Tetrabenazine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Vesicular Monoamine Transporter 2 Inhibitor
Controlled Drug Substance
NO
Tetrabenazine
Summary
Tetrabenazine is primarily used to manage movement disorders, particularly chorea - involuntary jerky movements, often seen in conditions like Huntington's disease.
Tetrabenazine works by affecting certain chemicals in the brain, particularly dopamine, which is involved in controlling abnormal movements.
Tetrabenazine is usually started at a dose of 12.5 mg once daily, taken orally. The dose may be gradually increased to a maximum of 50 to 100 mg per day based on the patient's response and tolerance.
Common side effects of Tetrabenazine can include drowsiness, depression, dizziness, nausea, fatigue, insomnia, and in rare cases, serious mood changes. It may also affect the heart rhythm.
Tetrabenazine should be avoided in people with severe depression, suicidal thoughts, or certain liver conditions. It's also unsuitable if you're taking certain medications like MAO inhibitors. Always discuss risks with your doctor.
Indications and Purpose
How does Tetrabenazine work?
Tetrabenazine works by inhibiting a protein called vesicular monoamine transporter 2 (VMAT2), which is involved in the storage and release of certain chemicals in the brain. By blocking VMAT2, Tetrabenazine reduces the levels of these chemicals, helping to control involuntary movements. Think of it like turning down the volume on a radio to reduce noise. This action helps improve symptoms in conditions like Huntington's disease. It's important to take Tetrabenazine as prescribed to manage your condition effectively.
Is Tetrabenazine effective?
Yes, Tetrabenazine is effective for treating movement disorders like Huntington's disease, which causes involuntary movements. It works by reducing the amount of certain chemicals in the brain that are involved in movement control. Clinical studies show that Tetrabenazine can significantly improve symptoms in people with these conditions. However, the effectiveness can vary from person to person. Regular follow-ups with your doctor are important to monitor your progress and adjust your treatment as needed. Always take Tetrabenazine as prescribed for the best results.
What is Tetrabenazine?
Tetrabenazine is a medication used to treat movement disorders like Huntington's disease, which causes involuntary movements. It belongs to a class of drugs called vesicular monoamine transporter 2 (VMAT2) inhibitors. Tetrabenazine works by reducing the amount of certain chemicals in the brain that are involved in movement control. This helps improve symptoms like involuntary movements. It's important to follow your doctor's instructions when taking Tetrabenazine to manage your condition effectively. Always discuss any concerns or questions with your healthcare provider.
Directions for Use
For how long do I take Tetrabenazine?
Tetrabenazine is usually a long-term medication for managing movement disorders like Huntington's disease. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. The duration of use depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Tetrabenazine treatment. They can help ensure your treatment plan remains safe and effective for your specific health needs.
How do I dispose of Tetrabenazine?
To dispose of Tetrabenazine, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent accidental ingestion.
How do I take Tetrabenazine?
Take Tetrabenazine exactly as your doctor prescribes. Usually, it's taken once or twice daily, with or without food. You can crush the tablet if needed. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Don't take two doses at once. Avoid alcohol while on Tetrabenazine, as it can increase side effects. Always follow your doctor's specific instructions regarding diet and fluid intake while taking this medication.
How long does it take for Tetrabenazine to start working?
Tetrabenazine may start to work within a few days, but it can take several weeks to achieve its full therapeutic effect. The time it takes to work can vary depending on individual factors like your condition and response to the medication. Regular follow-ups with your doctor are important to monitor your progress and adjust your treatment as needed. If you have concerns about how long Tetrabenazine is taking to work, discuss them with your doctor. They can provide guidance and support.
How should I store Tetrabenazine?
Store Tetrabenazine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Don't store it in humid places like bathrooms, as moisture can affect its effectiveness. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Tetrabenazine out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Tetrabenazine?
The usual starting dose of Tetrabenazine for adults is 12.5 mg once daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 50 mg per day, divided into two or three doses. For elderly patients or those with liver problems, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions for your health needs. It's important to take Tetrabenazine exactly as prescribed to manage your condition effectively.
Warnings and Precautions
Can I take Tetrabenazine with other prescription drugs?
Tetrabenazine can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Major interactions include antidepressants, which can increase the risk of depression or suicidal thoughts. Moderate interactions include medications that affect liver enzymes, which can alter Tetrabenazine levels in your body. Always inform your doctor about all medications you take to prevent interactions. They can adjust your treatment plan to ensure safety and effectiveness. Regular check-ups help monitor for any potential drug interactions.
Can Tetrabenazine be taken safely while breastfeeding?
The safety of Tetrabenazine while breastfeeding is not well-established. We don't have much information about whether it passes into breast milk or its effects on a breastfed infant. If you're breastfeeding or planning to breastfeed, discuss the risks and benefits of Tetrabenazine with your doctor. They can help determine the safest treatment plan for you and your baby. It's important to carefully weigh the potential risks and benefits before using Tetrabenazine while breastfeeding.
Can Tetrabenazine be taken safely while pregnant?
The safety of Tetrabenazine during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. Animal studies suggest potential risks, but we lack sufficient data from human observations. If you're pregnant or planning to become pregnant, discuss the risks and benefits of Tetrabenazine with your doctor. They can help determine the safest treatment plan for you and your baby. It's important to carefully weigh the potential risks and benefits before using Tetrabenazine during pregnancy.
Does Tetrabenazine have adverse effects?
Yes, Tetrabenazine can have adverse effects, which are unwanted reactions to the medication. Common adverse effects include drowsiness, fatigue, and nausea. These effects vary in frequency and severity. Serious side effects can include depression and suicidal thoughts, which require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if the symptoms are related to Tetrabenazine and recommend appropriate actions to manage them. Always report any adverse effects to your healthcare provider.
Does Tetrabenazine have any safety warnings?
Yes, Tetrabenazine has important safety warnings. It can increase the risk of depression and suicidal thoughts, especially in people with a history of depression. If you experience mood changes, contact your doctor immediately. Tetrabenazine can also cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Not following these warnings can lead to serious consequences, including worsening mental health or accidents. Always discuss any concerns with your doctor to ensure safe use of Tetrabenazine.
Is it safe to drink alcohol while taking Tetrabenazine?
It's best to avoid alcohol while taking Tetrabenazine. Alcohol can increase the risk of side effects like drowsiness and dizziness. It may also worsen depression, which is a potential side effect of Tetrabenazine. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like increased drowsiness or mood changes. Talk with your doctor about alcohol use while taking Tetrabenazine to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Tetrabenazine?
Yes, you can exercise while taking Tetrabenazine, but be cautious. This medication can cause drowsiness or dizziness, which might affect your exercise capacity. If you feel dizzy or lightheaded during physical activity, slow down or stop and rest. Drink plenty of water to stay hydrated. Avoid strenuous activities or high-impact sports until you know how Tetrabenazine affects you. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns.
Is it safe to stop Tetrabenazine?
No, it's not safe to stop Tetrabenazine suddenly without consulting your doctor. Stopping abruptly can worsen your condition or cause withdrawal symptoms like anxiety or irritability. Tetrabenazine is usually used for long-term management of conditions like movement disorders. If you need to stop taking it, your doctor will guide you on how to gradually reduce the dose to minimize risks. Always talk with your doctor before making any changes to your medication regimen to ensure your safety.
Is Tetrabenazine addictive?
No, Tetrabenazine is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Tetrabenazine works by affecting certain chemicals in the brain, but it doesn't alter brain chemistry in a way that leads to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance on managing your treatment safely.
Is Tetrabenazine safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Tetrabenazine, such as drowsiness and dizziness. These effects can increase the risk of falls or accidents. It's important for elderly patients to be closely monitored by their doctor while taking Tetrabenazine. Dose adjustments may be necessary to minimize risks. If you're an older adult taking Tetrabenazine, discuss any concerns with your doctor. They can help ensure your treatment is safe and effective.
What are the most common side effects of Tetrabenazine?
Common side effects of Tetrabenazine include drowsiness, fatigue, and nausea. These are unwanted reactions that can occur when taking the medication. The frequency of these side effects can vary, and not everyone will experience them. If you notice new symptoms after starting Tetrabenazine, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. They can help determine if the side effects are related to Tetrabenazine and provide guidance on managing them.
Who should avoid taking Tetrabenazine?
Tetrabenazine should not be used if you have untreated or inadequately treated depression, as it can worsen this condition. It's also contraindicated in people with suicidal thoughts or a history of suicide attempts. If you have liver problems, Tetrabenazine may not be suitable for you. Always inform your doctor about your medical history before starting Tetrabenazine. They can assess the risks and benefits and determine if this medication is appropriate for you. Following these guidelines helps ensure safe and effective use of Tetrabenazine.
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