Trimipramine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Tricyclic Antidepressant
Controlled Drug Substance
No
Trimipramine
Summary
Trimipramine is used to treat depression, especially endogenous depression. It's also used when depression is accompanied by sleep disturbances, anxiety, or agitation.
Trimipramine works by increasing the levels of certain natural substances in the brain. These substances help maintain mental balance and alleviate symptoms of depression. It belongs to the class of tricyclic antidepressants and has sedative effects.
For adults, the usual initial dose of Trimipramine is 50-75 mg per day. This can be increased to 150-300 mg per day in divided doses or as a single dose at night. The maintenance dose is typically 75-150 mg per day.
Common side effects of Trimipramine include drowsiness, dry mouth, constipation, changes in appetite, and changes in sex drive or ability. It can also cause mood changes, difficulty sleeping, headaches, stomach pain, and weight changes.
Trimipramine should not be taken with MAO inhibitors due to the risk of serotonin syndrome. It's also contraindicated during breastfeeding and should be used cautiously during pregnancy. It may cause drowsiness and dizziness, affecting your ability to drive or operate machinery. It carries a risk of increasing suicidal thoughts, especially in young people.
Indications and Purpose
How does Trimipramine work?
Trimipramine works by increasing the levels of certain natural substances in the brain, which help maintain mental balance and alleviate symptoms of depression. It belongs to the class of tricyclic antidepressants and has sedative effects.
Is Trimipramine effective?
Trimipramine is a tricyclic antidepressant used to treat depression by increasing certain natural substances in the brain to maintain mental balance. Clinical studies have shown it to be effective in relieving symptoms of depression, particularly endogenous depression.
What is Trimipramine?
Trimipramine is a tricyclic antidepressant used to treat depression by increasing certain natural substances in the brain to maintain mental balance. It is particularly effective for endogenous depression and has sedative properties that can help with sleep disturbances.
Directions for Use
For how long do I take Trimipramine?
Trimipramine is typically used for several weeks to months, depending on the individual's response and the doctor's recommendation. It may take up to 4 weeks to feel the full benefit, and maintenance therapy can continue for about three months after remission.
How do I take Trimipramine?
Trimipramine should be taken exactly as prescribed by your doctor, usually one to three times a day. It can be taken with or without food, and there are no specific food restrictions. However, avoid alcohol as it can increase drowsiness.
How long does it take for Trimipramine to start working?
It may take up to 4 weeks before you feel the full benefit of Trimipramine. Continue taking the medication as directed by your doctor, even if you start feeling better.
How should I store Trimipramine?
Store Trimipramine in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and dispose of it properly through a take-back program if no longer needed.
What is the usual dose of Trimipramine?
For adults, the usual dose of Trimipramine is 50-75 mg per day initially, which can be increased to 150-300 mg per day in divided doses or as a single dose at night. The maintenance dose is typically 75-150 mg per day. Trimipramine is not recommended for children.
Warnings and Precautions
Can I take Trimipramine with other prescription drugs?
Trimipramine should not be taken with MAO inhibitors due to the risk of serotonin syndrome. It may interact with cimetidine, increasing its effects, and should be used cautiously with other serotonergic drugs and those affecting heart rhythm.
Can Trimipramine be taken safely while breastfeeding?
Trimipramine is contraindicated during breastfeeding as it may pass into breast milk and affect the nursing infant. Consult your doctor for alternative treatments if you are breastfeeding.
Can Trimipramine be taken safely while pregnant?
Trimipramine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is no adequate and well-controlled study in pregnant women, so it is important to consult a healthcare provider for personalized advice.
Is it safe to drink alcohol while taking Trimipramine?
Drinking alcohol while taking Trimipramine can increase the drowsiness caused by the medication. It is advised to avoid alcohol to prevent enhanced sedative effects and potential impairment.
Is it safe to exercise while taking Trimipramine?
Trimipramine may cause drowsiness and dizziness, which could affect your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. Consult your doctor if you have concerns about exercising while on Trimipramine.
Is Trimipramine safe for the elderly?
Elderly patients should use Trimipramine with caution, as they may be more sensitive to its effects, such as confusion and sedation. A lower starting dose is recommended, and any dosage increases should be made cautiously under close supervision.
Who should avoid taking Trimipramine?
Trimipramine carries a risk of increasing suicidal thoughts, especially in young people. It should not be used with MAO inhibitors or in patients with recent heart attacks. Caution is advised for those with glaucoma, urinary retention, or a history of seizures.
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