Stavudine
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
NO
Stavudine
Summary
Stavudine is used to treat human immunodeficiency virus (HIV) infection. It helps prevent the progression to acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.
Stavudine works by inhibiting an enzyme that HIV uses to replicate itself. By blocking this enzyme, it reduces the amount of HIV in the blood, helping to prevent the progression of the infection.
The usual dose of Stavudine for adults is typically 30 mg to 40 mg taken twice daily, depending on body weight. For children, the dose is determined based on their weight. It's usually taken orally with or without food.
Common side effects of Stavudine include headache, diarrhea, and rash. Serious side effects include lactic acidosis, pancreatitis, and peripheral neuropathy.
Stavudine has warnings including the risk of lactic acidosis and pancreatitis, which can be life-threatening. It's contraindicated in individuals with a history of pancreatitis or significant liver disease. Pregnant women should use caution, especially if taking didanosine concurrently.
Indications and Purpose
How does Stavudine work?
Stavudine works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of HIV. By blocking this enzyme, stavudine reduces the amount of virus in the blood, helping to improve immune function and slow the progression of HIV-related illnesses.
Is Stavudine effective?
Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) used to treat HIV infection. It works by decreasing the amount of HIV in the blood, which helps improve immune function and reduces the risk of developing AIDS and related illnesses. Clinical studies have shown its effectiveness in combination with other antiretroviral medications.
What is Stavudine?
Stavudine is used to treat HIV infection by reducing the amount of the virus in the blood. It belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). While it does not cure HIV, it helps prevent the progression to AIDS and related illnesses. It is often used in combination with other antiretroviral medications.
Directions for Use
For how long do I take Stavudine?
Stavudine is used as part of a long-term treatment plan for HIV infection. The duration of use is determined by your healthcare provider based on your condition and response to treatment. Do not stop taking it without consulting your doctor.
How do I take Stavudine?
Stavudine can be taken with or without food, but it should be taken with plenty of water. It's important to take it at the same times each day to maintain consistent levels in your body. There are no specific food restrictions, but avoid alcohol while taking this medication.
How should I store Stavudine?
Store stavudine capsules at room temperature, away from excess heat and moisture. The oral solution should be kept in the refrigerator and any unused portion should be disposed of after 30 days. Keep all medication out of reach of children and do not flush it down the toilet.
What is the usual dose of Stavudine?
The usual dose of stavudine for adults is typically 30 mg to 40 mg taken twice daily, depending on body weight. For children, the dose is based on body weight and should be determined by a healthcare provider. Always follow your doctor's specific instructions for dosing.
Warnings and Precautions
Can I take Stavudine with other prescription drugs?
Stavudine should not be taken with didanosine (Videx) due to increased risk of side effects like lactic acidosis and pancreatitis. Inform your doctor of all medications you are taking to avoid harmful interactions. Your doctor may adjust doses or monitor you closely for side effects.
Can Stavudine be taken safely while breastfeeding?
Breastfeeding is not recommended for women taking stavudine or those infected with HIV, as the virus can be transmitted to the baby through breast milk. Consult your doctor for alternative feeding options to ensure the safety of your child.
Can Stavudine be taken safely while pregnant?
Stavudine may pose risks during pregnancy, especially when combined with didanosine. Pregnant women should discuss potential risks and benefits with their doctor. There is no strong evidence from human studies on fetal harm, but caution is advised. Always consult your healthcare provider for personalized advice.
Is it safe to drink alcohol while taking Stavudine?
Drinking alcohol while taking stavudine is not recommended as it may increase the risk of serious side effects like pancreatitis. It's important to avoid alcohol to ensure the safe use of this medication.
Who should avoid taking Stavudine?
Stavudine can cause serious side effects like lactic acidosis and pancreatitis. The risk is higher for women, those who are overweight, and those with liver disease. Avoid alcohol and inform your doctor of any other medications you are taking. Regular monitoring by a healthcare provider is essential.
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