Triamterene
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Potassium-sparing Diuretic
Controlled Drug Substance
NO
Triamterene
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Click HereSummary
Triamterene is used to treat edema, or swelling, associated with conditions like congestive heart failure, liver cirrhosis, and nephrotic syndrome. It can also be used for conditions like steroid-induced edema and secondary hyperaldosteronism.
Triamterene works by inhibiting sodium reabsorption in the kidneys. This leads to increased excretion of water and sodium, while conserving potassium. This helps reduce fluid retention and swelling.
The usual starting dose for adults is 100 mg twice daily after meals. The total daily dosage should not exceed 300 mg. Always follow your doctor's advice for dosage.
Common side effects include dizziness, headache, nausea, and vomiting. Serious adverse effects can include hyperkalemia, muscle weakness, and irregular heartbeat.
Triamterene should not be used with other potassium-sparing agents or in patients with elevated serum potassium. It can cause hyperkalemia, especially in patients with renal impairment or diabetes. Regular monitoring of potassium levels is crucial.
Indications and Purpose
How does one know if Triamterene is working?
The benefit of Triamterene is evaluated through regular monitoring of symptoms and laboratory tests, such as serum potassium levels, to ensure the medication is effectively managing the condition without causing adverse effects.
How does Triamterene work?
Triamterene acts by inhibiting sodium reabsorption in the distal tubules of the kidneys. This leads to increased excretion of water and sodium while conserving potassium, helping to reduce fluid retention and swelling.
Is Triamterene effective?
Triamterene is effective in treating edema associated with conditions like congestive heart failure and liver cirrhosis. It works by inhibiting sodium reabsorption in the kidneys, promoting diuresis while conserving potassium.
What is Triamterene?
Triamterene is a diuretic used to treat edema associated with conditions like heart failure and liver cirrhosis. It works by inhibiting sodium reabsorption in the kidneys, promoting water excretion while conserving potassium. This helps reduce fluid retention and swelling.
What is Triamterene used for?
Triamterene is indicated for treating edema associated with congestive heart failure, liver cirrhosis, nephrotic syndrome, and conditions like steroid-induced edema and secondary hyperaldosteronism.
Directions for Use
For how long do I take Triamterene?
Triamterene is typically used until the condition it is prescribed for is managed or as directed by a healthcare provider. The duration can vary based on individual needs and response to treatment.
How do I take Triamterene?
Triamterene should be taken after meals to help avoid stomach upset. Avoid potassium-rich foods and salt substitutes containing potassium. Follow your doctor's dietary recommendations, including any advice on a reduced sodium diet.
How long does it take for Triamterene to start working?
Triamterene typically starts working within 2 to 4 hours after ingestion. However, the maximum therapeutic effect may not be seen for several days.
How should I store Triamterene?
Store Triamterene in a tightly closed container at room temperature, away from excess heat and moisture. Keep it out of reach of children and do not store it in the bathroom.
What is the usual dose of Triamterene?
The usual starting dose for adults is 100 mg twice daily after meals. The total daily dosage should not exceed 300 mg. Safety and effectiveness in pediatric patients have not been established. Always follow your doctor's advice for dosage.
Warnings and Precautions
Can I take Triamterene with other prescription drugs?
Triamterene should not be used with other potassium-sparing agents like spironolactone or amiloride. It may interact with NSAIDs, ACE inhibitors, and lithium, potentially leading to serious side effects like hyperkalemia or lithium toxicity.
Can I take Triamterene with vitamins or supplements?
Avoid potassium supplements or potassium-containing salt substitutes while taking Triamterene, as they can increase the risk of hyperkalemia. Consult your doctor before taking any new vitamins or supplements.
Can Triamterene be taken safely while breastfeeding?
Triamterene appears in animal milk and is likely present in human milk. If the drug is deemed essential, breastfeeding should be discontinued. Consult a healthcare provider for personalized advice.
Can Triamterene be taken safely while pregnant?
Triamterene should be used during pregnancy only if clearly needed, as it crosses the placental barrier. The potential benefits must be weighed against possible risks to the fetus. Consult a healthcare provider for personalized advice.
Is Triamterene safe for the elderly?
Elderly patients may be more susceptible to the side effects of Triamterene, particularly hyperkalemia. Regular monitoring of serum potassium levels is recommended. Consult a healthcare provider for personalized advice.
Who should avoid taking Triamterene?
Triamterene can cause hyperkalemia, especially in patients with renal impairment or diabetes. It should not be used with other potassium-sparing agents or in patients with elevated serum potassium. Regular monitoring of potassium levels is crucial.
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