you. If you feel dizzy or lightheaded, stop exercising and rest. Talk with your doctor if you have concerns about exercising while taking this medication.
Is it safe to stop Diphenhydramine?
Yes, it's generally safe to stop Diphenhydramine, as it's used for short-term relief of symptoms like allergies or insomnia. There are no withdrawal symptoms associated with stopping this medication. However, if you're using it regularly for a specific condition, talk with your doctor before stopping. They can provide guidance on managing your symptoms without Diphenhydramine. Always follow your doctor's advice to ensure your health and safety when making changes to your medication routine.
What are the most common side effects of Diphenhydramine?
Side effects are unwanted reactions to a medication. Common side effects of Diphenhydramine include drowsiness, dry mouth, and dizziness. These effects are usually mild and temporary. Some people may also experience blurred vision or constipation. If you notice new symptoms after starting Diphenhydramine, they might be temporary or unrelated to the medication. Talk with your doctor if you have concerns. They can help determine if the side effects are related to Diphenhydramine and suggest ways to manage them.
Who should avoid taking Diphenhydramine?
Do not use Diphenhydramine if you are allergic to it or its ingredients. It's also contraindicated in newborns and premature infants. People with certain conditions, like severe asthma or glaucoma, which is increased pressure in the eye, should avoid it. Use caution if you have conditions like high blood pressure or an enlarged prostate, which can cause urination problems. Always consult your doctor before using Diphenhydramine, especially if you have any medical conditions or are taking other medications.
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