Nitrofurantoin
Escherichia coli Infections, Staphylococcal Infections ... show more
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
YES
Teratogenicity
Unlisted
Pharmaceutical Class
Antibacterial
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Nitrofurantoin
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Click HereSummary
Nitrofurantoin is an antibiotic used to treat urinary tract infections (UTIs) caused by bacteria. It's effective against some common bacteria, but not all. It's not used for kidney infections or serious infections around the kidney.
Nitrofurantoin works by inhibiting bacterial enzymes and interfering with bacterial metabolism, effectively killing the bacteria causing the infection. This multi-pronged approach makes it difficult for bacteria to become resistant to the drug.
Adults usually take 50 to 100 milligrams of Nitrofurantoin four times a day, but less might be used for simple bladder infections. Children's doses depend on their weight, with 5 to 7 milligrams for every kilogram they weigh, spread out over four doses daily. Babies younger than one month shouldn't take it.
Nitrofurantoin can sometimes cause side effects like nausea, vomiting, diarrhea, dizziness, sleepiness, unsteadiness, and headaches. Weight gain is not a typical side effect. It can also cause serious lung or liver problems and nerve damage, although these are not common.
Nitrofurantoin can be harmful to your kidneys, especially if they're not working well. Pregnant women near their due date, newborns, and people with liver problems shouldn't take it. It can cause nerve damage, especially in people with kidney problems or diabetes, and lung problems, ranging from temporary coughs to permanent lung damage.
Indications and Purpose
What is Nitrofurantoin used for?
Nitrofurantoin is an antibiotic that fights bacteria causing bladder infections. It works against some common bacteria, but not all. It's *not* used for kidney infections (pyelonephritis) or serious infections around the kidney (perinephric abscesses).
How does Nitrofurantoin work?
Nitrofurantoin works by inhibiting bacterial enzymes, interfering with bacterial metabolism, and killing the bacteria causing the infection.
Is Nitrofurantoin effective?
Nitrofurantoin is an antibiotic that works in many ways to stop bacteria from growing. It messes with several important parts of a bacteria's life, making it hard for them to survive. This multi-pronged approach makes it difficult for bacteria to become resistant to the drug. Even after taking it for a week, a significant amount of the medicine is still found in the urine, showing that it effectively reaches the urinary tract where it's needed to fight infection.
How does one know if Nitrofurantoin is working?
Nitrofurantoin's effectiveness against bacteria is checked using a lab test. The test measures how much of the drug is needed to stop the bacteria's growth. If 90% or more of the bacteria are stopped by a certain amount of the drug, it's considered effective. However, there aren't enough studies to prove it works against *every* type of bacteria the test says it should.
Directions for Use
What is the usual dose of Nitrofurantoin?
Adults usually take 50 to 100 milligrams of this medicine four times a day, but less might be used for simple bladder infections. Children's doses depend on their weight: 5 to 7 milligrams for every kilogram they weigh, spread out over four doses daily. Babies younger than one month shouldn't take it.
How do I take Nitrofurantoin?
Take your nitrofurantoin medicine with food to help your body absorb it better and to feel better. Don't take it with certain antacids (check the label for magnesium trisilicate). Finish all the medicine, even if you feel better, but call your doctor if anything unusual happens.
For how long do I take Nitrofurantoin?
Take the medicine for at least a week, or three days after your urine tests clean. If the infection doesn't clear up, see your doctor again. For long-term treatment, lower doses might be used for adults and children. Your doctor will tell you the correct dose.
How long does it take for Nitrofurantoin to start working?
This explains how long to take medicine for a bladder infection. You should take it for at least a week, or until three days after your urine tests clean. If you need to keep the infection away long-term, your doctor might lower your dose. Adults might take a smaller amount at night, and kids might take a very small amount once or twice a day.
How should I store Nitrofurantoin?
Keep the medicine in a cool, dry place, away from light. It's okay if the temperature changes a little, but don't let it get too hot or cold. If it's a liquid, shake it well before using and use it within a month. Don't use it if the package is damaged, and keep it away from kids. Don't freeze it.
Warnings and Precautions
Who should avoid taking Nitrofurantoin?
Nitrofurantoin is an antibiotic, but it's not safe for everyone. It can be very harmful to your kidneys, especially if they're already not working well. Pregnant women near their due date, newborns, and people with liver problems shouldn't take it. It can also cause nerve damage (especially in people with kidney problems or diabetes), lung problems (ranging from temporary coughs to permanent lung damage), and rarely, liver problems. If you have any of these issues, talk to your doctor before taking this medicine.
Can I take Nitrofurantoin with other prescription drugs?
- Nitrofurantoin may interact with some antacids, blood thinners, and other antibiotics. Always inform your doctor about all medications you take.
Can I take Nitrofurantoin with vitamins or supplements?
Multivitamins or iron supplements may interfere with Nitrofurantoin's absorption. Take Nitrofurantoin at least 2 hours apart from such supplements
Can Nitrofurantoin be taken safely while pregnant?
Nitrofurantoin is a medicine, and while tests on animals haven't shown problems at high doses, there aren't enough studies on pregnant women to know for sure it's safe. Doctors only prescribe it during pregnancy if absolutely necessary.
Can Nitrofurantoin be taken safely while breastfeeding?
Nitrofurantoin, a medicine the mother needs, shows up in breast milk in tiny amounts. Babies under one month old can have serious problems from this medicine. The doctor needs to weigh the mother's need for the medicine against the risk to the baby. They may suggest stopping breastfeeding temporarily or switching to a different medicine for the mother.
Is Nitrofurantoin safe for the elderly?
Older adults need lower doses of nitrofurantoin because their kidneys don't work as well. Doctors should check their kidney function regularly. Also, older people taking this medicine for a long time have a higher chance of serious lung or liver problems, so close monitoring is important.
Is it safe to exercise while taking Nitrofurantoin?
Yes, unless you're experiencing significant side effects like stomach upset or fatigue, you can exercise while taking Nitrofurantoin.
Is it safe to drink alcohol while taking Nitrofurantoin?
It is generally advisable to avoid alcohol while taking Nitrofurantoin due to potential stomach irritation.