Amlodipine + Olmesartan
Find more information about this combination medication at the webpages for olmesartan and amlodipine
Hypertension, Variant Angina Pectoris ... show more
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Advisory
- This medicine contains a combination of 2 drugs amlodipine and olmesartan.
- amlodipine and olmesartan are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker
Controlled Drug Substance
NO
amlodipine + olmesartan
Summary
Amlodipine and olmesartan are used to treat high blood pressure, which is also known as hypertension. By lowering blood pressure, they help reduce the risk of heart attacks and strokes. Amlodipine may also be used to treat chest pain, which is known as angina, due to its ability to improve blood flow. Together, they provide a comprehensive approach to managing blood pressure and related cardiovascular conditions.
Amlodipine works by relaxing blood vessels, which allows blood to flow more easily and lowers blood pressure. It is a calcium channel blocker, which means it prevents calcium from entering the cells of the heart and blood vessel walls. Olmesartan works by blocking a substance in the body that causes blood vessels to tighten. It is an angiotensin receptor blocker, which helps blood vessels relax and lowers blood pressure. Together, they effectively reduce blood pressure by different mechanisms.
The usual adult dose for amlodipine is 5 to 10 mg once daily, depending on the individual's response and medical condition. For olmesartan, the typical dose is 20 to 40 mg once daily. The exact dose may vary based on the patient's needs and how they respond to the treatment. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them. Both medicines are taken once a day, usually at the same time each day.
Common side effects of amlodipine include swelling of the ankles or feet, dizziness, and flushing, which is a feeling of warmth and redness in the face. Olmesartan may cause dizziness and a feeling of tiredness. Both medicines can cause low blood pressure, which might make you feel faint. Serious side effects are rare but can include severe allergic reactions or kidney problems. It's important to contact a healthcare provider if you experience any unusual symptoms or if common side effects persist.
Amlodipine should be used with caution in people with severe heart conditions, as it can affect heart rate and blood pressure. Olmesartan is contraindicated in pregnancy due to the risk of harm to the unborn baby. Both medicines should be used carefully in people with kidney or liver problems. It's important to regularly monitor blood pressure and kidney function. Always inform your healthcare provider about any existing health conditions before starting these medications.
Indications and Purpose
How does combination of amlodipine and olmesartan work?
Amlodipine works by relaxing the blood vessels, which allows blood to flow more easily and lowers blood pressure. It is a calcium channel blocker, which means it prevents calcium from entering the cells of the heart and blood vessel walls. Olmesartan works by blocking a substance in the body that causes blood vessels to tighten. It is an angiotensin receptor blocker, which helps blood vessels relax and lowers blood pressure. Together, they effectively reduce blood pressure by different mechanisms.
How does combination of Amlodipine and Olmesartan work?
Amlodipine and Olmesartan work together to lower blood pressure through different mechanisms. Amlodipine, a calcium channel blocker, relaxes blood vessels by inhibiting calcium ions from entering vascular smooth muscle cells, leading to vasodilation and reduced blood pressure. Olmesartan, an angiotensin II receptor blocker, prevents angiotensin II from binding to its receptors, which stops blood vessels from constricting and helps lower blood pressure. Together, they provide a synergistic effect, enhancing overall blood pressure control.
How effective is combination of amlodipine and olmesartan?
Studies have shown that amlodipine and olmesartan are effective in lowering blood pressure. Amlodipine works by relaxing the blood vessels, while olmesartan blocks substances that tighten blood vessels. Clinical trials have demonstrated that when used together, these medicines can significantly reduce blood pressure more than when used alone. This combination is particularly beneficial for people who need more than one medication to control their blood pressure. The effectiveness is usually assessed through regular blood pressure monitoring.
How effective is combination of Amlodipine and Olmesartan?
Clinical trials have demonstrated the effectiveness of Amlodipine and Olmesartan in lowering blood pressure. Amlodipine, as a calcium channel blocker, has been shown to reduce blood pressure and improve symptoms of angina. Olmesartan, an angiotensin II receptor blocker, effectively lowers blood pressure by preventing blood vessel constriction. Together, they provide a comprehensive approach to managing hypertension, with studies showing significant reductions in both systolic and diastolic blood pressure compared to monotherapy. This combination is particularly effective in patients who require multiple agents to achieve their blood pressure goals.
Directions for Use
What is the usual dose of combination of amlodipine and olmesartan?
The usual adult dose for amlodipine is 5 to 10 mg once daily, depending on the individual's response and medical condition. For olmesartan, the typical dose is 20 to 40 mg once daily. The exact dose may vary based on the patient's needs and how they respond to the treatment. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them. Both medicines are taken once a day, usually at the same time each day.
What is the usual dose of combination of Amlodipine and Olmesartan?
The usual starting dose for Amlodipine is 5 mg once daily, which can be increased to a maximum of 10 mg daily based on the patient's response and tolerance. For Olmesartan, the typical starting dose is 20 mg once daily, which can be increased to a maximum of 40 mg daily. When combined, the starting dose of Amlodipine and Olmesartan is often 5/20 mg once daily, with adjustments made as needed to achieve optimal blood pressure control. Both medications are taken orally and can be administered with or without food.
How does one take combination of amlodipine and olmesartan?
Amlodipine and olmesartan can be taken with or without food, making it convenient for daily use. It's important to take them at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but it's advisable to avoid excessive consumption of potassium-rich foods, as olmesartan can increase potassium levels. Always follow your healthcare provider's instructions and inform them of any dietary supplements you are taking.
How does one take combination of Amlodipine and Olmesartan?
Amlodipine and Olmesartan can be taken with or without food, making them convenient for daily use. It is important to take the medication at the same time each day to maintain consistent blood levels. Patients should follow any specific dietary instructions provided by their healthcare provider, such as a low-salt diet, to enhance the medication's effectiveness. There are no specific food restrictions, but patients should avoid using potassium supplements or salt substitutes containing potassium without consulting their doctor.
For how long is combination of amlodipine and olmesartan taken?
Amlodipine and olmesartan are typically used as long-term treatments for high blood pressure. The duration of use depends on the individual's response and medical condition. It's important to continue taking the medication even if you feel well, as high blood pressure often has no symptoms. Regular check-ups with your healthcare provider will help determine the ongoing need for these medications. Never stop taking them without consulting your healthcare provider.
For how long is combination of Amlodipine and Olmesartan taken?
Amlodipine and Olmesartan are typically used as long-term treatments for managing high blood pressure. They do not cure hypertension but help control it, so they are usually taken indefinitely unless a healthcare provider advises otherwise. Regular monitoring by a healthcare professional is essential to ensure the medication continues to be effective and to adjust dosages if necessary. Both medications require consistent daily use to maintain their blood pressure-lowering effects.
How long does it take for combination of amlodipine and olmesartan to work?
Amlodipine, which is a calcium channel blocker, usually starts working within 24 to 48 hours to lower blood pressure. Olmesartan, which is an angiotensin receptor blocker, may take about 1 to 2 weeks to show its full effect. When combined, these medicines work together to help lower blood pressure more effectively, but it may take a few weeks to see the full benefits. It's important to keep taking the medicine as prescribed, even if you don't feel different right away.
How long does it take for combination of Amlodipine and Olmesartan to work?
Amlodipine and Olmesartan work together to lower blood pressure, but they have different onset times. Amlodipine, a calcium channel blocker, typically starts working within a few hours, with its full effect seen after several days of consistent use. Olmesartan, an angiotensin II receptor blocker, may take up to two weeks to show its full effect, although some blood pressure reduction can be noticed within the first week. Together, they provide a comprehensive approach to managing hypertension, with Amlodipine offering quicker initial relief and Olmesartan contributing to long-term control.
Warnings and Precautions
Are there harms and risks from taking combination of amlodipine and olmesartan?
Common side effects of amlodipine include swelling of the ankles or feet, dizziness, and flushing, which is a feeling of warmth and redness in the face. Olmesartan may cause dizziness and a feeling of tiredness. Both medicines can cause low blood pressure, which might make you feel faint. Serious side effects are rare but can include severe allergic reactions or kidney problems. It's important to contact a healthcare provider if you experience any unusual symptoms or if common side effects persist.
Are there harms and risks from taking combination of Amlodipine and Olmesartan?
Common side effects of Amlodipine include swelling of the hands, feet, ankles, or lower legs, dizziness, and flushing. Olmesartan may cause dizziness and, in rare cases, severe diarrhea. Both medications can cause nausea and fatigue. Serious adverse effects include more frequent or severe chest pain, rapid or irregular heartbeat, and fainting. Patients should report any severe or persistent side effects to their healthcare provider. Monitoring by a healthcare professional is important to manage any adverse effects and adjust treatment as necessary.
Can I take combination of amlodipine and olmesartan with other prescription drugs?
Amlodipine can interact with other blood pressure medications, leading to an increased risk of low blood pressure. It may also interact with heart medications like beta-blockers. Olmesartan can interact with drugs that affect kidney function, such as NSAIDs, which are non-steroidal anti-inflammatory drugs. Both medicines can interact with diuretics, which are water pills, increasing the risk of low blood pressure. It's important to inform your healthcare provider about all medications you are taking to avoid these interactions.
Can I take combination of Amlodipine and Olmesartan with other prescription drugs?
Amlodipine can interact with simvastatin, increasing its levels in the blood, so the dose of simvastatin should be limited. Olmesartan should not be used with aliskiren in patients with diabetes due to increased risks of adverse effects. Both medications can interact with NSAIDs, potentially reducing their effectiveness and affecting kidney function. Patients should inform their healthcare provider of all medications they are taking to avoid harmful interactions and ensure safe and effective treatment.
Can I take combination of amlodipine and olmesartan if I am pregnant?
Amlodipine is generally not recommended during pregnancy unless absolutely necessary, as its safety has not been fully established. Olmesartan is not safe during pregnancy, especially in the second and third trimesters, as it can harm the developing baby. If you are pregnant or planning to become pregnant, it's crucial to discuss alternative treatments with your healthcare provider. Both medicines should be used with caution and under medical supervision if there is a possibility of pregnancy.
Can I take combination of Amlodipine and Olmesartan if I am pregnant?
Amlodipine and Olmesartan are not recommended during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Olmesartan can cause injury or death to the developing fetus by affecting kidney function and blood pressure. Amlodipine's effects during pregnancy are less clear, but caution is advised. Women who are pregnant or planning to become pregnant should discuss alternative treatments with their healthcare provider to ensure the safety of their unborn child.
Can I take combination of amlodipine and olmesartan while breastfeeding?
Amlodipine is considered to be relatively safe during breastfeeding, as only small amounts pass into breast milk. However, olmesartan's safety during breastfeeding is not well established, and it is generally advised to avoid it. If you are breastfeeding, it's important to discuss with your healthcare provider to weigh the benefits and risks. They may suggest alternative medications that are safer during lactation.
Can I take combination of Amlodipine and Olmesartan while breastfeeding?
There is limited information on the safety of Amlodipine and Olmesartan during lactation. Amlodipine is known to be present in human milk, while Olmesartan has been found in animal milk. Due to the potential for adverse effects on the nursing infant, breastfeeding is not recommended during treatment with these medications. Nursing mothers should discuss alternative treatments with their healthcare provider to ensure the safety of their infant while managing their health condition.
Who should avoid taking combination of amlodipine and olmesartan?
Amlodipine should be used with caution in people with severe heart conditions, as it can affect heart rate and blood pressure. Olmesartan is contraindicated in pregnancy due to the risk of harm to the unborn baby. Both medicines should be used carefully in people with kidney or liver problems. It's important to regularly monitor blood pressure and kidney function. Always inform your healthcare provider about any existing health conditions before starting these medications.
Who should avoid taking combination of Amlodipine and Olmesartan?
Amlodipine and Olmesartan should not be used during pregnancy due to the risk of fetal harm. Patients with severe liver impairment should use these medications cautiously. Amlodipine may cause increased angina or myocardial infarction in patients with severe coronary artery disease. Olmesartan can cause severe diarrhea and weight loss, known as sprue-like enteropathy. Both medications can cause dizziness, so patients should avoid activities requiring alertness until they know how the drugs affect them. Regular monitoring by a healthcare provider is essential to manage these risks.
