Vortioxetine

How does Vortioxetine work?

Vortioxetine inhibits serotonin reuptake and modulates serotonin receptors, enhancing its activity in the brain, which helps alleviate depressive symptoms​.

Is Vortioxetine effective?

Clinical studies confirm Vortioxetine’s effectiveness in significantly improving depression scores compared to placebo, particularly in MDD​.

What is Vortioxetine?

Vortioxetine is an antidepressant used to treat major depressive disorder (MDD) in adults. It works by enhancing serotonin activity in the brain and has additional actions on serotonin receptors, which may help relieve depressive symptom.

For how long do I take Vortioxetine?

The duration of treatment depends on the patient’s response and the healthcare provider’s recommendations. Maintenance therapy may be necessary to prevent depressive relapses​.

How do I take Vortioxetine?

Take your Vortioxetine once a day. It doesn't matter if you take it with or without food.

How long does it take for Vortioxetine to start working?

Some improvement in depressive symptoms may be observed within 2 weeks, with full effects typically seen by 4 to 8 weeks​.

How should I store Vortioxetine?

Store at 25°C (77°F) with acceptable excursions to 15°C-30°C (59°F-86°F)​.

What is the usual dose of Vortioxetine?

For grown-ups, the usual highest dose is 20mg a day. However, some people need a lower dose (10mg) depending on their body's ability to process the medicine or other medications they're taking. In some rare cases, a doctor might increase the dose, but never more than three times the starting amount. 

Can I take Vortioxetine with other prescription drugs?

Vortioxetine shouldn't be taken with certain other medicines. It's especially dangerous to combine it with MAOIs (a type of antidepressant) – you need to wait at least 21 days after stopping Trintellix before starting an MAOI, and 14 days after stopping an MAOI before starting Vortioxetine. Also avoid linezolid and intravenous methylene blue. Taking Trintellix with blood thinners like aspirin, NSAIDs, or warfarin increases your risk of bleeding. Finally, combining it with some other drugs (like other antidepressants, pain relievers, certain supplements, and St. John's Wort) raises the chance of a serious reaction called serotonin syndrome. 

Can Vortioxetine be taken safely while breastfeeding?

It's not known if the medicine Vortioxetine passes into breast milk. Studies in rats showed a high dose of the medicine's active ingredient did appear in their milk, but the amount changed over time. Because of this uncertainty, you should talk to your doctor about the safest way to feed your baby while taking Vortioxetine. 

Can Vortioxetine be taken safely while pregnant?

Taking Trintellix while pregnant might hurt the baby. There's a slightly higher chance of heavy bleeding after delivery if you take this type of medicine near the end of pregnancy. Doctors are keeping track of how Trintellix affects babies born to mothers who took it.  

Is it safe to drink alcohol while taking Vortioxetine?

Alcohol may enhance certain side effects like dizziness. Limit alcohol consumption while on Vortioxetine​.

Is it safe to exercise while taking Vortioxetine?

Exercise is safe but monitor for dizziness or nausea, especially during intense activities​.

Is Vortioxetine safe for the elderly?

This medicine works the same way in older adults as it does in younger adults, and it's just as safe. However, older people have a slightly higher chance of developing low sodium levels in their blood (hyponatremia) while taking it.

Who should avoid taking Vortioxetine?

• Patients with MAOI use within 14 days.
• Individuals allergic to Vortioxetine or its components.
• Those at risk of serotonin syndrome​