Is it better to take losartan twice a day?
Nov 3, 2023
Is it better to take losartan twice a day?
Based on preliminary findings it appears that administering perindopril or losartan twice daily with the same daily dosage yields better results in reducing the nondipper phenomenon when compared to the oncedaily evening administration This conclusion is drawn from a study conducted to investigate the efficacy of different dosing regimens in addressing this particular issue The nondipper phenomenon refers to a condition in which blood pressure fails to decrease significantly during sleep putting individuals at a higher risk of cardiovascular complications To explore potential solutions researchers compared the effects of twicedaily administration with a consistent daily dosage of either perindopril or losartan against the oncedaily evening administration The preliminary results indicate that more frequent dosing resulted in a more pronounced reduction in the nondipper phenomenon This suggests that splitting the same daily dosage into two administrations throughout the day leads to better control of blood pressure during sleep This finding is particularly significant as effective blood pressure control during sleep plays a crucial role in minimizing cardiovascular risks Although further research is needed to confirm these findings the preliminary data suggests that adjusting the dosing regimen by administering perindopril or losartan twice daily could be beneficial for individuals experiencing the nondipper phenomenon By optimizing blood pressure control during sleep this approach may help mitigate the associated risks and improve cardiovascular outcomes
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