Benazepril + Hydrochlorothiazide
Find more information about this combination medication at the webpages for Benazepril and Hydrochlorothiazide
Hypertension, Left Ventricular Dysfunction ... show more
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Advisory
- This medicine contains a combination of 2 drugs Benazepril and Hydrochlorothiazide.
- Benazepril and Hydrochlorothiazide are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor and Thiazide Diuretic
Controlled Drug Substance
NO
Benazepril + Hydrochlorothiazide
Summary
Benazepril and Hydrochlorothiazide are primarily used to treat high blood pressure, also known as hypertension. By effectively lowering blood pressure, they help reduce the risk of complications such as heart disease, heart attack, stroke, and kidney failure.
Benazepril, an ACE inhibitor, works by reducing the production of a chemical that causes blood vessels to constrict, thereby relaxing the vessels and lowering blood pressure. Hydrochlorothiazide, a diuretic, helps the kidneys remove excess salt and water from the body, reducing blood volume and pressure. Together, they manage hypertension effectively.
The usual adult daily dose for Benazepril and Hydrochlorothiazide varies depending on the specific needs of the patient. Typically, the combination tablets are available in doses of 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg of Benazepril and Hydrochlorothiazide respectively. The starting dose is often 10 mg/12.5 mg once daily.
Common side effects include cough, dizziness, excessive tiredness, and drowsiness. Serious adverse effects can include swelling of the face or throat, difficulty breathing, rash, and lightheadedness. Hydrochlorothiazide may cause electrolyte imbalances, while Benazepril can lead to a potentially life-threatening condition called angioedema.
These medications carry important warnings including the risk of fetal toxicity if taken during pregnancy. They are not recommended for patients with a history of angioedema related to ACE inhibitors and those with severe kidney impairment. Patients should be cautious of potential low blood pressure, especially if dehydrated or on other blood pressure medications. Regular monitoring of blood pressure and kidney function is advised.
Indications and Purpose
How does combination of Benazepril and Hydrochlorothiazide work?
The combination of Benazepril and Hydrochlorothiazide is used to treat high blood pressure. Benazepril is an ACE inhibitor, which means it helps relax blood vessels by blocking a substance in the body that causes them to tighten. This makes it easier for the heart to pump blood. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps the body get rid of excess salt and water through urine. This reduces the volume of fluid in the blood vessels, further lowering blood pressure. Together, these medications help to effectively manage blood pressure and reduce the risk of complications such as heart attacks and strokes.
How does combination of Hydrochlorothiazide and Benazepril work?
Hydrochlorothiazide and benazepril work together to lower blood pressure through complementary mechanisms. Benazepril, an ACE inhibitor, reduces the production of angiotensin II, a chemical that causes blood vessels to constrict, thereby relaxing the vessels and lowering blood pressure. Hydrochlorothiazide, a diuretic, helps the kidneys remove excess salt and water from the body, reducing blood volume and pressure. Together, they effectively manage hypertension by addressing both vascular resistance and fluid retention.
How effective is combination of Benazepril and Hydrochlorothiazide?
The combination of Benazepril and Hydrochlorothiazide is used to treat high blood pressure (hypertension). Benazepril is an ACE inhibitor, which helps relax blood vessels, making it easier for the heart to pump blood. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps the body get rid of excess salt and water through urine. Together, these medications work effectively to lower blood pressure more than either drug alone, reducing the risk of stroke and heart attack. According to the NHS and NLM, this combination is generally effective for many patients, but its effectiveness can vary based on individual health conditions and response to treatment. It's important to follow a healthcare provider's guidance when using these medications.
How effective is combination of Hydrochlorothiazide and Benazepril?
Clinical studies have demonstrated that the combination of hydrochlorothiazide and benazepril effectively lowers blood pressure in patients with hypertension. Benazepril, as an ACE inhibitor, has been shown to reduce blood vessel constriction, while hydrochlorothiazide, a diuretic, decreases fluid volume by promoting urine production. Together, they provide a synergistic effect, enhancing blood pressure control. The combination has been tested in various clinical trials, showing significant reductions in both systolic and diastolic blood pressure, confirming its efficacy in managing hypertension.
Directions for Use
What is the usual dose of combination of Benazepril and Hydrochlorothiazide?
The usual dose of the combination of Benazepril and Hydrochlorothiazide can vary based on individual health needs, but typically, it starts at a low dose and may be adjusted by a healthcare provider. According to the NHS and DailyMeds, a common starting dose is 10 mg of Benazepril combined with 12.5 mg of Hydrochlorothiazide once daily. However, the exact dose should be determined by a healthcare professional, who will consider factors like your blood pressure levels and any other health conditions you may have. Benazepril is an ACE inhibitor that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps reduce fluid retention.
What is the usual dose of combination of Hydrochlorothiazide and Benazepril?
The usual adult daily dose for the combination of hydrochlorothiazide and benazepril varies depending on the specific formulation and patient needs. Typically, the combination tablets are available in doses of 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg of benazepril and hydrochlorothiazide, respectively. The starting dose is often 10 mg/12.5 mg once daily, which can be adjusted based on the patient's response and blood pressure goals. Both medicines work together to manage high blood pressure, with benazepril reducing blood vessel constriction and hydrochlorothiazide promoting the excretion of excess fluid.
How does one take combination of Benazepril and Hydrochlorothiazide?
Benazepril and Hydrochlorothiazide are medications often combined to treat high blood pressure. Benazepril is an ACE inhibitor that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps remove excess fluid from the body. When taking this combination, it is usually administered orally in tablet form. It is important to follow the dosage instructions provided by your healthcare provider, which typically involves taking the medication once daily, with or without food. Consistency in taking the medication at the same time each day can help maintain its effectiveness. Before starting this medication, inform your doctor about any other medications you are taking and any medical conditions you have, as this can affect how you should take the combination. Regular monitoring of blood pressure and kidney function may be necessary to ensure the medication is working effectively and safely. For more detailed information, you can refer to trusted sources like the NHS, DailyMeds, or the National Library of Medicine (NLM).
How does one take combination of Hydrochlorothiazide and Benazepril?
Hydrochlorothiazide and benazepril can be taken with or without food, but it is important to take the medication at the same time each day to maintain consistent blood levels. Patients should follow any dietary recommendations provided by their healthcare provider, such as a low-salt diet, to enhance the medication's effectiveness. It's also advised to avoid potassium supplements or salt substitutes containing potassium unless directed by a doctor, as these can interact with the medication.
For how long is combination of Benazepril and Hydrochlorothiazide taken?
The combination of Benazepril and Hydrochlorothiazide is typically taken as a long-term treatment for high blood pressure. The duration of treatment can vary depending on individual health needs and how well the medication is controlling blood pressure. It's important to follow your healthcare provider's instructions and have regular check-ups to determine the appropriate length of treatment. Always consult with your doctor before making any changes to your medication regimen.
For how long is combination of Hydrochlorothiazide and Benazepril taken?
Hydrochlorothiazide and benazepril are typically used as long-term treatments for managing high blood pressure. While they help control blood pressure, they do not cure hypertension, so continuous use is often necessary to maintain the desired blood pressure levels. Patients should follow their doctor's instructions and not stop taking the medication without consulting their healthcare provider, even if they feel well.
How long does it take for combination of Benazepril and Hydrochlorothiazide to work?
The combination of Benazepril and Hydrochlorothiazide typically starts to work within a few hours after taking it. However, it may take several weeks to experience the full benefits in terms of lowering blood pressure. Benazepril is an ACE inhibitor that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps reduce excess fluid in the body. Together, they help lower blood pressure more effectively.
How long does it take for combination of Hydrochlorothiazide and Benazepril to work?
The combination of hydrochlorothiazide and benazepril typically starts working within 1 to 2 hours after ingestion. Benazepril, an ACE inhibitor, begins to lower blood pressure within 1 hour, with peak effects occurring 2 to 4 hours after dosing. Hydrochlorothiazide, a diuretic, starts to increase urine production within 2 hours, peaking around 4 hours. Both medicines work together to effectively reduce blood pressure, with benazepril relaxing blood vessels and hydrochlorothiazide helping the body eliminate excess salt and water.
Warnings and Precautions
Are there harms and risks from taking combination of Benazepril and Hydrochlorothiazide?
Yes, there are potential harms and risks from taking a combination of Benazepril and Hydrochlorothiazide. Benazepril is a medication that helps lower blood pressure by relaxing blood vessels, while Hydrochlorothiazide is a diuretic that helps the body get rid of excess salt and water. According to the NHS and NLM, some common side effects of this combination can include dizziness, lightheadedness, or dehydration, especially when you first start taking it or if your dose is increased. This is because both medications can lower blood pressure, which might cause these symptoms. More serious risks include kidney problems, as both medications can affect kidney function. It's important to have regular blood tests to monitor kidney function and electrolyte levels, as Hydrochlorothiazide can cause imbalances in minerals like potassium and sodium. Additionally, there is a risk of an allergic reaction, which could manifest as swelling, rash, or difficulty breathing. If you experience these symptoms, you should seek medical attention immediately. It's crucial to follow your healthcare provider's instructions and report any unusual symptoms or side effects you experience while taking these medications.
Are there harms and risks from taking combination of Hydrochlorothiazide and Benazepril?
Common side effects of hydrochlorothiazide and benazepril include cough, dizziness, excessive tiredness, and drowsiness. Serious adverse effects can include swelling of the face or throat, difficulty breathing, rash, and lightheadedness. Hydrochlorothiazide may cause electrolyte imbalances, while benazepril can lead to angioedema, a potentially life-threatening condition. Patients should report any severe or persistent symptoms to their healthcare provider immediately. Both medications can cause a drop in blood pressure, leading to fainting or weakness, especially if the patient is dehydrated.
Can I take combination of Benazepril and Hydrochlorothiazide with other prescription drugs?
When taking a combination of Benazepril and Hydrochlorothiazide, it's important to be cautious about interactions with other prescription drugs. Benazepril is an ACE inhibitor, which helps relax blood vessels, and Hydrochlorothiazide is a diuretic, which helps reduce fluid retention. According to the NHS, combining these medications with other drugs can sometimes lead to interactions. For example, taking them with other blood pressure medications can increase the risk of low blood pressure. Additionally, combining them with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce their effectiveness and potentially harm the kidneys. The NLM advises that you should always inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid harmful interactions. They can provide guidance on safe combinations and adjust dosages if necessary. For more detailed information, you can refer to resources like DailyMeds, which provide comprehensive drug interaction details.
Can I take combination of Hydrochlorothiazide and Benazepril with other prescription drugs?
Significant drug interactions with hydrochlorothiazide and benazepril include nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, which can reduce the effectiveness of the blood pressure medication. Combining these drugs with other blood pressure medications or diuretics can enhance their effects, potentially leading to low blood pressure. Additionally, using this combination with lithium can increase the risk of lithium toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of Benazepril and Hydrochlorothiazide if I am pregnant?
It is not recommended to take Benazepril and Hydrochlorothiazide during pregnancy. Benazepril is an ACE inhibitor, which can harm the developing baby, especially in the second and third trimesters. Hydrochlorothiazide is a diuretic, and while it is sometimes used during pregnancy, it should only be taken if clearly needed and prescribed by a healthcare provider. Always consult your doctor for advice specific to your health situation.
Can I take combination of Hydrochlorothiazide and Benazepril if I am pregnant?
Hydrochlorothiazide and benazepril are not recommended during pregnancy due to the risk of fetal toxicity. These medications can harm the developing fetus, particularly during the second and third trimesters, leading to complications such as kidney damage and developmental issues. If pregnancy is detected, the medication should be discontinued immediately, and alternative treatments should be considered. It's crucial for women of childbearing age to discuss potential risks with their healthcare provider before starting this medication.
Can I take combination of Benazepril and Hydrochlorothiazide while breastfeeding?
According to the NHS, it is important to consult with a healthcare professional before taking any medication while breastfeeding. Benazepril is an ACE inhibitor used to treat high blood pressure, and Hydrochlorothiazide is a diuretic that helps reduce fluid retention. Both medications can pass into breast milk, but the effects on a nursing infant are not well-studied. The NLM suggests that the benefits and risks should be carefully weighed, and alternative medications may be considered. Always discuss with your doctor to ensure the safety of your baby.
Can I take combination of Hydrochlorothiazide and Benazepril while breastfeeding?
During lactation, hydrochlorothiazide is known to be excreted in breast milk, and while benazepril is present in minimal amounts, the potential for adverse effects on the nursing infant exists. Due to the risk of serious reactions in infants, a decision should be made to either discontinue breastfeeding or discontinue the medication, considering the importance of the drug to the mother. It's essential to consult a healthcare provider to weigh the benefits and risks before using this medication while breastfeeding.
Who should avoid taking combination of Benazepril and Hydrochlorothiazide?
People who should avoid taking the combination of Benazepril and Hydrochlorothiazide include those who are allergic to either of these medications or any of their components. Additionally, individuals with a history of angioedema (swelling under the skin) related to previous ACE inhibitor use, such as Benazepril, should avoid this combination. Pregnant women should not take this combination due to the risk of harm to the unborn baby. People with severe kidney disease or those unable to urinate should also avoid it. It's important to consult a healthcare provider for personalized advice, especially if you have other health conditions or are taking other medications.
Who should avoid taking combination of Hydrochlorothiazide and Benazepril?
Hydrochlorothiazide and benazepril carry important warnings, including the risk of fetal toxicity if taken during pregnancy, which can harm the developing fetus. They are contraindicated in patients with a history of angioedema related to ACE inhibitors, and those with severe kidney impairment. Patients should be cautious of potential hypotension, especially if dehydrated or on other blood pressure medications. It's crucial to inform healthcare providers of any allergies, as hypersensitivity reactions can occur. Regular monitoring of blood pressure and kidney function is advised.
