Aspirin + Dipyridamole
Find more information about this combination medication at the webpages for dipyridamole and aspirin
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Advisory
- This medicine contains a combination of 2 active drug ingredients aspirin and dipyridamole.
- Both drugs treat the same disease or symptom and work in similar ways.
- Taking two drugs that work in the same way usually has no advantage over one of the drugs at the right dose.
- Most doctors do not prescribe multiple drugs that work in the same ways.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug and Platelet Aggregation Inhibitor
Controlled Drug Substance
NO
aspirin + dipyridamole
Summary
Aspirin and dipyridamole are used to prevent strokes, which are brain injuries caused by interrupted blood flow, in people who have had transient ischemic attacks, which are brief strokes. They also help reduce the risk of heart attacks, which occur when blood flow to the heart is blocked, and other cardiovascular events, which are problems related to the heart and blood vessels.
Aspirin works by stopping platelets, which are small blood cells, from clumping together, reducing blood clots. Dipyridamole helps widen blood vessels, which are tubes that carry blood, and prevents platelets from sticking together. Together, they enhance each other's effects, providing a comprehensive approach to preventing blood clots and reducing the risk of stroke and other cardiovascular events.
The usual adult dose for aspirin when used with dipyridamole is 25 mg of aspirin and 200 mg of dipyridamole, taken twice daily. This combination is designed to provide the benefits of both medications while minimizing side effects. It's important to follow the prescribed dosage and not adjust the dose without consulting a healthcare provider.
Common side effects of aspirin include stomach upset and increased bleeding risk. Dipyridamole may cause headaches and dizziness. Both medicines can lead to gastrointestinal issues, such as nausea or indigestion. Significant adverse effects include the risk of bleeding, especially in the stomach or brain, due to aspirin's blood-thinning properties. Monitoring for these side effects is crucial.
Aspirin and dipyridamole should not be used by individuals with bleeding disorders, such as hemophilia, or active ulcers due to increased bleeding risk. Aspirin is contraindicated in children with viral infections due to Reye's syndrome, which is a serious condition. Pregnant women should avoid aspirin, especially in the third trimester, due to risks like bleeding and delayed labor.
Indications and Purpose
How does combination of aspirin and dipyridamole work?
Aspirin works by inhibiting an enzyme called cyclooxygenase, which reduces the production of substances that cause pain and inflammation, and prevents platelets from clumping together, reducing the risk of blood clots. Dipyridamole works by inhibiting the uptake of adenosine, which is a chemical that helps widen blood vessels and further prevents platelet aggregation. Together, they enhance each other's effects, providing a comprehensive approach to preventing blood clots and reducing the risk of stroke and other cardiovascular events.
How does combination of Aspirin and Dipyridamole work?
Aspirin and dipyridamole work together to prevent blood clots by inhibiting platelet aggregation. Aspirin achieves this by irreversibly inhibiting the enzyme cyclooxygenase, which reduces the production of thromboxane A2, a molecule that promotes platelet aggregation. Dipyridamole complements this action by inhibiting the uptake of adenosine into platelets, leading to increased levels of cyclic AMP, which further inhibits platelet function. This dual mechanism provides a comprehensive approach to reducing the risk of stroke.
How effective is combination of aspirin and dipyridamole?
Studies have shown that aspirin and dipyridamole together significantly reduce the risk of stroke in patients with a history of transient ischemic attacks, which are brief strokes. Aspirin's effectiveness is well-documented in preventing heart attacks by reducing platelet aggregation, while dipyridamole enhances this effect by inhibiting platelet function and dilating blood vessels. Clinical trials have demonstrated that the combination is more effective than either drug alone in preventing recurrent strokes, providing a comprehensive approach to managing cardiovascular risks.
How effective is combination of Aspirin and Dipyridamole?
The effectiveness of aspirin and dipyridamole in reducing the risk of stroke has been demonstrated in clinical trials such as the European Stroke Prevention Study-2 (ESPS2). This study showed that the combination reduced the risk of stroke by 36.8% compared to placebo, and by 22.1% compared to aspirin alone. Aspirin provides immediate antiplatelet effects, while dipyridamole offers sustained action through its extended-release formulation, together providing a comprehensive approach to stroke prevention.
Directions for Use
What is the usual dose of combination of aspirin and dipyridamole?
The usual adult dose for aspirin when used in combination with dipyridamole is typically 25 mg of aspirin and 200 mg of dipyridamole, taken twice daily. This combination is designed to provide the benefits of both medications while minimizing the risk of side effects. It's important to follow the prescribed dosage and not to adjust the dose without consulting a healthcare provider. This ensures the treatment is both safe and effective in preventing strokes and other cardiovascular events.
What is the usual dose of combination of Aspirin and Dipyridamole?
The usual adult daily dose for the combination of aspirin and dipyridamole is one capsule taken twice daily, once in the morning and once in the evening. Each capsule contains 25 mg of aspirin and 200 mg of extended-release dipyridamole. This dosing regimen ensures that the antiplatelet effects of both medicines are maintained throughout the day, with aspirin providing immediate platelet inhibition and dipyridamole offering prolonged action due to its extended-release formulation.
How does one take combination of aspirin and dipyridamole?
Aspirin and dipyridamole should be taken with food to minimize stomach upset. It's important to take the medication at the same time each day to maintain consistent levels in the body. Patients should avoid alcohol, as it can increase the risk of stomach bleeding. Additionally, they should inform their healthcare provider of any dietary supplements or herbal products they are using, as these can interact with the medication. Following these instructions helps ensure the safe and effective use of the combination therapy.
How does one take combination of Aspirin and Dipyridamole?
Aspirin and dipyridamole capsules should be taken twice daily, once in the morning and once in the evening, and can be taken with or without food. The capsules should be swallowed whole and not crushed or chewed. There are no specific food restrictions, but patients should be cautious with alcohol consumption, as it can increase the risk of bleeding. It's important to follow the prescribed regimen and consult a healthcare provider if there are any concerns.
For how long is combination of aspirin and dipyridamole taken?
The typical duration of use for aspirin and dipyridamole is long-term, often for the rest of a patient's life, especially for those at high risk of stroke or cardiovascular events. This ongoing use helps maintain the protective effects against blood clots. Regular follow-ups with a healthcare provider are necessary to monitor the effectiveness and adjust the treatment as needed. Consistent use is crucial to prevent the recurrence of strokes and other related health issues.
For how long is combination of Aspirin and Dipyridamole taken?
Aspirin and dipyridamole are typically used long-term to reduce the risk of stroke in patients with a history of transient ischemic attacks or ischemic strokes. The duration of use is generally indefinite, as long as the patient continues to be at risk for stroke and can tolerate the medication. Regular follow-ups with a healthcare provider are necessary to monitor the effectiveness and any potential side effects of the treatment.
How long does it take for combination of aspirin and dipyridamole to work?
Aspirin, which is a pain reliever and anti-inflammatory, starts working within 30 minutes to an hour. Dipyridamole, which is a blood thinner, may take a bit longer to show its effects, often requiring a few days to reach its full potential. When combined, the effects of aspirin can be felt relatively quickly, while dipyridamole works in the background to enhance the overall benefit over time. Together, they help prevent blood clots and reduce the risk of stroke.
How long does it take for combination of Aspirin and Dipyridamole to work?
Aspirin and dipyridamole work together to prevent blood clots, which can reduce the risk of stroke. Aspirin acts quickly to inhibit platelet aggregation, with effects starting within 30 minutes to an hour after ingestion. Dipyridamole, on the other hand, has a slower onset as it is an extended-release formulation, reaching peak plasma levels approximately 2 hours after administration. The combination of these two medicines provides a balanced approach to reducing stroke risk, with aspirin providing immediate action and dipyridamole offering sustained effects.
Warnings and Precautions
Are there harms and risks from taking combination of aspirin and dipyridamole?
Common side effects of aspirin include stomach upset and increased bleeding risk, while dipyridamole may cause headaches and dizziness. Both medicines can lead to gastrointestinal issues, such as nausea or indigestion. Significant adverse effects include the risk of bleeding, especially in the stomach or brain, due to aspirin's blood-thinning properties. Dipyridamole can cause low blood pressure, leading to fainting. Monitoring for these side effects is crucial, and any severe symptoms should be reported to a healthcare provider immediately.
Are there harms and risks from taking combination of Aspirin and Dipyridamole?
Common side effects of aspirin and dipyridamole include headache, heartburn, stomach pain, nausea, vomiting, diarrhea, and muscle and joint pain. Significant adverse effects can include bleeding, severe rash, swelling of the lips, tongue, or mouth, difficulty breathing, and chest pain. Patients should be aware of these potential side effects and contact their healthcare provider if they experience any severe or persistent symptoms.
Can I take combination of aspirin and dipyridamole with other prescription drugs?
Aspirin and dipyridamole can interact with anticoagulants like warfarin, increasing the risk of bleeding. They may also interact with certain blood pressure medications, potentially affecting their efficacy. Nonsteroidal anti-inflammatory drugs (NSAIDs) can enhance the gastrointestinal side effects of aspirin. It's crucial for patients to inform their healthcare provider of all prescription medications they are taking to avoid harmful interactions. Regular monitoring and dose adjustments may be necessary to ensure safe and effective treatment.
Can I take combination of Aspirin and Dipyridamole with other prescription drugs?
Aspirin and dipyridamole can interact with several prescription drugs, increasing the risk of bleeding. These include anticoagulants like warfarin and heparin, other antiplatelet agents, and NSAIDs. Additionally, aspirin can affect the efficacy of ACE inhibitors and beta-blockers, while dipyridamole can interact with adenosinergic agents used in stress testing. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Can I take combination of aspirin and dipyridamole if I am pregnant?
Aspirin is generally not recommended during pregnancy, especially in the third trimester, due to the risk of complications such as bleeding and delayed labor. Dipyridamole's safety during pregnancy is not well-established, and it should be used only if clearly needed. Both medicines can potentially affect fetal development, so their use should be carefully considered and monitored by a healthcare provider. Pregnant women should discuss the risks and benefits with their doctor before using these medications.
Can I take combination of Aspirin and Dipyridamole if I am pregnant?
Aspirin and dipyridamole should be used with caution during pregnancy, particularly after 20 weeks, due to the risk of fetal harm and complications during delivery. Aspirin, an NSAID, can cause issues such as prolonged labor and bleeding in the mother and fetus. There is limited data on the effects of dipyridamole during pregnancy, but it is generally advised to use this combination only if the potential benefits justify the risks. Pregnant women should consult their healthcare provider before using this medication.
Can I take combination of aspirin and dipyridamole while breastfeeding?
Aspirin is generally not recommended during breastfeeding due to the risk of Reye's syndrome, which is a rare but serious condition, in infants. Dipyridamole is considered to have a low risk during breastfeeding, but caution is still advised. Both medicines can pass into breast milk, so their use should be discussed with a healthcare provider. If necessary, alternative medications with a better safety profile during lactation may be considered to ensure the well-being of the nursing infant.
Can I take combination of Aspirin and Dipyridamole while breastfeeding?
During lactation, aspirin and dipyridamole can pass into breast milk. While low levels of salicylic acid, a metabolite of aspirin, have been detected in breast milk, the effects on the breastfed infant are not well-documented. Dipyridamole is also present in breast milk, but its impact on the infant is unclear. Breastfeeding mothers should discuss the risks and benefits with their healthcare provider to determine the best course of action.
Who should avoid taking combination of aspirin and dipyridamole?
Aspirin and dipyridamole should not be used by individuals with a history of bleeding disorders, such as hemophilia, or those with active ulcers due to the increased risk of bleeding. People with severe liver or kidney disease should also avoid these medications. Aspirin is contraindicated in children and teenagers with viral infections due to the risk of Reye's syndrome. Patients should be aware of potential allergic reactions and should seek medical advice if they experience symptoms like rash or difficulty breathing.
Who should avoid taking combination of Aspirin and Dipyridamole?
Important warnings for aspirin and dipyridamole include the risk of bleeding, especially in patients taking other anticoagulants or with a history of bleeding disorders. It is contraindicated in individuals with known allergies to NSAIDs, aspirin, or dipyridamole, and in those with asthma, rhinitis, and nasal polyps. Patients with severe liver or kidney dysfunction should avoid this medication. Pregnant women, especially after 20 weeks, should use it only if clearly needed and under medical supervision.
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