Tiagabine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Anti-epileptic Agent
Controlled Drug Substance
No
Tiagabine
Summary
Tiagabine is primarily used as an additional treatment for partial seizures in adults and children over 12 years old who have epilepsy.
Tiagabine works by increasing the availability of gammaaminobutyric acid (GABA), an inhibitory neurotransmitter in the brain. This helps to prevent seizure activity.
The usual maintenance dose of Tiagabine is 30-45 mg per day for those taking enzyme-inducing drugs, and 15-30 mg per day for those not taking enzyme-inducing drugs. It's taken orally, usually alongside other antiepileptic medications.
Common side effects of Tiagabine include dizziness, drowsiness, lack of energy, nausea, and difficulty concentrating. Serious adverse effects can include seizures in non-epileptic patients, suicidal thoughts, and severe rash.
Tiagabine may cause seizures in people without epilepsy and increase the risk of suicidal thoughts or behavior. It should not be used in patients with hypersensitivity to the drug or its ingredients. It should not be stopped abruptly and caution is advised in patients with liver impairment.
Indications and Purpose
How does Tiagabine work?
Tiagabine works by increasing the levels of a neurotransmitter called GABA in the brain, which helps calm nerve activity and reduce seizures. Think of it like turning down the volume on a loudspeaker. By enhancing GABA's effects, Tiagabine helps control seizures in people with epilepsy. This medication is usually used in combination with other seizure medications to enhance its effectiveness.
Is Tiagabine effective?
Tiagabine is effective for treating partial seizures in epilepsy. It works by increasing the levels of a neurotransmitter called GABA, which helps calm nerve activity in the brain. Clinical studies show Tiagabine reduces seizure frequency in people with epilepsy. Always follow your doctor's instructions and attend regular check-ups to monitor the effectiveness of your treatment.
What is Tiagabine?
Tiagabine is a medication used to treat partial seizures in epilepsy. It belongs to a class of drugs called anticonvulsants, which help control seizures by increasing the levels of a neurotransmitter called GABA in the brain. This action helps calm nerve activity and reduce seizure frequency. Tiagabine is usually used in combination with other seizure medications to enhance its effectiveness.
Directions for Use
For how long do I take Tiagabine?
Tiagabine is usually a long-term medication for managing epilepsy. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Tiagabine treatment.
How do I dispose of Tiagabine?
Dispose of Tiagabine by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Tiagabine?
Take Tiagabine exactly as your doctor prescribes. It's usually taken once or twice daily, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Tiagabine to start working?
Tiagabine begins working in your body shortly after you take it, but it may take several weeks to achieve its full therapeutic effect. The time it takes to notice improvements can vary based on individual factors like your condition and response to the medication. Always take Tiagabine exactly as prescribed and attend regular check-ups with your doctor to monitor your progress.
How should I store Tiagabine?
Store Tiagabine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store your medicine in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store Tiagabine out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Tiagabine?
The usual starting dose of Tiagabine for adults is 4 mg once daily, usually in the evening. Your doctor may gradually increase your dose based on your response and needs. The maximum recommended dose is 56 mg per day. Always follow your doctor's specific dosing instructions. Dose adjustments may be necessary for special populations, such as the elderly or those with liver problems.
Warnings and Precautions
Can I take Tiagabine with other prescription drugs?
Tiagabine's effectiveness can be affected by drugs that induce hepatic enzymes, such as carbamazepine, phenytoin, phenobarbital, and primidone, which can increase its metabolism and reduce its plasma levels. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions and ensure optimal dosing of Tiagabine.
Can Tiagabine be taken safely while breastfeeding?
The safety of Tiagabine while breastfeeding isn't well-established. It's unclear if Tiagabine passes into breast milk or affects the breastfed infant. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can Tiagabine be taken safely while pregnant?
The safety of Tiagabine during pregnancy isn't well-established. Limited data is available, and the effects on the unborn baby are not fully known. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Does Tiagabine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Tiagabine include dizziness, tiredness, and difficulty concentrating. These effects vary in frequency and severity. Serious side effects can include seizures in people without epilepsy. If you experience any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Tiagabine and suggest appropriate actions.
Does Tiagabine have any safety warnings?
Yes, Tiagabine has important safety warnings. It can cause seizures in people without epilepsy, especially if used off-label. This medication may also cause dizziness or drowsiness, affecting your ability to drive or operate machinery. Not adhering to these warnings can lead to serious consequences, such as increased seizure risk or accidents. Always follow your doctor's instructions and report any unusual symptoms.
Is it safe to drink alcohol while taking Tiagabine?
It's best to avoid alcohol while taking Tiagabine. Alcohol can increase the risk of side effects like dizziness or drowsiness, which may affect your ability to drive or operate machinery. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like increased dizziness or drowsiness. Talk with your doctor about alcohol use while taking Tiagabine.
Is it safe to exercise while taking Tiagabine?
You can exercise while taking Tiagabine, but be cautious. This medication can cause dizziness or drowsiness, which might affect your balance or coordination during physical activity. To exercise safely, start with light activities and gradually increase intensity. If you feel dizzy or lightheaded, stop exercising and rest. Talk with your doctor if you have concerns about your specific situation.
Is it safe to stop Tiagabine?
Stopping Tiagabine suddenly can cause serious problems, especially if you're taking it for epilepsy. It may lead to increased seizure frequency or severity. Always talk with your doctor before stopping Tiagabine. They might suggest gradually reducing your dose to prevent withdrawal symptoms and keep your condition under control. Your doctor will help you make any medication changes safely.
Is Tiagabine addictive?
Tiagabine is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Tiagabine works by affecting neurotransmitters in the brain to help control seizures. This mechanism doesn't lead to addiction. If you have concerns about medication dependence, discuss them with your doctor, but Tiagabine doesn't carry this risk.
Is Tiagabine safe for the elderly?
There is limited information on the use of Tiagabine in elderly patients. However, since the pharmacokinetics of Tiagabine are unchanged in this population, no specific dose modification is necessary. It is important for elderly patients to be monitored closely for side effects, as they may be more sensitive to the medication.
What are the most common side effects of Tiagabine?
Side effects are unwanted reactions to a medication. Common side effects of Tiagabine include dizziness, tiredness, and difficulty concentrating. These effects vary from person to person. If you notice new symptoms after starting Tiagabine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the symptoms are related to Tiagabine.
Who should avoid taking Tiagabine?
Don't take Tiagabine if you're allergic to it or its ingredients. It's not recommended for people without epilepsy, as it can cause seizures. Caution is needed for those with liver problems, as Tiagabine is processed by the liver. Always consult your doctor about these concerns and inform them of your medical history before starting Tiagabine.
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