mainstay (LOSARTAN)
Introduction to Mainstay
Mainstay is a medication primarily used to manage and treat conditions related to high blood pressure, heart failure, and kidney disease in diabetes. It is also effective in re... See More
What is Mainstay?
Mainstay is an angiotensin II receptor blocker (ARB) commonly used to treat high blood pressure (hypertension) and heart failure. It is also prescribed to protect the kidneys in diabetic nephropathy. Mainstay works by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thus helping to relax and widen blood vessels, lowering blood pressure and improving heart function.
How do I take Mainstay?
Mainstay can be taken with or without food. There are no specific food restrictions, but avoid high-potassium foods or supplements as Mainstay can increase potassium levels. Take once daily, at the same time each day. Swallow the tablet whole, without crushing or chewing. Follow your doctor’s advice on potassium intake and other medications you may be taking.
For how long do I take Mainstay?
Mainstay is often a medicine you take for a long time, maybe even your whole life.
What is Mainstay used for?
Mainstay is indicated for treating hypertension (high blood pressure), heart failure, and diabetic nephropathy (kidney disease in diabetes). It’s also used to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (enlarged heart). Mainstay helps lower blood pressure and protect kidney function, improving overall cardiovascular health.
How long does it take for Mainstay to start working?
Your blood pressure may go down in the first week of taking Mainstay, but it may take up to 6 weeks to feel the full effects.
Is Mainstay effective?
Evidence supporting Mainstay’s effectiveness comes from clinical trials showing it significantly reduces blood pressure, improving cardiovascular outcomes. Studies like the Mainstay Heart Failure Study demonstrated its ability to reduce symptoms and hospitalizations in heart failure patients. It also effectively protects kidney function in those with diabetic nephropathy and reduces the risk of stroke in high-risk patients.
How does one know if Mainstay is working?
The benefit of Mainstay is evaluated by regularly monitoring blood pressure to ensure it stays within the target range. In patients with heart failure or diabetic nephropathy, kidney function and creatinine levels are also monitored. Additionally, doctors may assess heart function and symptoms to determine if the medication is effectively improving overall cardiovascular health and reducing risks.
How does Mainstay work?
Mainstay works by blocking the action of angiotensin II, a hormone that constricts blood vessels and raises blood pressure. By blocking angiotensin II receptors, Mainstay helps relax and widen blood vessels, which lowers blood pressure. This action improves heart function, reduces strain on the heart, and helps protect the kidneys, particularly in people with diabetes.
Who should avoid taking Mainstay?
Mainstay is contraindicated in pregnancy, particularly in the second and third trimesters, due to risks to the fetus. It should not be used in patients with severe liver impairment or allergy to the drug. Caution is advised for those with kidney problems, low blood pressure, or high potassium levels. Regular monitoring of blood pressure, kidney function, and potassium is important.
Can I take Mainstay with vitamins or supplements?
Significant interactions with Mainstay include potassium supplements or high-potassium foods (e.g., bananas, spinach), which can increase the risk of hyperkalemia (high potassium levels). Vitamin D and calcium supplements may also affect Mainstay's effectiveness. It’s important to consult a healthcare provider before taking any vitamins or supplements to avoid interactions that could impact blood pressure or kidney function.
Can I take Mainstay with other prescription drugs?
Significant interactions with Mainstay include diuretics (e.g., spironolactone) which may increase the risk of low blood pressure or kidney problems. ACE inhibitors (e.g., enalapril) or renin inhibitors (e.g., aliskiren) can cause hyperkalemia and kidney issues. NSAIDs (e.g., ibuprofen) may reduce Mainstay’s effectiveness and harm kidney function. Always consult your doctor about all medications you're taking.
Can Mainstay be taken safely while pregnant?
Mainstay is a medication that should not be taken by pregnant women. If taken during pregnancy, it can decrease the amount of fluid surrounding the developing baby, especially in the second and third trimesters. This can cause harm to the baby's kidneys and lungs, leading to long-term health issues. If you discover you are pregnant while taking Mainstay, stop taking it and consult your doctor immediately.
Can Mainstay be taken safely while breastfeeding?
It's usually okay to breastfeed while taking Mainstay, but it's important to talk to your doctor first. However, if your baby was born prematurely, it's best to avoid taking Mainstay. Your doctor can help you decide the best course of action.
Is Mainstay safe for the elderly?
Mainstay is a medicine for high blood pressure and kidney protection in people with type 2 diabetes. In studies, a smaller percentage of older people (65 and older) took part in the high blood pressure trials compared to the diabetes trials. Doctors found Mainstay worked similarly well in both younger and older adults, but some older people might be more sensitive to it. It's important for doctors to check potassium levels in the blood regularly, and they may need to adjust the dose or stop the medicine if necessary.
How should I store Mainstay?
To keep your Mainstay medicine in good condition, store it properly. Put it in a container that closes tightly to keep out light. The temperature should stay between 59°F to 86°F (15°C to 30°C). Most importantly, keep it and all other medicines out of reach of children for safety.
Does Mainstay make people tired or drowsy?
Yes, Mainstay can cause dizziness, which was reported in 3% of patients in clinical trials. If you experience dizziness or lightheadedness, especially after getting up from a lying or sitting position, get up slowly and talk to your doctor.
Does Mainstay cause stomach upset?
Yes, Mainstay can cause stomach upset like abdominal pain, nausea, vomiting, and diarrhea. These side effects were reported in less than 2% of patients. If you experience gastrointestinal issues, consult your doctor for advice on managing these side effects.
Does Mainstay affect sleep?
Mainstay can cause sleep disorders. If you experience a change in sleep, talk to your doctor to see if they recommend any changes to your medication or sleep habits.
Does Mainstay make it hard to think or concentrate?
Yes, Mainstay may affect your ability to think or concentrate. Side effects like somnolence and headache can cause problems with concentration, attention, and memory. If you experience these side effects, talk to your doctor.
Does Mainstay affect mood?
Yes, Mainstay can affect your mood. It may cause depression. If you experience mood swings, depression, or anxiety while taking this medication, it is important to consult your doctor for further evaluation and guidance.
Does Mainstay interfere with sexual function?
Yes, Mainstay can cause impotence. If you experience sexual side effects while taking Mainstay, talk to your doctor as they may be able to adjust your dose or suggest alternative treatments.
Does Mainstay affect appetite?
There is no enough data to prove that Mainstay affects appetite.
Does Mainstay cause weight gain?
Weight gain is not a commonly reported side effect of Mainstay. In fact, it is more likely to cause weight loss in rare cases due to its potential impact on fluid retention and blood pressure.
Does Mainstay cause headaches?
Mainstay can cause headaches. If you experience headaches while taking Mainstay, talk to your doctor to see if they recommend any changes to your medication or over-the-counter pain relief.
Does Mainstay limit driving?
Mainstay can cause dizziness. If you experience dizziness, do not drive or operate machinery.
Is it safe to drink alcohol while taking Mainstay?
Alcohol can lower blood pressure, which might amplify Mainstay's effects and cause dizziness or fainting. It's best to limit alcohol intake and consult your doctor for personalized advice.
Is it safe to drink coffee or tea while taking Mainstay?
Moderate consumption of coffee or tea is generally safe, but caffeine can sometimes raise blood pressure slightly. If you're concerned, talk to your doctor or pharmacist.
Is it safe to exercise while taking Mainstay?
Regular exercise is beneficial, but since Mainstay lowers blood pressure, you may feel dizzy during activity. Speak to your doctor before starting a new or intense exercise routine to ensure safety.
What are Mainstay possible harms and risks?
Common side effects of Mainstay include dizziness, headache, fatigue, and nasal congestion. Significant adverse effects may include low blood pressure (hypotension), elevated potassium levels (hyperkalemia), and kidney problems. In rare cases, it can cause angioedema (swelling of deeper layers of skin). Serious side effects require immediate medical attention.
Available in 2 variations
Mainstay 25mg Tablet
Mainstay 25mg Tablet
Losartan (25mg)
strip of 10 tablets
Mainstay 50mg Tablet
Mainstay 50mg Tablet
Losartan (50mg)
strip of 10 tablets
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