Sunitinib
Renal Cell Carcinoma, Gastrointestinal Stromal Tumors ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
sunitinib
Summary
Sunitinib is used to treat certain types of cancer, including kidney cancer and gastrointestinal stromal tumors, which are tumors in the digestive tract. It helps slow the progression of these cancers by blocking proteins that promote cancer cell growth.
Sunitinib works by blocking proteins called tyrosine kinases, which are involved in the growth and spread of cancer cells. This action helps slow down the progression of cancer, making it an effective treatment for certain types of cancer.
The usual starting dose of Sunitinib for adults is 50 mg once daily, taken for four weeks followed by a two-week break. This cycle is repeated. It is taken orally, which means by mouth, and your doctor may adjust the dose based on your response and side effects.
Common side effects of Sunitinib include fatigue, which means feeling very tired, diarrhea, which is frequent loose or watery stools, and skin changes like rash or discoloration. These effects are usually mild to moderate in severity.
Sunitinib can cause serious liver problems, so regular liver function tests are needed. It may also increase the risk of heart problems, including heart failure, which is when the heart doesn't pump blood as well as it should. It's not recommended during pregnancy or breastfeeding.
Indications and Purpose
How does Sunitinib work?
Sunitinib works by blocking proteins called tyrosine kinases, which are involved in the growth and spread of cancer cells. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, Sunitinib helps slow the progression of cancer. This mechanism makes it effective for treating certain types of cancer, including kidney cancer and gastrointestinal stromal tumors.
Is Sunitinib effective?
Yes, Sunitinib is effective for treating certain types of cancer, including kidney cancer and gastrointestinal stromal tumors. It works by blocking proteins that promote cancer cell growth. Clinical studies show Sunitinib improves survival rates and delays disease progression in these cancers. Its effectiveness is supported by evidence from clinical trials and patient outcomes. Always follow your doctor's advice to get the best results from your treatment.
What is Sunitinib?
Sunitinib is a medication used to treat certain types of cancer, including kidney cancer and gastrointestinal stromal tumors. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking proteins that promote cancer cell growth. Sunitinib helps slow the progression of cancer and can be used alone or with other therapies. It is an important treatment option for managing these cancers.
Directions for Use
For how long do I take Sunitinib?
Sunitinib is usually taken long-term for chronic conditions like cancer. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will determine how long you need to take Sunitinib based on your specific health needs. Always talk with your doctor before changing or stopping your Sunitinib treatment.
How do I dispose of Sunitinib?
Dispose of unused Sunitinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Sunitinib?
Take Sunitinib once daily, preferably at the same time each day. You can take it with or without food. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Avoid grapefruit and grapefruit juice while taking Sunitinib, as they can interfere with the medication's effectiveness.
How long does it take for Sunitinib to start working?
Sunitinib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on your specific condition and overall health. Regular check-ups with your doctor are important to monitor your progress and adjust your treatment as needed. Always take Sunitinib exactly as prescribed for the best results.
How should I store Sunitinib?
Store Sunitinib at room temperature, between 68°F to 77°F, in a tightly closed container to protect it from moisture and light. Do not keep your medicine in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store Sunitinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Sunitinib?
The usual starting dose of Sunitinib for adults is 50 mg once daily, taken for four weeks followed by a two-week break. This cycle is repeated. Your doctor may adjust the dose based on your response and side effects. The maximum recommended dose is 50 mg daily. Dose adjustments may be needed for special populations, such as those with liver or kidney problems. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can I take Sunitinib with other prescription drugs?
Sunitinib can interact with certain prescription drugs, increasing the risk of adverse effects. For example, it can interact with CYP3A4 inhibitors like ketoconazole, which can increase Sunitinib levels in the body. This may lead to more side effects. Always inform your doctor about all medications you are taking to avoid interactions and ensure your treatment is safe and effective.
Can Sunitinib be taken safely while breastfeeding?
Sunitinib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, it may pose risks to a breastfed infant. We also don't know how this medication might affect your milk production. If you're taking Sunitinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Sunitinib be taken safely while pregnant?
Sunitinib is not recommended during pregnancy. It can harm an unborn baby, as animal studies show it may cause birth defects. We don't have much information about Sunitinib use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby.
Does Sunitinib have adverse effects?
Yes, Sunitinib can cause adverse effects, which are unwanted reactions to the medication. Common adverse effects include fatigue, diarrhea, and skin changes. These occur in more than 10% of people taking Sunitinib. Serious side effects include liver problems, heart issues, and high blood pressure. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Sunitinib and suggest appropriate actions.
Does Sunitinib have any safety warnings?
Yes, Sunitinib has important safety warnings. It can cause serious liver problems, so regular liver function tests are needed. It may also increase the risk of heart problems, including heart failure. High blood pressure is another concern, so monitor your blood pressure regularly. Not following these warnings can lead to severe health issues. Always discuss any concerns with your doctor and follow their advice closely.
Is it safe to drink alcohol while taking Sunitinib?
It's best to avoid alcohol while taking Sunitinib. Alcohol can increase the risk of liver damage, which is a concern with Sunitinib. Drinking alcohol may also worsen side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Sunitinib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Sunitinib?
You can exercise while taking Sunitinib, but be cautious. This medication can cause fatigue and dizziness, which might affect your ability to exercise. Listen to your body and avoid strenuous activities if you feel tired or dizzy. To exercise safely, drink plenty of water before, during, and after physical activity. If you notice any unusual symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Sunitinib?
Stopping Sunitinib suddenly can cause your cancer to progress. It's usually used long-term for chronic conditions like cancer. If you stop taking it without medical advice, your condition may worsen. Always talk with your doctor before stopping Sunitinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Sunitinib addictive?
No, Sunitinib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Sunitinib works by targeting specific proteins in cancer cells, which does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Sunitinib does not carry this risk.
Is Sunitinib safe for the elderly?
Elderly patients are more vulnerable to the side effects of Sunitinib, such as fatigue and high blood pressure. They may also have other health conditions that increase the risk of adverse effects. Sunitinib can be used in the elderly, but with caution. Regular monitoring and dose adjustments may be needed to ensure safety. Always consult your doctor about the risks and benefits of Sunitinib for elderly patients.
What are the most common side effects of Sunitinib?
Common side effects of Sunitinib include fatigue, diarrhea, and skin changes like rash or discoloration. These occur in more than 10% of people taking the medication. Side effects are unwanted reactions that can happen when taking a medication. If you notice new symptoms after starting Sunitinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Sunitinib?
Do not take Sunitinib if you're allergic to it or its ingredients. It's contraindicated in people with severe liver problems, as it can worsen liver function. Caution is needed for those with heart issues, as Sunitinib can increase the risk of heart problems. Always consult your doctor about these concerns to ensure Sunitinib is safe for you.
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