closum (CLOBAZAM)
What is Closum?
Closum is a medication commonly used to treat seizures, particularly in conditions like epilepsy, and it is also used to manage anxiety disorders. It works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps to calm abnormal electrical activity in the brain. This action helps to reduce the frequency and severity of seizures and promotes relaxation in the nervous system.
What is the usual dose of Closum?
The usual daily dose of Closum for adults is 10 mg initially, increasing to a maximum of 40 mg per day. For children aged 2 years and older, those over 30 kg may start at 10 mg (max 40 mg), while those 30 kg or less may start at 5 mg (max 20 mg).
How do I take Closum?
Closum can be taken with or without food, depending on personal preference. There are no specific food restrictions associated with this medicine. However, it is important to follow your healthcare provider’s instructions regarding the dosage and timing. If you experience any stomach discomfort, taking it with food may help reduce irritation. Always take Closum as prescribed.
For how long do I take Closum?
Closum is a medicine that can be addictive if used for a long time or at high doses. To avoid addiction and unpleasant withdrawal symptoms, it's important to gradually reduce the dosage when stopping the medication.
What is Closum used for?
Closum is commonly used to treat seizure disorders, particularly Lennox-Gastaut syndrome in children and adults. It is also prescribed for anxiety disorders or short-term relief of symptoms of anxiety in some cases. Additionally, it can be used as part of the treatment for epilepsy to help control certain types of seizures.
How long does it take for Closum to start working?
Closum typically starts to work within 1 to 2 hours after taking it. However, it may take a few days to weeks for its full effects to be felt, especially for conditions like epilepsy or anxiety. It is important to continue taking the medication as prescribed, even if you don't notice immediate effects.
Is Closum effective?
Closum has been shown to be effective in treating seizures in various clinical trials, particularly in patients with epilepsy. Studies demonstrate that it significantly reduces the frequency of seizures and improves overall quality of life in individuals with Lennox-Gastaut syndrome and other seizure disorders. Clinical evidence supports its use as an add-on therapy for drug-resistant seizures, showing its ability to lower seizure rates compared to placebo.
How does one know if Closum is working?
The benefit of Closum is typically evaluated through clinical assessments of seizure frequency, intensity, and duration in patients with epilepsy or seizure disorders. Regular monitoring includes keeping track of seizure diaries, patient-reported outcomes, and possibly EEG tests to assess brain activity. Additionally, improvements in overall quality of life and cognitive function are considered to evaluate its therapeutic effectiveness.
How does Closum work?
Closum works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that inhibits nerve activity. This action helps to calm overactive neurons, reducing the likelihood of seizures. Closum binds to GABA-A receptors and increases the receptor's sensitivity to GABA, which in turn relaxes the brain's nervous system and provides anti-anxiety and anticonvulsant effects.
Who should avoid taking Closum?
Closum has warnings for causing sedation, respiratory depression, and dependence with long-term use. It is contraindicated in individuals with severe liver impairment, hypersensitivity to benzodiazepines, or a history of substance abuse. Caution is advised for pregnant or breastfeeding women and those operating heavy machinery due to its sedative effects. Always use under medical supervision.
Can I take Closum with vitamins or supplements?
Closum may interact with supplements that cause sedation, such as valerian root, melatonin, or St. John’s wort, increasing drowsiness. Magnesium and calcium supplements can affect its absorption if taken simultaneously. Always inform your doctor about any vitamins or supplements you are using to avoid unwanted interactions and ensure safe use of Closum.
Can I take Closum with other prescription drugs?
Mixing Closum with opioids, alcohol, or sedatives (like sleeping pills or anti-anxiety meds) is dangerous. It can make you extremely sleepy, slow your breathing, and even cause you to pass out or die. It's important to avoid these combinations and to always follow your doctor's instructions carefully when taking Closum.
Can Closum be taken safely while pregnant?
Closum use during pregnancy is generally not recommended due to potential risks to the fetus, including withdrawal symptoms, sedation, or breathing issues after birth. It may also increase the risk of congenital malformations, especially if used in the first trimester. Pregnant individuals should consult their doctor to weigh the benefits and risks of using Closum.
Can Closum be taken safely while breastfeeding?
Closum is excreted into breast milk, and its use during breastfeeding is not generally recommended. It may cause sedation, poor feeding, or difficulty breathing in the nursing infant. If Closum must be used, close monitoring of the baby for side effects is essential. Consult a healthcare provider before using this medication while breastfeeding.
Is Closum safe for the elderly?
For older adults, start with a low dose of 5 mg each day. Gradually increase the dose to 10-20 mg per day, as tolerated. The highest dose that should be taken is 40 mg daily. Older adults may need a lower dose because their bodies take longer to remove the medication.
How should I store Closum?
Keep Closum at regular room temperature, between 68°F to 77°F (20°C to 25°C), in a dry place. Make sure to store Closum and all other medications out of reach of children.
Does Closum make people tired or drowsy?
Yes, drowsiness and fatigue are common with Closum, affecting more than 10% of users. If you feel excessively tired, avoid driving or operating heavy machinery. Contact your doctor if drowsiness impacts your daily activities or does not improve over time.
Does Closum cause stomach upset?
Closum can occasionally cause nausea, constipation, or diarrhea. These side effects are not very common, but taking it with food might help reduce discomfort. Notify your doctor if stomach upset persists or worsens.
Does Closum affect sleep?
Closum is often used to promote relaxation and may help with sleep issues related to anxiety. However, it can also lead to excessive sedation in some cases. If sleep disturbances occur, discuss dose adjustments with your doctor.
Does Closum make it hard to think or concentrate?
Cognitive side effects like difficulty concentrating, forgetfulness, or slowed thinking can occur, particularly at higher doses. If Closum interferes with your focus or memory, inform your doctor for guidance on managing the dosage or timing of the medication.
Does Closum affect mood?
Mood swings, including irritability or agitation, can occur in some users of Closum. If these symptoms affect daily life, contact your doctor. Severe mood changes may require adjusting the medication or exploring alternatives.
Does Closum interfere with sexual function?
Closum rarely causes sexual dysfunction like decreased libido or difficulties with arousal. If you notice sexual side effects that affect your well-being, consult your doctor to discuss adjustments to your treatment.
Does Closum affect appetite?
Closum can sometimes lead to decreased appetite, although it is not a frequent side effect. If appetite changes become significant or persist, notify your healthcare provider.
Does Closum cause weight gain?
Weight gain is not a common side effect of Closum, but changes in appetite or decreased activity from sedation may contribute indirectly. Talk to your doctor if you notice significant weight changes.
Does Closum cause headaches?
Headaches may occur as a rare side effect of Closum. Over-the-counter pain relievers can help, but if headaches become persistent or severe, consult your doctor for advice.
Does Closum limit driving?
Yes, Closum can impair driving due to drowsiness, slowed reflexes, or dizziness. Avoid driving or operating heavy machinery until you understand how the medicine affects you.
Is it safe to drink alcohol while taking Closum?
It is unsafe to drink alcohol while taking Closum. Alcohol can increase side effects like drowsiness, dizziness, and the risk of breathing problems. Avoid drinking entirely during treatment for your safety.
Is it safe to drink coffee or tea while taking Closum?
Drinking coffee or tea is generally safe with Closum. However, caffeine might reduce the calming effects of the medicine, so monitor how your body reacts to combining the two and moderate intake if needed.
Is it safe to exercise while taking Closum?
Exercise is safe while taking Closum, but avoid strenuous activities if you experience drowsiness, dizziness, or lack of coordination. Start with light exercises and increase intensity gradually as tolerated. Stay hydrated and stop if you feel unwell.
What are Closum possible harms and risks?
Common side effects of Closum include drowsiness, fatigue, dizziness, and impaired coordination. Significant adverse effects may include respiratory depression, severe allergic reactions, mood changes, dependence, or withdrawal symptoms. Always consult a doctor if severe reactions occur.
Available in 2 variations
Closum 20mg Tablet MD
Closum 20mg Tablet MD
Clobazam (20mg)
strip of 10 tablet md
Closum 10mg Tablet MD
Closum 10mg Tablet MD
Clobazam (10mg)
strip of 10 tablet md
.svg)
