Mefenamic acid
.svg)
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Possible
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Mefenamic acid
Know More About This Medicine -
Click HereSummary
Mefenamic acid is used for the relief of mild to moderate pain such as headaches, dental pain, muscle pain, and menstrual cramps. It's also used in the treatment of inflammatory conditions like arthritis and can provide short-term relief of fever in some cases.
Mefenamic acid is a pain reliever and anti-inflammatory medicine. It works by stopping the body from making substances that cause pain and swelling. It's quickly absorbed when taken orally, with its effects lasting for a couple of hours.
For adults and teens 14 and older, you start with a large dose (500mg), then take smaller doses (250mg) every six hours as needed, but only for up to a week for sudden sharp pain. For period pain, start with the large dose when your period starts and take smaller doses every six hours for two or three days.
Mefenamic acid can cause stomach upset, nausea, heartburn, and may affect sleep. It can sometimes cause headaches, skin rashes, dizziness, and swelling. Rarely, it can lead to serious effects like heart attacks, strokes, severe liver damage, and severe skin reactions.
Mefenamic acid should not be taken if you're allergic to it or similar medicines like aspirin. It can increase your chances of a heart attack, stroke or bleeding. It's risky around heart surgery and can cause stomach and intestinal problems. It should not be taken during pregnancy, especially after 20 weeks, and only small amounts can pass to a baby through breast milk.
Indications and Purpose
What is Mefenamic acid used for?
Mefenamic acid is indicated for the relief of mild to moderate pain in patients aged 14 years and older, when therapy will not exceed one week. It is also used for the treatment of primary dysmenorrhea, which is menstrual pain associated with the onset of menstruation. Always consult a healthcare provider to determine if Mefenamic acid is appropriate for your condition.
How does Mefenamic acid work?
Mefenamic acid works by inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever. By reducing prostaglandin synthesis, Mefenamic acid helps alleviate pain and inflammation.
Is Mefenamic acid effective?
Clinical trials have shown that Mefenamic acid is effective in treating primary dysmenorrhea and mild to moderate pain. In controlled, double-blind studies, it was significantly superior to placebo in reducing pain and symptoms associated with dysmenorrhea. Patients reported less need for additional analgesic medication when using Mefenamic acid.
How does one know if Mefenamic acid is working?
The benefit of Mefenamic acid is evaluated by monitoring the reduction in pain and symptoms associated with conditions like dysmenorrhea and mild to moderate pain. Patients and healthcare providers assess the effectiveness based on pain relief, the need for additional analgesics, and the improvement in daily activities. Regular follow-ups with a healthcare provider can help determine if the medication is meeting treatment goals.
Directions for Use
What is the usual dose of Mefenamic acid?
For adults and adolescents aged 14 years and older, the usual dose of Mefenamic acid for acute pain is 500 mg as an initial dose, followed by 250 mg every 6 hours as needed, usually not exceeding one week. For primary dysmenorrhea, the same dosing applies, starting with the onset of bleeding and symptoms. Mefenamic acid is not recommended for children under 14 years of age.
How do I take Mefenamic acid?
Mefenamic acid should be taken with food or milk to minimize gastrointestinal discomfort. There are no specific food restrictions, but it's advisable to avoid alcohol as it can increase the risk of stomach bleeding. Always follow your healthcare provider's instructions regarding dosage and duration of use.
For how long do I take Mefenamic acid?
Mefenamic acid is typically used for short-term relief of pain. For acute pain, the treatment duration should not exceed one week. For primary dysmenorrhea, it is usually taken for 2 to 3 days, starting with the onset of menstrual bleeding and symptoms.
How long does it take for Mefenamic acid to start working?
Mefenamic acid is rapidly absorbed after oral administration, with peak plasma levels reached in 2 to 4 hours. Patients may begin to feel relief from pain within this timeframe, although individual responses can vary. If pain persists, consult your healthcare provider for further guidance.
How should I store Mefenamic acid?
Store Mefenamic acid at room temperature, around 25°C (77°F), with permissible excursions between 15° to 30°C (59° to 86°F). Keep the medication in a tight container as defined by the USP to protect it from moisture and light. Ensure it is stored out of reach of children and pets.
Warnings and Precautions
Who should avoid taking Mefenamic acid?
Mefenamic acid carries risks of serious cardiovascular events, such as heart attack and stroke, and gastrointestinal issues like bleeding and ulcers. It's contraindicated in patients with known hypersensitivity to the drug, those with a history of asthma or allergic reactions to NSAIDs, and in the setting of coronary artery bypass graft surgery. Use the lowest effective dose for the shortest duration to minimize risks.
Can I take Mefenamic acid with other prescription drugs?
Mefenamic acid can interact with several medications, increasing the risk of adverse effects. Notable interactions include anticoagulants like warfarin, which can increase bleeding risk, and other NSAIDs or aspirin, which can heighten gastrointestinal toxicity. It may also affect the efficacy of antihypertensive drugs like ACE inhibitors and diuretics. Always inform your healthcare provider of all medications you are taking to avoid harmful interactions.
Can I take Mefenamic acid with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Mefenamic acid be taken safely while pregnant?
Mefenamic acid should be avoided during pregnancy, especially after 30 weeks, due to the risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction in the fetus. If necessary between 20 and 30 weeks, use the lowest effective dose for the shortest duration. Human studies have shown risks of fetal harm, so consult a healthcare provider for safer alternatives during pregnancy.
Can Mefenamic acid be taken safely while breastfeeding?
Trace amounts of Mefenamic acid may be present in breast milk, posing potential risks to nursing infants. Due to the possibility of serious adverse reactions in infants, a decision should be made to either discontinue nursing or the medication, considering the drug's importance to the mother. Consult a healthcare provider for personalized advice.
Is Mefenamic acid safe for the elderly?
Elderly patients are at a greater risk for serious cardiovascular, gastrointestinal, and renal adverse reactions when using Mefenamic acid. If the benefits outweigh the risks, start with the lowest effective dose and monitor for adverse effects. Due to potential decreased renal function in the elderly, careful dose selection and monitoring of renal function are advised.
Is it safe to exercise while taking Mefenamic acid?
Mefenamic acid may cause dizziness or drowsiness, which could affect your ability to exercise safely. If you experience these side effects, it might be best to avoid strenuous activities until you know how the medication affects you. Always consult your healthcare provider if you have concerns about exercising while taking this medication.
Is it safe to drink alcohol while taking Mefenamic acid?
Drinking alcohol while taking Mefenamic acid can increase the risk of gastrointestinal bleeding and ulcers. Alcohol can irritate the stomach lining, and when combined with Mefenamic acid, which also affects the stomach, the risk of adverse effects is heightened. It's advisable to limit or avoid alcohol consumption while using this medication.
Forms / Brands
