Valbenazine
Tardive Dyskinesia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Vesicular Monoamine Transporter 2 Inhibitor
Controlled Drug Substance
No
valbenazine
Summary
Valbenazine is used to treat tardive dyskinesia, which is a movement disorder caused by long-term use of certain medications. It helps reduce involuntary movements, such as facial grimacing or tongue movements, improving quality of life for those affected.
Valbenazine works by inhibiting VMAT2, which is a protein that helps regulate dopamine, a brain chemical involved in movement. By reducing dopamine activity, Valbenazine helps decrease involuntary movements associated with tardive dyskinesia.
The usual starting dose of Valbenazine for adults is 40 mg once daily. Your doctor may increase the dose to 80 mg daily based on your response and tolerance. It is taken orally, usually once a day, with or without food.
Common side effects of Valbenazine include drowsiness, dry mouth, and fatigue. These effects are usually mild and occur in a small percentage of people. If you notice new symptoms, they might be temporary or unrelated to the medication.
Valbenazine can cause drowsiness, affecting your ability to drive. It may also cause QT prolongation, which is a heart rhythm condition. It should not be used if you have a known allergy to it or its ingredients, or if you have congenital long QT syndrome.
Indications and Purpose
How does Valbenazine work?
Valbenazine works by inhibiting VMAT2, which is a protein that helps regulate dopamine, a brain chemical involved in movement. By reducing dopamine activity, Valbenazine helps decrease involuntary movements associated with tardive dyskinesia. Think of it like adjusting the volume on a radio to reduce noise. This action helps improve movement control and quality of life for those with the disorder.
Is Valbenazine effective?
Valbenazine is effective in treating tardive dyskinesia, which is a movement disorder caused by long-term use of certain medications. Clinical studies show that Valbenazine significantly reduces involuntary movements in patients with tardive dyskinesia. The medication works by affecting certain chemicals in the brain that control movement. Most patients experience noticeable improvement in symptoms with regular use.
What is Valbenazine?
Valbenazine is a medication used to treat tardive dyskinesia, which is a movement disorder caused by long-term use of certain medications. It belongs to a class of drugs called VMAT2 inhibitors, which work by affecting chemicals in the brain that control movement. Valbenazine helps reduce involuntary movements, such as facial grimacing or tongue movements, improving quality of life for those affected.
Directions for Use
For how long do I take Valbenazine?
Valbenazine is usually a long-term treatment for managing tardive dyskinesia, which is a movement disorder. You'll typically take it every day as a continuous treatment unless your doctor suggests otherwise. The duration of use depends on your response to the medication and any side effects you experience. Always follow your doctor's advice regarding the length of treatment with Valbenazine.
How do I dispose of Valbenazine?
Dispose of Valbenazine by taking it to a drug take-back program or collection site at a pharmacy or hospital. If these options are not available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and then throw it away. This helps prevent accidental ingestion or harm to the environment.
How do I take Valbenazine?
Take Valbenazine as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember, unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. There are no specific dietary restrictions, but always follow your doctor's advice regarding food and drink while on this medication.
How long does it take for Valbenazine to start working?
Valbenazine may start to show effects within a week, but it can take several weeks to achieve its full therapeutic effect. The time it takes to work can vary based on individual factors, such as your overall health and how your body responds to the medication. Regular follow-ups with your doctor are important to monitor progress and make any necessary adjustments to your treatment.
How should I store Valbenazine?
Store Valbenazine at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Keep it out of reach of children and pets. Check the expiration date regularly and dispose of any unused or expired medication properly. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Valbenazine?
The usual starting dose of Valbenazine for adults is 40 mg once daily. Your doctor may increase the dose to 80 mg daily based on your response and tolerance. There are no specific dosing instructions for children, as Valbenazine is typically prescribed for adults. Elderly patients may require careful monitoring. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can I take Valbenazine with other prescription drugs?
Valbenazine can interact with medications that affect heart rhythm, such as certain antipsychotics and antibiotics. These interactions can increase the risk of QT prolongation, which is a heart rhythm disorder. Always inform your doctor of all medications you are taking to prevent potential interactions. Your doctor can help adjust your treatment plan to ensure safety and effectiveness.
Can Valbenazine be taken safely while breastfeeding?
The safety of Valbenazine while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you are breastfeeding or planning to breastfeed, talk with your doctor. They can help weigh the potential risks and benefits and suggest safer alternatives if necessary. Always follow your doctor's advice regarding medication use while breastfeeding.
Can Valbenazine be taken safely while pregnant?
The safety of Valbenazine during pregnancy is not well-established. There is limited information on its effects on pregnant women. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your doctor. They can help determine the safest treatment options for you and your baby. Always follow your doctor's advice regarding medication use during pregnancy.
Does Valbenazine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Valbenazine include drowsiness, dry mouth, and fatigue. These effects are usually mild. Serious side effects, like QT prolongation, are rare but require immediate medical attention. If you experience any new or worsening symptoms, contact your doctor. They can help determine if the symptoms are related to Valbenazine and suggest appropriate actions.
Does Valbenazine have any safety warnings?
Valbenazine has important safety warnings. It can cause drowsiness, which may affect your ability to drive or operate machinery. It may also cause QT prolongation, which is a heart rhythm condition that can lead to serious complications. If you experience symptoms like dizziness, fainting, or irregular heartbeat, seek medical help immediately. Always follow your doctor's advice and report any unusual symptoms while taking Valbenazine.
Is it safe to drink alcohol while taking Valbenazine?
It's best to avoid alcohol while taking Valbenazine. Alcohol can increase the risk of side effects like drowsiness and dizziness. These effects can impair your ability to perform tasks that require alertness, such as driving. If you choose to drink, do so in moderation and be aware of how your body responds. Always discuss alcohol use with your doctor to get personalized advice.
Is it safe to exercise while taking Valbenazine?
You can exercise while taking Valbenazine, but be mindful of how your body feels. Valbenazine can cause drowsiness or dizziness, which might affect your exercise capacity. If you feel dizzy or lightheaded, take a break and rest. Stay hydrated and avoid strenuous activities until you know how the medication affects you. Consult your doctor if you have concerns about exercising while on Valbenazine.
Is it safe to stop Valbenazine?
It's important not to stop Valbenazine suddenly without consulting your doctor. Stopping abruptly can lead to a return of symptoms. Your doctor may suggest gradually reducing the dose to prevent any potential withdrawal effects. Always follow your doctor's guidance when making changes to your medication regimen to ensure your health condition remains stable.
Is Valbenazine addictive?
Valbenazine is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Valbenazine works by affecting certain chemicals in the brain but does not alter brain chemistry in a way that leads to addiction. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance on managing your treatment.
Is Valbenazine safe for the elderly?
Elderly patients may be more sensitive to the side effects of Valbenazine, such as drowsiness or dizziness. These effects can increase the risk of falls. It's important for elderly patients to be closely monitored by their doctor while taking Valbenazine. Dose adjustments may be necessary based on individual tolerance and response. Always follow your doctor's advice regarding medication use in older adults.
What are the most common side effects of Valbenazine?
Side effects are unwanted reactions to a medication. Common side effects of Valbenazine include drowsiness, dry mouth, and fatigue. These occur in a small percentage of people. If you notice new symptoms after starting Valbenazine, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Valbenazine.
Who should avoid taking Valbenazine?
Valbenazine should not be used if you have a known allergy to it or its ingredients. It is also contraindicated in patients with congenital long QT syndrome, which is a heart rhythm disorder. Caution is needed if you have a history of heart problems or are taking medications that affect heart rhythm. Always inform your doctor of your medical history before starting Valbenazine.
