Sonidegib
Skin Neoplasms
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Hedgehog Pathway Inhibitor
Controlled Drug Substance
No
Sonidegib
Summary
Sonidegib is used to treat advanced basal cell carcinoma, which is a type of skin cancer. It's particularly beneficial for patients who cannot undergo surgery or radiation therapy. This medication helps manage the disease by slowing down or stopping the growth of cancer cells.
Sonidegib works by inhibiting the hedgehog signaling pathway, which is a route that cancer cells use to grow. By blocking this pathway, Sonidegib helps slow down or stop the growth of cancer cells, making it effective for treating advanced basal cell carcinoma.
The usual starting dose of Sonidegib for adults is 200 mg taken once daily. It's important to take it on an empty stomach, at least one hour before or two hours after a meal. Always follow your doctor's specific dosing instructions for the best results.
Common side effects of Sonidegib include muscle spasms, hair loss, and fatigue, which means feeling very tired. These effects occur in more than 10% of patients. If you experience any new or worsening symptoms, contact your doctor for advice.
Sonidegib can cause serious birth defects, so it's crucial to avoid pregnancy while taking it. Women of childbearing potential should use effective contraception during treatment and for 20 months after the last dose. It's also contraindicated in patients with severe liver impairment.
Indications and Purpose
How does Sonidegib work?
Sonidegib works by inhibiting the hedgehog signaling pathway, which is involved in the growth of cancer cells. Think of it like blocking a road that cancer cells use to travel and grow. By blocking this pathway, Sonidegib helps slow down or stop the growth of cancer cells, making it effective for treating advanced basal cell carcinoma.
Is Sonidegib effective?
Sonidegib is effective for treating advanced basal cell carcinoma, which is a type of skin cancer, when surgery or radiation isn't an option. It works by inhibiting a pathway that cancer cells use to grow. Clinical studies show Sonidegib can shrink tumors and slow disease progression, improving health outcomes for patients.
What is Sonidegib?
Sonidegib is a medication used to treat advanced basal cell carcinoma, which is a type of skin cancer. It belongs to a class of drugs called hedgehog pathway inhibitors, which work by blocking a pathway that cancer cells use to grow. This helps slow down or stop the growth of cancer cells.
Directions for Use
For how long do I take Sonidegib?
Sonidegib is usually taken long-term for managing advanced basal cell carcinoma, which is a type of skin cancer. The duration of use depends on your response to treatment and any side effects you experience. Always follow your doctor's advice on how long to continue taking Sonidegib.
How do I dispose of Sonidegib?
Dispose of Sonidegib through a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This prevents harm to people and the environment.
How do I take Sonidegib?
Take Sonidegib as prescribed by your doctor, usually once daily. It's best to take it on an empty stomach, at least one hour before or two hours after a meal. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for Sonidegib to start working?
Sonidegib starts working in your body shortly after you take it, but noticeable effects on tumor size may take weeks to months. The time it takes to see full benefits can vary based on individual factors like your overall health and how your body responds to the medication. Regular check-ups with your doctor help monitor progress.
How should I store Sonidegib?
Store Sonidegib at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Avoid storing it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any expired medication properly.
What is the usual dose of Sonidegib?
The usual starting dose of Sonidegib for adults is 200 mg once daily. It's important to follow your doctor's specific dosing instructions. Dose adjustments may be necessary based on your response to the medication and any side effects you experience. Always consult your doctor for personalized dosing guidance.
Warnings and Precautions
Can I take Sonidegib with other prescription drugs?
Sonidegib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Strong CYP3A inhibitors, like ketoconazole, can increase Sonidegib levels, leading to more side effects. Always inform your doctor about all medications you're taking to avoid potential interactions.
Can Sonidegib be taken safely while breastfeeding?
Sonidegib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, due to potential risks to the infant, it's advised to avoid breastfeeding while taking Sonidegib. Discuss alternative treatments with your doctor if you wish to breastfeed.
Can Sonidegib be taken safely while pregnant?
Sonidegib is not safe during pregnancy. It can cause severe birth defects. Women of childbearing potential should use effective contraception during treatment and for 20 months after the last dose. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options.
Does Sonidegib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Sonidegib include muscle spasms, hair loss, and fatigue. These occur in more than 10% of patients. Serious side effects can include severe muscle pain or weakness. If you experience any new or worsening symptoms, contact your doctor immediately for advice.
Does Sonidegib have any safety warnings?
Yes, Sonidegib has important safety warnings. It can cause serious birth defects, so it's crucial to avoid pregnancy while taking it. Women of childbearing potential should use effective contraception during treatment and for 20 months after the last dose. Men should use condoms during treatment and for 8 months after the last dose. Not adhering to these warnings can lead to severe consequences.
Is it safe to drink alcohol while taking Sonidegib?
It's best to avoid alcohol while taking Sonidegib. Alcohol can increase the risk of liver damage, which is a concern with this medication. If you choose to drink occasionally, limit your intake and discuss it with your doctor to ensure it's safe for your specific health situation.
Is it safe to exercise while taking Sonidegib?
You can exercise while taking Sonidegib, but be cautious. This medication can cause muscle spasms and fatigue, which might affect your exercise capacity. To exercise safely, stay hydrated and listen to your body. If you feel dizzy or unusually tired, slow down or stop and rest. Consult your doctor if you have concerns.
Is it safe to stop Sonidegib?
Stopping Sonidegib suddenly can affect your treatment outcomes. It's used for long-term management of certain cancers. Stopping without medical advice could lead to disease progression. Always talk with your doctor before stopping Sonidegib. They might suggest a gradual reduction or alternative treatment to maintain control over your condition.
Is Sonidegib addictive?
Sonidegib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by inhibiting a specific pathway in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Sonidegib safe for the elderly?
Elderly patients may be more vulnerable to side effects of Sonidegib, such as muscle spasms and fatigue. They may also have other health conditions that require careful monitoring. It's important for elderly patients to have regular check-ups with their doctor to ensure the medication is safe and effective for them.
What are the most common side effects of Sonidegib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Sonidegib include muscle spasms, hair loss, and fatigue. These occur in more than 10% of patients. If you notice new symptoms after starting Sonidegib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Sonidegib?
Sonidegib should not be used during pregnancy due to the risk of severe birth defects. Women of childbearing potential must use effective contraception. It's also contraindicated in patients with severe liver impairment. Always consult your doctor about any concerns or conditions that might affect your use of Sonidegib.
