Amlodipine + Perindopril
Find more information about this combination medication at the webpages for perindopril and amlodipine
.svg)
Advisory
- This medicine contains a combination of 2 drugs amlodipine and perindopril.
- amlodipine and perindopril are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
amlodipine + perindopril
Summary
Amlodipine is used to treat high blood pressure, which is also known as hypertension, and angina, which refers to chest pain caused by reduced blood flow to the heart. Perindopril is used to manage high blood pressure and improve heart function in people with heart failure, which is a condition where the heart doesn't pump blood as well as it should. Both help prevent heart attacks and strokes.
Amlodipine works by blocking calcium channels, which are pathways in blood vessels, helping them relax and widen, reducing blood pressure. Perindopril inhibits an enzyme that produces a hormone causing blood vessels to tighten, which helps them relax and lowers blood pressure. Both aim to reduce the heart's workload and improve blood flow, making them effective in managing high blood pressure and preventing heart-related issues.
Amlodipine is usually taken once daily, with doses ranging from 5 to 10 mg, depending on the individual's needs. Perindopril is also taken once daily, typically at a dose of 4 to 8 mg. Both medications are taken by mouth, which means they are swallowed as tablets. The exact dose may be adjusted by a healthcare provider based on blood pressure control and tolerance.
Common side effects of amlodipine include swelling of the ankles or feet, dizziness, and flushing, which is a warm, red feeling in the face. Perindopril may cause a dry cough, dizziness, and fatigue, which means feeling very tired. Both medicines can cause low blood pressure, leading to dizziness or fainting. It's important to monitor for these effects and consult a healthcare provider if they occur.
Amlodipine should be used cautiously in people with severe heart conditions, as it can affect heart rate and blood pressure. Perindopril is contraindicated during pregnancy, especially in the second and third trimesters, due to risks to the baby. Both require caution in people with kidney problems, as they can affect kidney function. Patients should inform their healthcare provider of any existing health conditions or medications to avoid potential risks.
Indications and Purpose
How does combination of amlodipine and perindopril work?
Amlodipine works by blocking calcium channels in the blood vessels, which helps to relax and widen them, reducing blood pressure and easing the heart's workload. Perindopril works by inhibiting an enzyme that produces a hormone causing blood vessels to tighten. This action helps to relax the blood vessels, lowering blood pressure and improving blood flow. Both medicines aim to reduce the strain on the heart and improve circulation, making them effective in managing high blood pressure and preventing heart-related issues.
How does combination of Amlodipine and Perindopril work?
Amlodipine works by blocking calcium channels in the smooth muscle of blood vessels, leading to relaxation and dilation of these vessels, which reduces blood pressure and alleviates angina. Perindopril, on the other hand, inhibits the angiotensin-converting enzyme (ACE), preventing the formation of angiotensin II, a substance that narrows blood vessels. This action also results in vasodilation and reduced blood pressure. Both medications ultimately aim to improve blood flow and reduce the workload on the heart, but they achieve this through different mechanisms.
How effective is combination of amlodipine and perindopril?
Clinical studies have shown that amlodipine effectively lowers blood pressure and reduces the risk of heart-related events by relaxing blood vessels. Perindopril has been proven to lower blood pressure and protect the heart by blocking a hormone that causes blood vessels to tighten. When used together, these medicines provide a complementary effect, enhancing blood pressure control and reducing cardiovascular risks. Both medicines have been widely studied and are considered effective in managing high blood pressure and preventing complications like heart attacks and strokes.
How effective is combination of Amlodipine and Perindopril?
The effectiveness of Amlodipine and Perindopril is supported by clinical studies and their widespread use in managing cardiovascular conditions. Amlodipine has been shown to effectively lower blood pressure and reduce angina attacks, improving exercise tolerance and quality of life. Perindopril has demonstrated benefits in reducing blood pressure, improving heart function, and decreasing the risk of heart attacks and strokes. Together, they provide a comprehensive approach to cardiovascular health by addressing different pathways, with Amlodipine offering immediate relief and Perindopril contributing to long-term management.
Directions for Use
What is the usual dose of combination of amlodipine and perindopril?
The usual adult daily dose of amlodipine ranges from 5 to 10 mg, depending on the individual's response and medical condition. Perindopril is typically prescribed at a dose of 4 to 8 mg per day. Both medicines are taken once daily, and the exact dose may be adjusted by a healthcare provider based on blood pressure control and tolerance. It's important to follow the prescribed dosage and not to adjust the dose without consulting a healthcare provider.
What is the usual dose of combination of Amlodipine and Perindopril?
The usual adult daily dose for Amlodipine is typically 5 mg to 10 mg once daily, depending on the patient's response and condition. For Perindopril, the usual starting dose is 4 mg once daily, which may be increased to 8 mg based on the patient's needs and tolerance. Both medications are taken orally and are often prescribed together to enhance blood pressure control. The combination allows for a synergistic effect, where Amlodipine provides immediate blood pressure reduction and Perindopril offers sustained control.
How does one take combination of amlodipine and perindopril?
Amlodipine and perindopril can be taken with or without food, making them convenient for daily use. It's important to take them at the same time each day to maintain consistent blood levels. While there are no specific food restrictions, it's advisable to avoid excessive salt intake, as it can counteract the blood pressure-lowering effects. Patients should follow their healthcare provider's dietary recommendations to enhance the effectiveness of the treatment.
How does one take combination of Amlodipine and Perindopril?
Amlodipine can be taken with or without food, while Perindopril is best taken before a meal to enhance absorption. Patients are advised to take these medications at the same time each day to maintain consistent blood levels. It's important to follow any dietary instructions provided by a healthcare provider, such as adhering to a low-salt diet, which can enhance the effectiveness of these medications. Patients should also avoid using salt substitutes containing potassium without consulting their doctor, as these can interact with Perindopril.
For how long is combination of amlodipine and perindopril taken?
Amlodipine and perindopril are typically used as long-term treatments for managing high blood pressure and preventing heart-related issues. The duration of use depends on the individual's condition and response to treatment. Regular monitoring by a healthcare provider is essential to assess effectiveness and make any necessary adjustments. Both medicines are intended for ongoing use to maintain blood pressure control and reduce the risk of complications like heart attacks and strokes.
For how long is combination of Amlodipine and Perindopril taken?
Amlodipine and Perindopril are typically used as long-term treatments for managing high blood pressure and coronary artery disease. Both medications are intended for continuous use to maintain their therapeutic effects, as they do not cure these conditions but help control them. Patients are advised to continue taking these medications even if they feel well, as stopping them without medical advice can lead to a return of symptoms or worsening of the condition. Regular monitoring by a healthcare provider is essential to ensure the medications are working effectively.
How long does it take for combination of amlodipine and perindopril to work?
Amlodipine, which is a calcium channel blocker, typically starts working within 24 to 48 hours to lower blood pressure. Perindopril, which is an ACE inhibitor, may take a bit longer, often a few days to a week, to show its full effect. Both medicines work to relax blood vessels, which helps to lower blood pressure and improve blood flow. The combination of these two medicines may provide a more comprehensive approach to managing high blood pressure, but the exact time it takes to feel the effects can vary from person to person.
How long does it take for combination of Amlodipine and Perindopril to work?
Amlodipine and Perindopril both work to lower blood pressure, but they do so in different ways. Amlodipine, a calcium channel blocker, typically starts to work within a few hours, with its peak effect occurring within 6 to 12 hours. Perindopril, an ACE inhibitor, also begins to lower blood pressure within a few hours, but its full effect may take several weeks to be realized. When combined, these medications can provide a more comprehensive approach to managing high blood pressure, with Amlodipine offering quicker relief and Perindopril contributing to long-term control.
Warnings and Precautions
Are there harms and risks from taking combination of amlodipine and perindopril?
Common side effects of amlodipine include swelling of the ankles or feet, dizziness, and flushing, which refers to a warm, red feeling in the face. Perindopril may cause a dry cough, dizziness, and fatigue, which means feeling very tired. Both medicines can cause low blood pressure, leading to dizziness or fainting. Serious side effects, though rare, can include severe allergic reactions or changes in kidney function. It's important to monitor for these effects and consult a healthcare provider if they occur. Both medicines aim to improve heart health but require careful monitoring.
Are there harms and risks from taking combination of Amlodipine and Perindopril?
Common side effects of Amlodipine include swelling of the hands, feet, or ankles, dizziness, and flushing. Perindopril may cause a persistent cough, dizziness, and headache. Both medications can lead to more serious side effects, such as severe allergic reactions, rapid heartbeat, or fainting. It's important to monitor for these effects and consult a healthcare provider if they occur. While both drugs aim to improve cardiovascular health, they can also cause fatigue and gastrointestinal issues, which should be reported to a doctor if persistent.
Can I take combination of amlodipine and perindopril with other prescription drugs?
Amlodipine can interact with other blood pressure medications, potentially leading to very low blood pressure. It may also interact with certain heart medications, affecting heart rate. Perindopril can interact with diuretics, increasing the risk of low blood pressure and high potassium levels. It may also interact with non-steroidal anti-inflammatory drugs (NSAIDs), which can reduce its effectiveness. Both medicines require careful monitoring when taken with other prescriptions, and patients should inform their healthcare provider of all medications they are taking to manage these interactions.
Can I take combination of Amlodipine and Perindopril with other prescription drugs?
Amlodipine can interact with other blood pressure medications, leading to an increased risk of low blood pressure. It may also interact with drugs like simvastatin, increasing the risk of side effects. Perindopril should not be used with certain diuretics or medications like aliskiren in patients with diabetes, as this can lead to serious kidney problems. Both medications can interact with NSAIDs, potentially reducing their effectiveness and increasing the risk of kidney damage. It's crucial to inform your healthcare provider of all medications you are taking to manage these interactions effectively.
Can I take combination of amlodipine and perindopril if I am pregnant?
Amlodipine is generally not recommended during pregnancy unless absolutely necessary, as its safety has not been fully established. Perindopril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of harm to the developing baby, including kidney damage and developmental issues. Both medicines should be avoided during pregnancy unless the benefits outweigh the risks. If a woman becomes pregnant while taking these medicines, she should consult her healthcare provider immediately to discuss alternative treatments.
Can I take combination of Amlodipine and Perindopril if I am pregnant?
Amlodipine's safety during pregnancy is not well-established, and it should only be used if no safer alternatives are available. Perindopril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including kidney damage and developmental issues. Women planning to become pregnant should discuss alternative treatments with their healthcare provider. If pregnancy occurs while taking these medications, immediate consultation with a healthcare provider is necessary to evaluate the risks and consider alternative therapies.
Can I take combination of amlodipine and perindopril while breastfeeding?
Amlodipine is considered to be relatively safe during breastfeeding, as only small amounts pass into breast milk. However, caution is advised, and monitoring the baby for any side effects is recommended. Perindopril is not recommended during breastfeeding, as it may pass into breast milk and affect the baby. Both medicines require careful consideration and consultation with a healthcare provider to weigh the benefits and risks. If a nursing mother needs treatment, alternative medications with a better safety profile during lactation may be considered.
Can I take combination of Amlodipine and Perindopril while breastfeeding?
Amlodipine is excreted in human milk, but the effects on a breastfeeding infant are not well-documented, so caution is advised. Perindopril's safety during breastfeeding is not well-established, and alternative treatments with better-known safety profiles are generally recommended, especially for nursing newborns or preterm infants. If these medications are necessary, the benefits to the mother should be weighed against potential risks to the infant, and close monitoring is advised. Consulting a healthcare provider is crucial for making informed decisions about breastfeeding while on these medications.
Who should avoid taking combination of amlodipine and perindopril?
Amlodipine should be used cautiously in people with severe heart conditions, as it can affect heart rate and blood pressure. Perindopril is contraindicated in pregnancy and should not be used by people with a history of angioedema, which is swelling under the skin. Both medicines require caution in people with kidney problems, as they can affect kidney function. It's important to monitor blood pressure and kidney function regularly. Patients should inform their healthcare provider of any existing health conditions or medications to avoid potential risks.
Who should avoid taking combination of Amlodipine and Perindopril?
Amlodipine should be used cautiously in patients with severe low blood pressure or heart failure, as it can exacerbate these conditions. Perindopril is contraindicated in pregnancy due to the risk of harm to the fetus and should not be used in patients with a history of angioedema. Both medications require caution in patients with kidney or liver impairment. It's important to avoid abrupt discontinuation and to follow the prescribed dosage to prevent adverse effects. Regular monitoring by a healthcare provider is essential to manage these risks effectively.
Forms / Brands
