Sotorasib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Sotorasib
Summary
Sotorasib is used to treat non-small cell lung cancer, which is a type of lung cancer, with a specific KRAS mutation, which is a change in the KRAS gene that can cause cancer cells to grow.
Sotorasib works by targeting and inhibiting the KRAS protein, which is involved in cell growth, helping to slow down the growth of cancer cells in non-small cell lung cancer.
The usual starting dose of Sotorasib for adults is 960 mg taken once daily. It is taken orally, which means by mouth, and can be taken with or without food.
Common side effects of Sotorasib include diarrhea, which is frequent loose stools, nausea, which is feeling sick to your stomach, and fatigue, which is feeling very tired.
Sotorasib may cause liver problems, so regular liver function tests are recommended. It is not recommended during pregnancy or breastfeeding due to potential harm to the baby.
Indications and Purpose
How does Sotorasib work?
Sotorasib works by inhibiting the KRAS protein, which is involved in cell growth. Think of it like turning off a switch that allows cancer cells to grow. By blocking this protein, Sotorasib helps slow the growth of cancer cells in non-small cell lung cancer with a specific KRAS mutation.
Is Sotorasib effective?
Sotorasib is effective for treating non-small cell lung cancer with a specific KRAS mutation. Clinical studies show it can shrink tumors and slow disease progression. The effectiveness varies among individuals, but many patients experience significant health benefits. Always discuss your treatment goals and progress with your doctor.
What is Sotorasib?
Sotorasib is a medication used to treat non-small cell lung cancer with a specific KRAS mutation. It works by targeting and inhibiting the KRAS protein, which helps slow cancer cell growth. Sotorasib is used when other treatments have not been effective. It's taken as a daily oral tablet.
Directions for Use
For how long do I take Sotorasib?
Sotorasib is usually a long-term medication for managing non-small cell lung cancer with a specific KRAS mutation. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and overall health.
How do I dispose of Sotorasib?
Dispose of Sotorasib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with undesirable substances like used coffee grounds, seal it in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Sotorasib?
Take Sotorasib as directed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Sotorasib to start working?
Sotorasib begins working shortly after you take it, but noticeable effects may take weeks. The time to see full benefits varies among individuals. Regular check-ups and imaging tests help monitor its effectiveness. Discuss your progress with your doctor to understand how Sotorasib is working for you.
How should I store Sotorasib?
Store Sotorasib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in humid places like bathrooms. Always keep Sotorasib out of children's reach to prevent accidental ingestion. Check the expiration date regularly and dispose of expired medication properly.
What is the usual dose of Sotorasib?
The usual starting dose of Sotorasib for adults is 960 mg once daily. It should be taken at the same time each day, with or without food. Always follow your doctor's specific dosing instructions. If you have any concerns or experience side effects, consult your healthcare provider for guidance.
Warnings and Precautions
Can I take Sotorasib with other prescription drugs?
Sotorasib can interact with certain medications, including strong CYP3A4 inducers, which may reduce its effectiveness. Always inform your doctor about all the medications you're taking to avoid potential interactions. Your doctor can adjust your treatment plan to ensure Sotorasib works effectively and safely.
Can Sotorasib be taken safely while breastfeeding?
Sotorasib is not recommended while breastfeeding. There's limited information on whether it passes into breast milk or its effects on a breastfed infant. If you're taking Sotorasib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Sotorasib be taken safely while pregnant?
Sotorasib is not recommended during pregnancy. There's limited evidence on its safety, and it may harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a plan that protects both you and your baby.
Does Sotorasib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Sotorasib include diarrhea, nausea, and fatigue. These occur in a significant number of patients. Serious side effects can include liver problems and lung issues. If you notice any new or worsening symptoms, contact your doctor immediately for advice.
Does Sotorasib have any safety warnings?
Yes, Sotorasib has safety warnings. It may cause liver problems, so regular liver function tests are recommended. If you experience symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, contact your doctor immediately. Not adhering to these warnings can lead to serious health issues.
Is it safe to drink alcohol while taking Sotorasib?
It's best to avoid alcohol while taking Sotorasib. Alcohol can affect liver function, and Sotorasib may also impact the liver. Drinking alcohol could increase the risk of liver problems. If you choose to drink, limit your intake and discuss it with your doctor to get personalized advice.
Is it safe to exercise while taking Sotorasib?
You can exercise while taking Sotorasib, but be mindful of your body's response. This medication can cause fatigue, which might affect your exercise capacity. Stay hydrated and avoid strenuous activities if you feel unusually tired. Consult your doctor if you have concerns about your specific situation.
Is it safe to stop Sotorasib?
Stopping Sotorasib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Sotorasib. They might suggest a gradual reduction or alternative treatment to keep your condition under control.
Is Sotorasib addictive?
Sotorasib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Sotorasib works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Sotorasib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Sotorasib, such as liver problems and fatigue. It's important for older adults to have regular check-ups to monitor their health while on this medication. Always discuss any concerns or symptoms with your doctor to ensure safe use.
What are the most common side effects of Sotorasib?
Side effects are unwanted reactions to a medication. Common side effects of Sotorasib include diarrhea, nausea, and fatigue. These occur in a significant number of patients. If you notice new symptoms after starting Sotorasib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Sotorasib?
Do not take Sotorasib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Caution is needed for patients with liver problems, as Sotorasib can affect liver function. Always consult your doctor about any concerns or existing health conditions before starting Sotorasib.
