Amlodipine + Perindopril
Find more information about this combination medication at the webpages for Perindopril and Amlodipine
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Advisory
- This medicine contains a combination of 2 drugs Amlodipine and Perindopril.
- Amlodipine and Perindopril are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Amlodipine and Perindopril are used to treat high blood pressure, also known as hypertension, and coronary artery disease. Amlodipine is also used to manage angina, a type of chest pain caused by reduced blood flow to the heart. Perindopril is effective in treating heart failure and preventing heart attacks.
Amlodipine works by blocking calcium channels in the muscle of blood vessels, causing them to relax and widen, which lowers blood pressure and reduces chest pain. Perindopril prevents the formation of a chemical that narrows blood vessels, thus improving blood flow and reducing blood pressure.
The usual adult daily dose for Amlodipine is typically 5 mg to 10 mg once daily. For Perindopril, the usual starting dose is 4 mg once daily, which may be increased to 8 mg based on the patient's needs and tolerance. Both medications are taken orally.
Common side effects of Amlodipine include swelling of the hands, feet, or ankles, dizziness, and flushing. Perindopril may cause a persistent cough, dizziness, and headache. Both medications can lead to more serious side effects such as severe allergic reactions, rapid heartbeat, or fainting.
Amlodipine should be used cautiously in patients with severe low blood pressure or heart failure. Perindopril is not recommended during pregnancy due to the risk of harm to the fetus and should not be used in patients with a history of angioedema, a severe allergic reaction. Both medications require caution in patients with kidney or liver impairment.
Indications and Purpose
How does combination of Amlodipine and Perindopril work?
Amlodipine works by blocking calcium channels in the smooth muscle of blood vessels, leading to relaxation and dilation of these vessels, which reduces blood pressure and alleviates angina. Perindopril, on the other hand, inhibits the angiotensin-converting enzyme (ACE), preventing the formation of angiotensin II, a substance that narrows blood vessels. This action also results in vasodilation and reduced blood pressure. Both medications ultimately aim to improve blood flow and reduce the workload on the heart, but they achieve this through different mechanisms.
How effective is combination of Amlodipine and Perindopril?
The effectiveness of Amlodipine and Perindopril is supported by clinical studies and their widespread use in managing cardiovascular conditions. Amlodipine has been shown to effectively lower blood pressure and reduce angina attacks, improving exercise tolerance and quality of life. Perindopril has demonstrated benefits in reducing blood pressure, improving heart function, and decreasing the risk of heart attacks and strokes. Together, they provide a comprehensive approach to cardiovascular health by addressing different pathways, with Amlodipine offering immediate relief and Perindopril contributing to long-term management.
Directions for Use
What is the usual dose of combination of Amlodipine and Perindopril?
The usual adult daily dose for Amlodipine is typically 5 mg to 10 mg once daily, depending on the patient's response and condition. For Perindopril, the usual starting dose is 4 mg once daily, which may be increased to 8 mg based on the patient's needs and tolerance. Both medications are taken orally and are often prescribed together to enhance blood pressure control. The combination allows for a synergistic effect, where Amlodipine provides immediate blood pressure reduction and Perindopril offers sustained control.
How does one take combination of Amlodipine and Perindopril?
Amlodipine can be taken with or without food, while Perindopril is best taken before a meal to enhance absorption. Patients are advised to take these medications at the same time each day to maintain consistent blood levels. It's important to follow any dietary instructions provided by a healthcare provider, such as adhering to a low-salt diet, which can enhance the effectiveness of these medications. Patients should also avoid using salt substitutes containing potassium without consulting their doctor, as these can interact with Perindopril.
For how long is combination of Amlodipine and Perindopril taken?
Amlodipine and Perindopril are typically used as long-term treatments for managing high blood pressure and coronary artery disease. Both medications are intended for continuous use to maintain their therapeutic effects, as they do not cure these conditions but help control them. Patients are advised to continue taking these medications even if they feel well, as stopping them without medical advice can lead to a return of symptoms or worsening of the condition. Regular monitoring by a healthcare provider is essential to ensure the medications are working effectively.
How long does it take for combination of Amlodipine and Perindopril to work?
Amlodipine and Perindopril both work to lower blood pressure, but they do so in different ways. Amlodipine, a calcium channel blocker, typically starts to work within a few hours, with its peak effect occurring within 6 to 12 hours. Perindopril, an ACE inhibitor, also begins to lower blood pressure within a few hours, but its full effect may take several weeks to be realized. When combined, these medications can provide a more comprehensive approach to managing high blood pressure, with Amlodipine offering quicker relief and Perindopril contributing to long-term control.
Warnings and Precautions
Are there harms and risks from taking combination of Amlodipine and Perindopril?
Common side effects of Amlodipine include swelling of the hands, feet, or ankles, dizziness, and flushing. Perindopril may cause a persistent cough, dizziness, and headache. Both medications can lead to more serious side effects, such as severe allergic reactions, rapid heartbeat, or fainting. It's important to monitor for these effects and consult a healthcare provider if they occur. While both drugs aim to improve cardiovascular health, they can also cause fatigue and gastrointestinal issues, which should be reported to a doctor if persistent.
Can I take combination of Amlodipine and Perindopril with other prescription drugs?
Amlodipine can interact with other blood pressure medications, leading to an increased risk of low blood pressure. It may also interact with drugs like simvastatin, increasing the risk of side effects. Perindopril should not be used with certain diuretics or medications like aliskiren in patients with diabetes, as this can lead to serious kidney problems. Both medications can interact with NSAIDs, potentially reducing their effectiveness and increasing the risk of kidney damage. It's crucial to inform your healthcare provider of all medications you are taking to manage these interactions effectively.
Can I take combination of Amlodipine and Perindopril if I am pregnant?
Amlodipine's safety during pregnancy is not well-established, and it should only be used if no safer alternatives are available. Perindopril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including kidney damage and developmental issues. Women planning to become pregnant should discuss alternative treatments with their healthcare provider. If pregnancy occurs while taking these medications, immediate consultation with a healthcare provider is necessary to evaluate the risks and consider alternative therapies.
Can I take combination of Amlodipine and Perindopril while breastfeeding?
Amlodipine is excreted in human milk, but the effects on a breastfeeding infant are not well-documented, so caution is advised. Perindopril's safety during breastfeeding is not well-established, and alternative treatments with better-known safety profiles are generally recommended, especially for nursing newborns or preterm infants. If these medications are necessary, the benefits to the mother should be weighed against potential risks to the infant, and close monitoring is advised. Consulting a healthcare provider is crucial for making informed decisions about breastfeeding while on these medications.
Who should avoid taking combination of Amlodipine and Perindopril?
Amlodipine should be used cautiously in patients with severe low blood pressure or heart failure, as it can exacerbate these conditions. Perindopril is contraindicated in pregnancy due to the risk of harm to the fetus and should not be used in patients with a history of angioedema. Both medications require caution in patients with kidney or liver impairment. It's important to avoid abrupt discontinuation and to follow the prescribed dosage to prevent adverse effects. Regular monitoring by a healthcare provider is essential to manage these risks effectively.
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