Tazemetostat
Sarcoma
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Methyltransferase Inhibitor
Controlled Drug Substance
No
tazemetostat
Summary
Tazemetostat is used to treat certain types of cancer, such as epithelioid sarcoma, which is a rare soft tissue cancer, and follicular lymphoma, which is a type of blood cancer. It helps manage these conditions by slowing down or stopping the growth of cancer cells.
Tazemetostat works by inhibiting the EZH2 protein, which is a protein that helps cancer cells grow. By blocking this protein, Tazemetostat can slow or stop the growth of cancer cells, leading to tumor shrinkage and improved health outcomes.
The usual starting dose of Tazemetostat for adults is 800 mg taken twice daily. It is taken orally, which means by mouth, and can be taken with or without food. It's important to follow your doctor's instructions and not adjust the dose on your own.
Common side effects of Tazemetostat include fatigue, which is a feeling of tiredness, nausea, which is a feeling of sickness in the stomach, and decreased appetite, which means less hunger. These effects are usually mild to moderate.
Tazemetostat should not be used if you are allergic to it or its ingredients. It's also contraindicated in patients with severe liver impairment, which means the liver is not working well. Regular monitoring by your doctor is important to ensure safety.
Indications and Purpose
How does Tazemetostat work?
Tazemetostat works by inhibiting the EZH2 protein, which helps cancer cells grow. Think of it like turning off a switch that allows cancer cells to multiply. By blocking this protein, Tazemetostat can slow or stop the growth of cancer cells, leading to tumor shrinkage and improved health outcomes.
Is Tazemetostat effective?
Tazemetostat is effective for treating certain types of cancer, such as epithelioid sarcoma and follicular lymphoma. It works by inhibiting a protein that helps cancer cells grow. Clinical studies show Tazemetostat can shrink tumors and improve survival rates in some patients. Your doctor will monitor your progress to ensure the medication is working for you.
What is Tazemetostat?
Tazemetostat is a medication used to treat certain types of cancer, such as epithelioid sarcoma and follicular lymphoma. It belongs to a class of drugs called EZH2 inhibitors, which work by blocking a protein that helps cancer cells grow. This medication can be used alone or with other therapies to manage cancer.
Directions for Use
For how long do I take Tazemetostat?
Tazemetostat is usually taken long-term for chronic conditions like certain cancers. The duration of use depends on your response to treatment and any side effects you experience. Your doctor will guide you on how long to continue taking Tazemetostat. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Tazemetostat?
Dispose of Tazemetostat by taking it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Tazemetostat?
Take Tazemetostat as prescribed by your doctor. It's usually taken twice daily, once in the morning and once in the evening, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for Tazemetostat to start working?
Tazemetostat starts working in your body shortly after you take it, but the full therapeutic effect may take weeks to months. The time it takes to see benefits can vary based on your condition and overall health. Regular check-ups with your doctor are important to monitor your progress and adjust treatment as needed.
How should I store Tazemetostat?
Store Tazemetostat at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms. Always keep Tazemetostat out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of expired medication properly.
What is the usual dose of Tazemetostat?
The usual starting dose of Tazemetostat for adults is 800 mg taken twice daily. Your doctor will provide specific dosing instructions based on your health needs. It's important to follow your doctor's guidance and not adjust the dose on your own. If you have any concerns about your dosage, discuss them with your healthcare provider.
Warnings and Precautions
Can I take Tazemetostat with other prescription drugs?
Tazemetostat can interact with certain medications, such as strong CYP3A inhibitors, which may increase the risk of side effects. It's important to inform your doctor about all the medications you're taking to avoid interactions. Your doctor can adjust your treatment plan to ensure it's safe and effective.
Can Tazemetostat be taken safely while breastfeeding?
Tazemetostat is not recommended while breastfeeding. There's limited information on whether it passes into breast milk, but it may pose risks to a nursing infant. If you're taking Tazemetostat and want to breastfeed, discuss safer medication options with your doctor to ensure your baby's safety.
Can Tazemetostat be taken safely while pregnant?
Tazemetostat is not recommended during pregnancy. There's limited information on its safety for pregnant women, and it may harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a plan that protects both you and your baby.
Does Tazemetostat have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Tazemetostat include fatigue, nausea, and decreased appetite. These effects vary in frequency and severity. Serious side effects, like secondary cancers, require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Tazemetostat.
Does Tazemetostat have any safety warnings?
Yes, Tazemetostat has safety warnings. It may increase the risk of secondary cancers, such as T-cell lymphoblastic lymphoma. Regular monitoring by your doctor is important. If you experience unusual symptoms like persistent fever or unexplained weight loss, contact your healthcare provider immediately. Adhering to safety warnings helps prevent serious health issues.
Is it safe to drink alcohol while taking Tazemetostat?
It's best to avoid alcohol while taking Tazemetostat. Alcohol can increase the risk of liver damage and worsen side effects like nausea. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or stomach pain. Talk with your doctor about alcohol use while on Tazemetostat.
Is it safe to exercise while taking Tazemetostat?
You can exercise while taking Tazemetostat, but be mindful of side effects like fatigue or dizziness. These might limit your exercise capacity. To exercise safely, listen to your body and rest if you feel tired. Stay hydrated and avoid strenuous activities if you experience any symptoms. Consult your doctor if you have concerns.
Is it safe to stop Tazemetostat?
Stopping Tazemetostat suddenly can affect your treatment. It's important to talk with your doctor before stopping the medication. Your doctor might suggest a gradual reduction or an alternative treatment to ensure your condition remains under control. Always follow your doctor's guidance to protect your health.
Is Tazemetostat addictive?
Tazemetostat is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Tazemetostat safe for the elderly?
Elderly patients may be more vulnerable to side effects of Tazemetostat, such as fatigue and decreased appetite. It's important for older adults to be closely monitored by their doctor while taking this medication. Regular check-ups help ensure the treatment is safe and effective for elderly patients.
What are the most common side effects of Tazemetostat?
Side effects are unwanted reactions to a medication. Common side effects of Tazemetostat include fatigue, nausea, and decreased appetite. These effects vary from person to person. If you notice new symptoms after starting Tazemetostat, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Tazemetostat?
Tazemetostat should not be used if you are allergic to it or its ingredients. It's also contraindicated in patients with severe liver impairment. Caution is needed if you have a history of secondary cancers. Always consult your doctor about your medical history before starting Tazemetostat to ensure it's safe for you.
