Trifluridine
Herpetic Keratitis , Infectious Keratoconjunctivitis
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Nucleoside Analog Antiviral and Nucleoside Metabolic Inhibitor
Controlled Drug Substance
No
Summary
Trifluridine is used to treat eye infections caused by the herpes simplex virus, which is a virus that can cause sores and infections in the eyes. It helps reduce symptoms like redness, pain, and swelling in the affected eye.
Trifluridine works by inhibiting the replication of the herpes simplex virus, which means it stops the virus from multiplying. This action helps to clear the infection and reduce symptoms like redness, pain, and swelling.
Trifluridine is usually applied as an eye drop. The typical dose for adults is one drop in the affected eye every 2 hours while awake, up to 9 times a day. Once the ulcer has healed, the frequency is reduced to one drop every 4 hours while awake, up to 5 times a day.
Common side effects of trifluridine include mild eye irritation, burning, or stinging, which are usually temporary. Serious adverse effects are rare but can include severe eye irritation or vision changes. If you notice any new or worsening symptoms, contact your doctor.
Trifluridine should not be used for longer than prescribed, as prolonged use can lead to eye irritation or other complications. If you experience severe eye irritation, swelling, or vision changes, contact your doctor immediately. Do not use trifluridine if you're allergic to it or any of its ingredients.
Indications and Purpose
How does trifluridine work?
Trifluridine works by inhibiting the replication of the herpes simplex virus in the eye. It belongs to a class of drugs called nucleoside analogs, which interfere with the virus's DNA synthesis. Think of it like a roadblock that prevents the virus from multiplying and spreading. This action helps to clear the infection and reduce symptoms like redness, pain, and swelling.
Is trifluridine effective?
Trifluridine is effective in treating eye infections caused by the herpes simplex virus. It works by inhibiting the virus's ability to replicate, helping to clear the infection. Clinical studies support its effectiveness in reducing symptoms and healing the infection. For best results, use trifluridine exactly as prescribed by your doctor.
What is trifluridine?
Trifluridine is an antiviral medication used to treat eye infections caused by the herpes simplex virus. It belongs to a class of drugs called nucleoside analogs, which work by inhibiting the virus's ability to replicate. This helps to clear the infection and reduce symptoms like redness, pain, and swelling in the eye. Trifluridine is applied as an eye drop and is used for short-term treatment.
Directions for Use
For how long do I take trifluridine?
Trifluridine is usually used for short-term treatment of eye infections. The typical duration is until the infection is healed, as directed by your doctor. It's important to complete the full course of treatment to ensure the infection is fully treated. Always follow your doctor's instructions regarding the duration of use for trifluridine.
How do I dispose of trifluridine?
To dispose of trifluridine, bring unused medicine to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take trifluridine?
Trifluridine is usually applied as an eye drop. You should use it as directed by your doctor, typically every 2 hours while awake, up to 9 times a day. It's important not to miss doses for the best effect. If you miss a dose, apply it as soon as you remember unless it's almost time for your next dose. Then, skip the missed dose and continue your regular schedule. Do not double up on doses.
How long does it take for trifluridine to start working?
Trifluridine starts working shortly after you begin using it, with noticeable improvement in symptoms like redness and pain within a few days. The full therapeutic effect may take up to 14 days, depending on the severity of the infection. It's important to use trifluridine exactly as prescribed and complete the full course of treatment for the best results.
How should I store trifluridine?
Store trifluridine at room temperature, away from light and moisture. Keep the bottle tightly closed when not in use. Do not store it in the bathroom, where humidity can affect the medication. Always keep trifluridine out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of trifluridine?
The usual dose of trifluridine for adults is one drop in the affected eye every 2 hours while awake, up to 9 times a day. Once the ulcer has healed, the frequency is reduced to one drop every 4 hours while awake, up to 5 times a day, for an additional 7 days. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take trifluridine with other prescription drugs?
Trifluridine is an eye drop and doesn't have significant interactions with other prescription drugs. However, it's always important to inform your doctor about all the medications you're taking to ensure there are no potential interactions. Your doctor can provide personalized advice based on your specific health needs.
Can trifluridine be taken safely while breastfeeding?
The safety of trifluridine while breastfeeding is not well-established. It's unclear if this medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest options for managing your condition. Your doctor can help determine if trifluridine is appropriate for you or suggest alternative treatments.
Can trifluridine be taken safely while pregnant?
The safety of trifluridine during pregnancy is not well-established. Limited data is available, so it's important to weigh the potential benefits against the risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Does trifluridine have adverse effects?
Adverse effects are unwanted reactions to a medication. With trifluridine, common adverse effects include mild eye irritation or burning. These effects are usually temporary. Serious adverse effects are rare but can include severe eye irritation or vision changes. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to trifluridine and suggest appropriate actions.
Does trifluridine have any safety warnings?
Trifluridine has important safety warnings. It should not be used for longer than prescribed, as prolonged use can lead to eye irritation or other complications. If you experience severe eye irritation, swelling, or vision changes, contact your doctor immediately. It's important to follow your doctor's instructions and not to use the medication more frequently than recommended.
Is it safe to drink alcohol while taking trifluridine?
There are no well-established interactions between trifluridine and alcohol. However, it's always a good idea to limit alcohol consumption while taking any medication. Alcohol can affect your overall health and may interfere with your body's ability to fight infections. Talk with your doctor about alcohol use while taking trifluridine to get personalized advice.
Is it safe to exercise while taking trifluridine?
You can exercise while using trifluridine. This medication is an eye drop and doesn't typically affect your ability to exercise. However, if you experience any unusual symptoms like dizziness or fatigue, slow down or stop exercising and rest. If you have concerns about your specific situation, talk with your doctor.
Is it safe to stop trifluridine?
Trifluridine is usually used for a short-term treatment of eye infections. It's important to complete the full course as prescribed by your doctor, even if symptoms improve, to ensure the infection is fully treated. Stopping the medication too soon may result in the infection returning. Always talk with your doctor before stopping trifluridine to ensure it's safe to do so.
Is trifluridine addictive?
Trifluridine is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop using it. It works locally in the eye and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to use more than prescribed.
Is trifluridine safe for the elderly?
The elderly may be more vulnerable to side effects from medications due to age-related changes in the body. Trifluridine is generally safe for elderly patients, but they should be monitored for any adverse effects like eye irritation. If you have concerns about using trifluridine, talk with your doctor for personalized advice.
What are the most common side effects of trifluridine?
Side effects are unwanted reactions that can happen when taking a medication. With trifluridine, common side effects include mild eye irritation, burning, or stinging. These effects are usually temporary and may go away as your body adjusts to the medication. If you notice new symptoms after starting trifluridine, they might be temporary or unrelated to the medication. Talk with your doctor if you have concerns.
Who should avoid taking trifluridine?
Don't use trifluridine if you're allergic to it or any of its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. If you have any concerns about allergies or other contraindications, consult your doctor before using trifluridine.
