Tadalafil
Pulmonary Hypertension, Vasculogenic Impotence
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Phosphodiesterase 5 Inhibitor
Controlled Drug Substance
NO
Tadalafil
Summary
Tadalafil is used to treat erectile dysfunction, which is difficulty getting or keeping an erection. It also treats benign prostatic hyperplasia, which is an enlarged prostate causing urinary issues, and pulmonary arterial hypertension, which is high blood pressure in the lungs.
Tadalafil works by relaxing blood vessels, which increases blood flow to certain areas. For erectile dysfunction, it increases blood flow to the penis. For benign prostatic hyperplasia, it relaxes muscles in the prostate and bladder. In pulmonary arterial hypertension, it relaxes blood vessels in the lungs.
Tadalafil is usually taken as a tablet by mouth. For erectile dysfunction, it's often taken as needed before sexual activity, with a starting dose of 10 mg. For daily use, the dose is typically 2.5 mg to 5 mg. Always follow your doctor's specific dosing instructions.
Common side effects of Tadalafil include headaches, which are pain in the head, flushing, which is redness of the skin, indigestion, which is stomach discomfort, and back pain. These effects are usually mild and temporary.
Tadalafil should not be taken with nitrates, which are medications for chest pain, as this can cause a dangerous drop in blood pressure. Avoid it if you have severe heart or liver problems. Always consult your doctor about your health conditions before taking Tadalafil.
Indications and Purpose
How does Tadalafil work?
Tadalafil works by relaxing blood vessels, which increases blood flow to certain areas of the body. For erectile dysfunction, it helps increase blood flow to the penis, aiding in getting and maintaining an erection. For benign prostatic hyperplasia, it relaxes muscles in the prostate and bladder, improving urine flow. In pulmonary arterial hypertension, it relaxes blood vessels in the lungs, reducing blood pressure and improving exercise ability. This makes Tadalafil effective for these conditions.
Is Tadalafil effective?
Yes, Tadalafil is effective for treating erectile dysfunction, which is difficulty getting or keeping an erection. It works by increasing blood flow to the penis. Clinical studies show Tadalafil improves erectile function in many men. It's also used to treat benign prostatic hyperplasia, which is an enlarged prostate, and pulmonary arterial hypertension, which is high blood pressure in the lungs. Always follow your doctor's instructions for the best results.
What is Tadalafil?
Tadalafil is a medication used to treat erectile dysfunction, which is difficulty getting or keeping an erection. It belongs to a class of drugs called phosphodiesterase type 5 inhibitors, which work by increasing blood flow to the penis. Tadalafil is also used to treat benign prostatic hyperplasia, which is an enlarged prostate, and pulmonary arterial hypertension, which is high blood pressure in the lungs. It helps improve symptoms and quality of life for people with these conditions.
Directions for Use
For how long do I take Tadalafil?
Tadalafil is often used as needed for erectile dysfunction, so you take it before sexual activity. For conditions like benign prostatic hyperplasia or pulmonary arterial hypertension, it may be prescribed for long-term use. The duration depends on your condition and how you respond to treatment. Always follow your doctor's instructions and talk with them before making any changes to your medication. They can help determine the best treatment plan for your needs.
How do I dispose of Tadalafil?
Dispose of Tadalafil by taking it to a drug take-back program or collection site at a pharmacy or hospital. This ensures it doesn't harm people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. Always keep medications out of reach of children and pets.
How do I take Tadalafil?
Take Tadalafil as your doctor prescribes. It's usually taken once a day or as needed before sexual activity. You can take it with or without food. Swallow the tablet whole; don't crush or split it. If you miss a dose and take it daily, take it as soon as you remember, but skip it if it's almost time for your next dose. Don't double up doses. Avoid excessive alcohol, as it can increase side effects. Always follow your doctor's specific instructions for the best results.
How long does it take for Tadalafil to start working?
Tadalafil usually starts working within 30 minutes to 2 hours after taking it. The time it takes to work can vary based on individual factors like age, health, and other medications. For erectile dysfunction, you may notice improved erections within this time frame. For other conditions like benign prostatic hyperplasia, it may take a few days to weeks to see full benefits. Always take Tadalafil as prescribed for the best results.
How should I store Tadalafil?
Store Tadalafil at room temperature, away from moisture and light. Keep it in its original packaging until you're ready to take it. Don't store it in the bathroom, where humidity can affect it. Make sure it's out of reach of children and pets. Check the expiration date regularly and dispose of any unused or expired medication properly. If you have questions about storage, ask your pharmacist or doctor for guidance.
What is the usual dose of Tadalafil?
The usual starting dose of Tadalafil for erectile dysfunction is 10 mg taken before sexual activity. Depending on how you respond, your doctor may adjust the dose to 20 mg or lower it to 5 mg. For daily use, the typical dose is 2.5 mg to 5 mg once a day. The maximum recommended dose is 20 mg. Always follow your doctor's specific dosing instructions, especially if you have other health conditions or are taking other medications.
Warnings and Precautions
Can I take Tadalafil with other prescription drugs?
Tadalafil can interact with nitrates, which are medications for chest pain, causing a dangerous drop in blood pressure. It can also interact with alpha-blockers, which are used for high blood pressure or prostate problems, leading to low blood pressure. Some antifungal and antibiotic medications can increase Tadalafil levels in your blood, raising the risk of side effects. Always inform your doctor about all medications you take to avoid harmful interactions.
Can Tadalafil be taken safely while breastfeeding?
Tadalafil is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. Without clear data, we can't rule out potential risks to a breastfed baby. If you're taking Tadalafil and want to breastfeed, talk with your doctor about safer medication options. They can help you find a treatment that allows you to nurse your baby safely.
Can Tadalafil be taken safely while pregnant?
Tadalafil is not recommended during pregnancy. There's limited evidence on its safety for pregnant women. Animal studies suggest potential risks, but we don't have enough information from human studies. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition. Your doctor can help create a plan that protects both you and your baby.
Does Tadalafil have adverse effects?
Adverse effects are unwanted reactions to a medication. Tadalafil can cause headaches, indigestion, back pain, and muscle aches. These are common and usually mild. Serious adverse effects include sudden vision or hearing loss and an erection lasting more than 4 hours, which requires immediate medical attention. If you experience any severe or persistent side effects, contact your doctor. They can help determine if Tadalafil is the cause and suggest ways to manage these effects.
Does Tadalafil have any safety warnings?
Yes, Tadalafil has important safety warnings. It can cause a sudden drop in blood pressure, especially if taken with nitrates, which are medications for chest pain. This can lead to dizziness or fainting. Tadalafil can also cause vision or hearing changes. If you experience chest pain, dizziness, or a prolonged erection lasting more than 4 hours, seek medical help immediately. Always follow your doctor's advice and inform them of any other medications you are taking to avoid serious interactions.
Is it safe to drink alcohol while taking Tadalafil?
It's best to limit alcohol while taking Tadalafil. Alcohol can increase the risk of side effects like dizziness or low blood pressure. Drinking too much alcohol can also affect your ability to get an erection. If you choose to drink, do so in moderation and watch for any warning signs like dizziness or fainting. Talk with your doctor about alcohol use while taking Tadalafil to get personalized advice based on your health.
Is it safe to exercise while taking Tadalafil?
Yes, you can exercise while taking Tadalafil, but be cautious. Tadalafil can cause dizziness or a drop in blood pressure, especially if you exercise strenuously. Start with light to moderate activities and see how your body responds. Drink plenty of water to stay hydrated. If you feel dizzy or lightheaded, stop exercising and rest. Talk with your doctor if you have concerns about exercising while on Tadalafil.
Is it safe to stop Tadalafil?
Yes, it's generally safe to stop Tadalafil, but talk to your doctor first. Tadalafil is often used as needed for erectile dysfunction, so stopping won't cause withdrawal symptoms. However, if you're using it for a chronic condition, stopping might affect your symptoms. Always consult your doctor before making changes to your medication to ensure it's safe and won't negatively impact your health.
Is Tadalafil addictive?
Tadalafil is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Tadalafil works by increasing blood flow to certain areas of the body, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Tadalafil doesn't carry this risk.
Is Tadalafil safe for the elderly?
Tadalafil is generally safe for the elderly, but they may be more sensitive to its effects. Older adults are more likely to have health conditions or take medications that could interact with Tadalafil. They may also be more prone to side effects like dizziness or low blood pressure. It's important for elderly patients to follow their doctor's instructions and report any unusual symptoms. Regular check-ups can help ensure safe and effective use of Tadalafil.
What are the most common side effects of Tadalafil?
Side effects are unwanted reactions to a medication. Common side effects of Tadalafil include headaches, flushing, indigestion, and back pain. These occur in more than 10% of users and are usually mild. If you experience these side effects, they might be temporary or unrelated to the medication. Talk with your doctor if they persist or worsen. They can help determine if Tadalafil is the cause and suggest ways to manage these effects.
Who should avoid taking Tadalafil?
Don't take Tadalafil if you're allergic to it or its ingredients. It's contraindicated with nitrates, which are medications for chest pain, as this can cause a dangerous drop in blood pressure. Avoid Tadalafil if you have severe heart or liver problems. Use caution if you have kidney disease or a history of stroke. Always consult your doctor about your health conditions before taking Tadalafil to ensure it's safe for you.
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