How long does losartan stay in the body?
Nov 3, 2023
How long does losartan stay in the body?
The terminal halflife of losartan a medication commonly used to treat high blood pressure is approximately 2 hours This means that it takes about 2 hours for half of the drug to be eliminated from the body On the other hand the halflife of the metabolite a substance formed as a result of losartan metabolism is about 69 hours This means it takes longer for the metabolite to be eliminated from the body compared to the parent drug When losartan is taken orally as a single dose only a small percentage of the drug is excreted unchanged in the urine around 4 The majority approximately 6 of the dose is excreted in the urine as an active metabolite This suggests that the metabolite plays a significant role in the pharmacological activity of losartan Understanding the pharmacokinetic profile of losartan and its metabolite is important for dosing and monitoring of patients The relatively short halflife of losartan indicates that frequent dosing may be necessary to maintain therapeutic levels in the blood Additionally the presence of the active metabolite in urine highlights the importance of renal function in the clearance of losartan from the body
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For information purposes only. Consult a doctor before taking any medicines.
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