Aliskiren + Valsartan
Find more information about this combination medication at the webpages for valsartan and aliskiren
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Renin Inhibitor
Controlled Drug Substance
NO
Summary
Aliskiren and valsartan are used to treat high blood pressure, which is when the force of blood against artery walls is too high. By lowering blood pressure, they help reduce the risk of heart disease, stroke, and kidney problems. Valsartan is also used to treat heart failure and improve survival after a heart attack. Both medicines aim to improve blood flow and reduce the heart's workload.
Aliskiren works by blocking renin, which is an enzyme that helps regulate blood pressure, reducing the production of angiotensin I. Valsartan blocks angiotensin II receptors, which relaxes blood vessels, allowing blood to flow more easily. Together, they provide a comprehensive approach to lowering blood pressure by targeting different points in the blood pressure regulation pathway.
The usual adult daily dose for aliskiren is 150 mg, which can be increased to 300 mg if needed. For valsartan, the common starting dose is 80 mg, adjustable up to 320 mg based on response. Both medicines are taken once daily, with or without food, but consistently in the same manner each day. Patients should follow their healthcare provider's instructions for dosage.
Common side effects of aliskiren include diarrhea and cough, while valsartan may cause dizziness and fatigue. Both medicines can lead to high potassium levels, known as hyperkalemia, and low blood pressure, called hypotension. Significant adverse effects shared by both include kidney problems and allergic reactions. Monitoring for these side effects is important, especially in patients with pre-existing conditions.
Aliskiren and valsartan should not be used during pregnancy due to the risk of fetal harm. They are contraindicated in patients with severe kidney impairment or a history of angioedema, which is swelling beneath the skin. Both can cause high potassium levels, so caution is advised in patients with kidney issues. Regular monitoring and communication with a healthcare provider are essential to manage these risks.
Indications and Purpose
How does combination of aliskiren and valsartan work?
Aliskiren works by inhibiting renin, which is an enzyme that plays a key role in the production of angiotensin I, a substance that narrows blood vessels. By blocking renin, aliskiren helps to lower blood pressure. Valsartan, on the other hand, blocks angiotensin II receptors, preventing angiotensin II from tightening blood vessels. This action helps to relax and widen the blood vessels, further reducing blood pressure. Both medicines aim to lower blood pressure but do so through different mechanisms, providing a comprehensive approach to managing hypertension.
How does combination of Aliskiren and Valsartan work?
The combination of Aliskiren and Valsartan is used to treat high blood pressure. Aliskiren is a type of medication known as a direct renin inhibitor. It works by blocking the action of renin, an enzyme in the body that helps regulate blood pressure. By inhibiting renin, Aliskiren reduces the production of substances that can tighten blood vessels, which helps to lower blood pressure. Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking the action of a chemical in the body called angiotensin II, which normally causes blood vessels to tighten. By blocking this chemical, Valsartan helps to relax and widen blood vessels, further reducing blood pressure. Together, these medications help to lower blood pressure more effectively than either drug alone, reducing the risk of complications such as heart attacks and strokes. It's important to follow your healthcare provider's instructions when taking these medications.
How effective is combination of aliskiren and valsartan?
Clinical studies have shown that both aliskiren and valsartan effectively lower blood pressure. Aliskiren, which inhibits renin, has been proven to reduce blood pressure by decreasing the production of angiotensin I, a precursor to angiotensin II. Valsartan, which blocks angiotensin II receptors, has demonstrated effectiveness in relaxing blood vessels and reducing blood pressure. When used together, these medicines provide a complementary approach, targeting different points in the blood pressure regulation pathway. This combination has been shown to be more effective than either medicine alone in achieving blood pressure control.
How effective is combination of Aliskiren and Valsartan?
The combination of Aliskiren and Valsartan is used to treat high blood pressure. Aliskiren is a direct renin inhibitor, which means it works by blocking a substance in the body that causes blood vessels to tighten. Valsartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels. Together, they can be more effective in lowering blood pressure than when each is used alone. However, this combination is not commonly recommended due to potential risks, such as kidney problems, high potassium levels, and low blood pressure, especially in certain populations. It's important to consult a healthcare provider to determine the best treatment plan for individual needs.
Directions for Use
What is the usual dose of combination of aliskiren and valsartan?
The usual adult daily dose for aliskiren is typically 150 mg, which can be increased to 300 mg if needed. For valsartan, the common starting dose is 80 mg, which can be adjusted up to 320 mg based on the patient's response and needs. Both medicines are taken once daily, and the exact dosage may vary depending on the individual's health condition and response to treatment. It's important for patients to follow their healthcare provider's instructions and not to adjust the dose without consulting them.
What is the usual dose of combination of Aliskiren and Valsartan?
The usual dose of the combination of Aliskiren and Valsartan can vary based on individual health needs and the specific condition being treated. However, a common starting dose is often 150 mg of Aliskiren combined with 160 mg of Valsartan, taken once daily. It's important to follow the dosage prescribed by a healthcare provider, as they will tailor it to your specific health requirements. Always consult with a healthcare professional before starting or adjusting any medication.
How does one take combination of aliskiren and valsartan?
Aliskiren and valsartan can be taken with or without food, but it's important to take them consistently in the same manner each day. Patients should avoid high-fat meals when taking aliskiren, as they can reduce its absorption. It's also advised to avoid potassium-rich foods and salt substitutes containing potassium, as these can increase the risk of high potassium levels. Patients should follow their healthcare provider's instructions regarding diet and medication timing to ensure the best results and minimize side effects.
How does one take combination of Aliskiren and Valsartan?
Aliskiren and Valsartan are medications used to treat high blood pressure. When taken together, they work by relaxing blood vessels, making it easier for the heart to pump blood. This combination should be taken exactly as prescribed by a healthcare provider. It is usually taken once a day, with or without food. It's important to take it at the same time each day to maintain an even level of medication in your body. Do not take more or less than the prescribed dose, and do not stop taking it without consulting your doctor, as this could worsen your condition. Always follow your healthcare provider's instructions and discuss any concerns or side effects you experience.
For how long is combination of aliskiren and valsartan taken?
Aliskiren and valsartan are typically used as long-term treatments for managing high blood pressure. The duration of use depends on the individual's response to the medication and their overall health condition. Patients may need to take these medicines indefinitely to maintain blood pressure control and reduce the risk of cardiovascular complications. Regular follow-ups with a healthcare provider are important to assess the effectiveness of the treatment and make any necessary adjustments. It's crucial not to stop taking the medication without consulting a healthcare provider.
For how long is combination of Aliskiren and Valsartan taken?
The duration for taking a combination of Aliskiren and Valsartan depends on the individual's medical condition and response to treatment. It is typically prescribed for long-term use to manage high blood pressure. However, the exact duration should be determined by a healthcare professional, who will consider factors like the patient's overall health, blood pressure goals, and any side effects experienced. Regular follow-ups with a doctor are important to assess the effectiveness and safety of the treatment.
How long does it take for combination of aliskiren and valsartan to work?
Aliskiren and valsartan, when combined, typically start working within a few hours to lower blood pressure. Aliskiren, which is a direct renin inhibitor, begins to reduce blood pressure by blocking the enzyme renin, which is involved in blood pressure regulation. Valsartan, which is an angiotensin receptor blocker, works by relaxing blood vessels, allowing blood to flow more easily. Both medicines share the common goal of reducing blood pressure, but they achieve this through different mechanisms. The full effect of the combination may take a few weeks to be fully realized.
How long does it take for combination of Aliskiren and Valsartan to work?
The combination of Aliskiren and Valsartan is used to treat high blood pressure. According to information from trusted sources like the NHS and NLM, it may take a few weeks to see the full effects of this medication on blood pressure. However, some people might notice improvements in their blood pressure within a week or two. It's important to continue taking the medication as prescribed by your healthcare provider, even if you don't feel different, because high blood pressure often doesn't have noticeable symptoms.
Warnings and Precautions
Are there harms and risks from taking combination of aliskiren and valsartan?
Common side effects of aliskiren include diarrhea and cough, while valsartan may cause dizziness and fatigue. Both medicines can lead to increased potassium levels, which is known as hyperkalemia, and low blood pressure, which is called hypotension. Significant adverse effects shared by both include kidney problems and allergic reactions. It's important to monitor for these side effects, especially in patients with pre-existing kidney conditions or those taking other medications that affect kidney function. Regular check-ups with a healthcare provider can help manage and mitigate these risks.
Are there harms and risks from taking combination of Aliskiren and Valsartan?
Yes, there are potential harms and risks when taking Aliskiren and Valsartan together. Both drugs are used to treat high blood pressure, but combining them can increase the risk of kidney problems, high potassium levels, and low blood pressure. High potassium levels can lead to serious heart issues, while low blood pressure can cause dizziness and fainting. It's important to consult a healthcare professional before combining these medications to ensure it's safe based on your individual health condition.
Can I take combination of aliskiren and valsartan with other prescription drugs?
Aliskiren and valsartan can interact with other blood pressure medications, such as ACE inhibitors and diuretics, increasing the risk of low blood pressure and kidney problems. They may also interact with NSAIDs, reducing their effectiveness and potentially harming the kidneys. Additionally, drugs that increase potassium levels, like certain diuretics, can lead to hyperkalemia. Patients should inform their healthcare provider about all medications they are taking to avoid harmful interactions. Regular monitoring of blood pressure, kidney function, and potassium levels is important to manage these interactions effectively.
Can I take combination of Aliskiren and Valsartan with other prescription drugs?
Aliskiren and Valsartan are medications used to treat high blood pressure. Combining these drugs with other prescription medications can sometimes lead to interactions that may affect how well the drugs work or increase the risk of side effects. 1. **Aliskiren**: This drug works by inhibiting renin, an enzyme involved in blood pressure regulation. It should not be taken with certain medications like ACE inhibitors or ARBs (Angiotensin Receptor Blockers) in patients with diabetes or kidney problems, as it can increase the risk of kidney damage, high potassium levels, and low blood pressure. 2. **Valsartan**: This is an ARB that helps relax blood vessels. It can interact with other medications that affect potassium levels, such as potassium supplements or certain diuretics, leading to high potassium levels in the blood. Before taking Aliskiren and Valsartan with other prescription drugs, it is important to consult with a healthcare provider. They can provide guidance based on your specific health needs and the medications you are currently taking. Always inform your doctor about all the medications you are using, including over-the-counter drugs and supplements, to avoid potential interactions.
Can I take combination of aliskiren and valsartan if I am pregnant?
Aliskiren and valsartan are not recommended during pregnancy due to potential harm to the developing fetus. Both medicines can affect the renin-angiotensin system, which is crucial for fetal kidney development. This can lead to serious complications, including fetal injury or death. If a patient becomes pregnant while taking these medications, they should contact their healthcare provider immediately. Alternative treatments that are safer during pregnancy should be considered. It's important for women of childbearing age to discuss contraception and pregnancy plans with their healthcare provider when using these medications.
Can I take combination of Aliskiren and Valsartan if I am pregnant?
No, you should not take a combination of Aliskiren and Valsartan if you are pregnant. Both of these medications can harm an unborn baby. Aliskiren and Valsartan are used to treat high blood pressure, but during pregnancy, they can affect the baby's development and lead to serious complications. If you are pregnant or planning to become pregnant, consult your healthcare provider for safer alternatives.
Can I take combination of aliskiren and valsartan while breastfeeding?
The safety of aliskiren and valsartan during lactation and breastfeeding is not well established. Both medicines may pass into breast milk, potentially affecting the nursing infant. Due to the lack of sufficient data, healthcare providers often recommend alternative treatments for managing high blood pressure in breastfeeding mothers. If a mother needs to take these medications, she should discuss the potential risks and benefits with her healthcare provider. Monitoring the infant for any adverse effects is crucial if these medicines are used during breastfeeding.
Can I take combination of Aliskiren and Valsartan while breastfeeding?
According to the NHS, it is important to be cautious when taking any medication while breastfeeding. Aliskiren and Valsartan are medications used to treat high blood pressure. Aliskiren works by blocking a substance in the body that causes blood vessels to tighten, while Valsartan helps relax blood vessels so blood can flow more easily. The safety of using Aliskiren and Valsartan during breastfeeding is not well established. The NHS advises consulting with a healthcare professional to weigh the potential benefits and risks before using these medications while breastfeeding. They can provide guidance based on your specific health needs and the health of your baby.
Who should avoid taking combination of aliskiren and valsartan?
Aliskiren and valsartan should not be used during pregnancy due to the risk of fetal harm. They are also contraindicated in patients with severe kidney impairment or those with a history of angioedema, which is swelling beneath the skin. Both medicines can cause high potassium levels, so caution is advised in patients with kidney issues or those taking potassium supplements. Patients should be aware of the risk of low blood pressure, especially when starting treatment or increasing the dose. Regular monitoring and communication with a healthcare provider are essential to manage these risks.
Who should avoid taking combination of Aliskiren and Valsartan?
People with diabetes or kidney problems should avoid taking a combination of Aliskiren and Valsartan. This combination can increase the risk of serious side effects, such as kidney damage, high potassium levels, and low blood pressure. Additionally, pregnant women should not use this combination due to potential harm to the unborn baby. Always consult a healthcare professional before starting or stopping any medication.
