Teriflunomide
Relapsing-Remitting Multiple Sclerosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Pyrimidine Synthesis Inhibitor
Controlled Drug Substance
No
teriflunomide
Summary
Teriflunomide is used to treat relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. It helps reduce the frequency of relapses and slows the progression of physical disability.
Teriflunomide works by inhibiting certain immune cells, which reduces inflammation and slows the progression of multiple sclerosis. It blocks the production of pyrimidine, which is a building block for DNA, limiting the growth of rapidly dividing cells like immune cells.
The usual starting dose of Teriflunomide for adults is 14 mg once daily. It can be taken with or without food. Swallow the tablet whole; do not crush it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose.
Common side effects of Teriflunomide include hair thinning, diarrhea, and nausea. These occur in a small percentage of people taking the medication. If you experience new symptoms after starting Teriflunomide, they might be temporary or unrelated to the medication.
Teriflunomide can cause liver damage, so regular liver function tests are necessary. It is not recommended during pregnancy due to potential harm to the unborn baby. Always consult your doctor before starting Teriflunomide to ensure it's safe for you.
Indications and Purpose
How does Teriflunomide work?
Teriflunomide works by inhibiting the function of certain immune cells, which reduces inflammation and slows the progression of multiple sclerosis. It blocks the production of pyrimidine, which is a building block for DNA, limiting the growth of rapidly dividing cells like immune cells. Think of it like slowing down a fast-moving train to prevent it from causing damage. This helps reduce the frequency of relapses and slows the progression of physical disability in multiple sclerosis.
Is Teriflunomide effective?
Teriflunomide is effective in treating relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. It helps reduce the frequency of relapses and slows the progression of physical disability. Clinical studies support its effectiveness in managing multiple sclerosis symptoms. Regular monitoring by your healthcare provider ensures the medication is working as intended and allows for adjustments if needed.
What is Teriflunomide?
Teriflunomide is a medication used to treat relapsing forms of multiple sclerosis, which is a condition where the immune system attacks the protective covering of nerves. It belongs to a class of drugs called immunomodulators, which help reduce inflammation and slow disease progression. Teriflunomide works by inhibiting the function of certain immune cells, reducing their ability to attack the nervous system. It is used as a long-term treatment to manage symptoms and prevent relapses.
Directions for Use
For how long do I take Teriflunomide?
Teriflunomide is usually a long-term medication for managing multiple sclerosis, which is a chronic condition. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Teriflunomide treatment.
How do I dispose of Teriflunomide?
Dispose of Teriflunomide by taking it to a drug take-back program or collection site at a pharmacy or hospital. If these options are unavailable, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent accidental ingestion or environmental harm.
How do I take Teriflunomide?
Take Teriflunomide once daily, with or without food. Swallow the tablet whole; do not crush it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Avoid alcohol while on this medication, as it can increase the risk of liver problems. Always follow your doctor's specific instructions regarding diet and fluid intake while taking Teriflunomide.
How long does it take for Teriflunomide to start working?
Teriflunomide starts working in your body shortly after you take it, but it may take several weeks to notice its full effects. The time it takes to see improvements can vary based on individual factors like your overall health and the severity of your condition. Regular monitoring by your healthcare provider helps track its effectiveness. Always take Teriflunomide as prescribed for the best results and discuss any concerns with your doctor.
How should I store Teriflunomide?
Store Teriflunomide at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Do not store it in humid places like bathrooms, as moisture can affect its effectiveness. Always keep Teriflunomide out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Teriflunomide?
The usual starting dose of Teriflunomide for adults is 14 mg once daily. It can be taken with or without food. Dose adjustments are not typically needed, but always follow your doctor's instructions. There is no maximum recommended dose beyond 14 mg daily. Special populations, such as children or the elderly, should use this medication only under strict medical supervision. Always consult your healthcare provider for personalized dosing instructions.
Warnings and Precautions
Can I take Teriflunomide with other prescription drugs?
Teriflunomide can interact with other medications, increasing the risk of adverse effects. For example, it can interact with warfarin, which is a blood thinner, increasing bleeding risk. It may also interact with other immunosuppressants, increasing infection risk. Always inform your doctor about all medications you are taking to prevent interactions. Your healthcare provider can help manage these interactions and adjust your treatment plan as needed.
Can Teriflunomide be taken safely while breastfeeding?
Teriflunomide is not recommended while breastfeeding. It is unknown if it passes into human breast milk, but it could potentially harm a nursing infant. If you are breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. Your doctor can help you choose a treatment that allows you to nurse your baby safely. Always inform your healthcare provider about your breastfeeding plans while on Teriflunomide.
Can Teriflunomide be taken safely while pregnant?
Teriflunomide is not recommended during pregnancy due to potential harm to the unborn baby. It can cause birth defects and other serious problems. If you are pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby. Always inform your healthcare provider if you become pregnant while taking Teriflunomide.
Does Teriflunomide have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Teriflunomide include hair thinning, diarrhea, and nausea. These effects vary in frequency and severity. Serious side effects can include liver damage and high blood pressure. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Teriflunomide and suggest appropriate actions to manage them.
Does Teriflunomide have any safety warnings?
Yes, Teriflunomide has important safety warnings. It can cause liver damage, so regular liver function tests are necessary. It may also lower blood cell counts, increasing infection risk. Not adhering to these warnings can lead to serious health issues. If you experience symptoms like jaundice, which is yellowing of the skin or eyes, or unusual fatigue, contact your doctor immediately. Always follow your healthcare provider's advice to minimize risks.
Is it safe to drink alcohol while taking Teriflunomide?
It's best to avoid alcohol while taking Teriflunomide. Alcohol can increase the risk of liver damage, which is a serious side effect of this medication. If you choose to drink occasionally, limit your alcohol intake and monitor for symptoms like nausea or jaundice, which is yellowing of the skin or eyes. These could indicate liver problems. Always talk with your doctor about alcohol use while taking Teriflunomide for personalized advice.
Is it safe to exercise while taking Teriflunomide?
Yes, you can exercise while taking Teriflunomide. However, be aware that this medication can cause fatigue, which might affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel unusually tired. Stay hydrated and take breaks as needed. Most people can maintain their regular exercise routine while on Teriflunomide, but consult your doctor if you have concerns about your specific situation.
Is it safe to stop Teriflunomide?
Stopping Teriflunomide suddenly can lead to a return of multiple sclerosis symptoms. It's used long-term for managing this chronic condition. If you need to stop, your doctor may suggest a gradual reduction or an alternative treatment to prevent symptom flare-ups. Always consult your healthcare provider before making any changes to your medication regimen. They can guide you on how to safely adjust your treatment plan.
Is Teriflunomide addictive?
Teriflunomide is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by affecting the immune system to reduce inflammation in multiple sclerosis. It does not affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Teriflunomide does not carry this risk while managing your health condition.
Is Teriflunomide safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Teriflunomide, such as liver damage and high blood pressure. Regular monitoring by a healthcare provider is important to ensure safety. The medication can be used in the elderly, but with caution. Your doctor will assess the risks and benefits based on your overall health and may adjust the treatment plan accordingly. Always follow your doctor's advice when taking Teriflunomide.
What are the most common side effects of Teriflunomide?
Side effects are unwanted reactions to a medication. Common side effects of Teriflunomide include hair thinning, diarrhea, and nausea. These occur in a small percentage of people taking the medication. If you experience new symptoms after starting Teriflunomide, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Teriflunomide and suggest ways to manage them.
Who should avoid taking Teriflunomide?
Do not use Teriflunomide if you have severe liver problems or are pregnant, as it can harm the unborn baby. These are absolute contraindications. Relative contraindications include conditions like active infections, where caution is needed. Always consult your doctor before starting Teriflunomide to ensure it's safe for you. They can assess your health status and determine if the benefits outweigh the risks.
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