Tizanidine

Low Back Pain, Muscle Cramp ... show more

Drug Status

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Government Approvals

US(FDA), UK(BNF)

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WHO Essential Medicine

NO

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Known Teratogen

NO

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Pharmaceutical Class

Central alpha-2 Adrenergic Agonist

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Controlled Drug Substance

NO

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Drug Ingredient

Tizanidine

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Summary

  • Tizanidine is used to treat muscle spasticity, a condition that causes muscle stiffness and tightness. It's often prescribed for conditions like multiple sclerosis, spinal cord injuries, and other neurological disorders that cause muscle spasms.

  • Tizanidine works by blocking nerve impulses or pain signals sent to the brain. It acts on the central nervous system, specifically targeting alpha2 adrenergic receptors in the spinal cord. This leads to a reduction in muscle tone and spasticity, which results in muscle relaxation and a decrease in pain or discomfort.

  • Tizanidine is typically taken by mouth, with or without food, as directed by your doctor. The starting dose is usually 2 mg once a day, with adjustments made every 3-4 days. The maximum dose is 36 mg per day. Always follow your doctor's instructions closely.

  • Tizanidine may cause side effects like drowsiness, dizziness, low blood pressure, dry mouth, and fatigue. In some cases, it can also cause liver issues. If you stop taking Tizanidine suddenly, you may experience withdrawal symptoms like increased muscle spasticity, high blood pressure, and a faster heart rate.

  • Tizanidine should be avoided by individuals with liver disease, low blood pressure, or a history of allergic reactions to it. It's also not recommended for those taking certain medications like fluvoxamine, ciprofloxacin, or other sedatives. If you're pregnant, breastfeeding, or trying to conceive, consult with your healthcare provider before taking Tizanidine.

Indications and Purpose

How does one know if Tizanidine is working?

You can tell if Tizanidine is working if you experience a reduction in muscle spasticity or stiffness, along with improved mobility and comfort. For example, you may notice less muscle tightness, fewer spasms, and an improved range of motion. You may also feel less discomfort in the muscles that were previously affected. If these changes occur after taking the medication, it indicates that Tizanidine is having a positive effect. However, if you don’t experience improvement or if side effects outweigh the benefits, consult your doctor for further evaluation.

How does Tizanidine work?

Tizanidine works by blocking nerve impulses (or pain signals) sent to the brain. It is a muscle relaxant that acts on the central nervous system, specifically by targeting alpha-2 adrenergic receptors in the spinal cord. This reduces muscle tone and spasticity, leading to muscle relaxation and a decrease in pain or discomfort.

Is Tizanidine effective?

Yes, Tizanidine is effective for managing muscle spasticity and certain types of muscle pain. It works by reducing muscle tone, which helps alleviate discomfort and improves mobility. It's often used for conditions such as multiple sclerosis, spinal cord injury, and other neurological disorders that cause muscle spasms. However, its effectiveness can vary depending on the individual and the severity of the condition being treated.

What is Tizanidine?

Tizanidine is a medication that is used to treat muscle spasticity. It works by relaxing the muscles and reducing muscle tone. Tizanidine is commonly prescribed to people with conditions like multiple sclerosis, spinal cord injuries, or certain neurological disorders that cause muscle spasms. It belongs to a class of drugs called alpha-2 adrenergic agonists.

What is Tizanidine used for?

Tizanidine is used to treat muscle spasticity, which can result from conditions like multiple sclerosis, spinal cord injuries, or other neurological disorders. It helps relax muscles and relieve tightness or stiffness.

Directions for Use

For how long do I take Tizanidine?

Tizanidine helps relax stiff muscles, but its effect doesn't last long. So, it's best to take it only when you really need the muscle relaxation, not all the time.

How do I take Tizanidine?

Tizanidine is usually taken by mouth with or without food, as directed by your doctor. It’s typically taken once a day, with doses spread out. Follow your doctor’s instructions closely and avoid taking more than prescribed.

How long does it take for Tizanidine to start working?

Tizanidine usually starts working within 1 to 2 hours after taking it. However, the full effects may take a few days to become noticeable as your body adjusts.

How should I store Tizanidine?

To store Tizanidine:

  1. Keep it at room temperature: Store it in a cool, dry place away from heat and moisture.
  2. Avoid exposure to light: Keep the medication in its original container, tightly closed.
  3. Keep out of reach of children: Ensure it is stored in a secure location to prevent accidental ingestion.

Do not store Tizanidine in the bathroom or near a sink, as humidity can affect its effectiveness.

What is the usual dose of Tizanidine?

This medicine, tizanidine, starts at a low dose (2mg) taken every 6 to 8 hours, up to three times a day. The most you should take in a whole day is 36mg, but don't take more than 16mg at once. Your doctor will slowly increase your dose if needed. It's not meant for children.

Warnings and Precautions

Can I take Tizanidine with other prescription drugs?

Tizanidine can interact with several prescription drugs, especially those that affect the central nervous system, such as sedatives, antidepressants, and anti-anxiety medications. It may also interact with medications that affect the liver, such as fluvoxamine or ciprofloxacin. Always consult with your healthcare provider before combining Tizanidine with other prescription drugs to avoid potential interactions.

Can I take Tizanidine with vitamins or supplements?

Tizanidine may interact with certain vitamins or supplements, particularly those that affect the liver or have sedative effects. Always check with your healthcare provider before combining Tizanidine with vitamins or supplements to ensure safety.

Can Tizanidine be taken safely while breastfeeding?

Tizanidine should be used with caution while breastfeeding, as it can pass into breast milk and may affect the infant. It is generally recommended to avoid taking Tizanidine while breastfeeding, unless the benefits to the mother outweigh the potential risks to the baby. Always consult your healthcare provider for personalized advice if you are breastfeeding and considering taking Tizanidine.

Can Tizanidine be taken safely while pregnant?

Tizanidine should generally be avoided during pregnancy unless deemed absolutely necessary by your healthcare provider. It is classified as a pregnancy category C drug, which means that it may cause harm to a developing fetus, but potential benefits may outweigh the risks in some cases. Always consult your doctor before taking Tizanidine if you are pregnant or planning to become pregnant.

Is it safe to drink alcohol while taking Tizanidine?

Mixing alcohol and tizanidine is risky because they both slow down your brain and nervous system. Taking them together makes this effect stronger, meaning you're more likely to feel sleepy, dizzy, or have other unpleasant side effects. Basically, the alcohol makes the tizanidine more powerful, increasing the chances of problems.

Is it safe to exercise while taking Tizanidine?

Tizanidine can make you feel sleepy and drowsy. This might make it hard to exercise safely, especially if the activity needs you to be alert and focused. Doctors don't know exactly how it affects really hard workouts, so be careful.

Is Tizanidine safe for the elderly?

Older people might process tizanidine more slowly than younger people. This means they need smaller doses to start, and those doses should be increased gradually. Because older adults' kidneys might not work as well, they're more likely to have side effects. It's important to check how well their kidneys are working and adjust the medicine dose as needed. If a higher dose is necessary, increase the amount of medicine per dose, not how often they take it.

Who should avoid taking Tizanidine?

Tizanidine should be avoided by individuals with liver disease, low blood pressure, or a history of allergic reactions to it. It's also not recommended for those taking certain medications like fluvoxamine, ciprofloxacin, or other sedatives. Always consult your doctor before use.