Sofosbuvir
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
Controlled Drug Substance
NO
Sofosbuvir
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Click HereSummary
Sofosbuvir is used to treat chronic hepatitis C infections in adults and children. It helps eliminate the virus from the body, reducing the risk of liver damage, cirrhosis, and liver cancer.
Sofosbuvir works by blocking an enzyme called NS5B RNA polymerase, which the hepatitis C virus needs to multiply. This helps clear the infection over time.
For adults, the standard dose of Sofosbuvir is 400 mg once daily. The treatment duration and combination with other medications depend on the specific HCV genotype. Pediatric doses vary based on weight and should be determined by a doctor.
Common side effects of Sofosbuvir include fatigue, headache, nausea, and insomnia. Serious but rare effects include bradycardia (slow heartbeat), especially when taken with amiodarone.
People with severe kidney disease, liver failure without transplant, or those allergic to Sofosbuvir should avoid it. It's also often used with ribavirin, which can cause birth defects, so pregnant women should take precautions. Alcohol should be avoided as it can reduce the medication's effectiveness and worsen side effects.
Indications and Purpose
How does one know if Sofosbuvir is working?
Doctors monitor treatment success by measuring HCV RNA levels in the blood. If the virus is undetectable 12 weeks after treatment ends (SVR12), the patient is considered cured.
How does Sofosbuvir work?
Sofosbuvir blocks the NS5B polymerase enzyme, preventing the hepatitis C virus from multiplying. This helps clear the infection over time.
Is Sofosbuvir effective?
Yes, studies show sofosbuvir has a 90-99% cure rate when combined with other antiviral medications. It is one of the most effective treatments for hepatitis C.
What is Sofosbuvir?
Sofosbuvir is an antiviral medication used to treat hepatitis C virus (HCV) infections. It works by blocking an enzyme called NS5B RNA polymerase, which the virus needs to multiply. This medicine is usually taken with other antiviral drugs to increase effectiveness.
What is Sofosbuvir used for?
Sofosbuvir is used to treat chronic hepatitis C infections in adults and children. It helps eliminate the virus from the body, reducing the risk of liver damage, cirrhosis, and liver cancer.
Directions for Use
For how long do I take Sofosbuvir?
The usual treatment duration is 12 to 24 weeks, depending on the HCV genotype and whether the patient has cirrhosis or previous treatments. A doctor will decide the exact length of therapy.
How do I take Sofosbuvir?
Sofosbuvir should be taken once daily with or without food. Swallow the tablet whole with water, without crushing or chewing it. Avoid grapefruit juice, as it may interfere with the medicine’s effectiveness.
How long does it take for Sofosbuvir to start working?
Sofosbuvir starts working within a few days, but it may take several weeks for the viral load to decrease significantly. Most patients achieve a cure within 12-24 weeks.
How should I store Sofosbuvir?
Store at room temperature (15-30°C) in a dry place, away from moisture and sunlight. Keep it in its original container and out of reach of children.
What is the usual dose of Sofosbuvir?
For adults, the standard dose is 400 mg once daily. The treatment duration and combination with other medications depend on the specific HCV genotype. Pediatric doses vary based on weight, and a doctor should determine the correct dose for children.
Warnings and Precautions
Can I take Sofosbuvir with other prescription drugs?
Some drugs, like rifampin, phenytoin, and amiodarone, can interact with sofosbuvir, reducing its effectiveness or causing severe side effects like slow heart rate. Discuss all medications with your doctor.
Can I take Sofosbuvir with vitamins or supplements?
Most vitamins are safe, but St. John’s Wort should be avoided as it can lower the effectiveness of sofosbuvir. Always consult a doctor before taking supplements.
Can Sofosbuvir be taken safely while breastfeeding?
There is limited data on sofosbuvir in breast milk, but small amounts may pass to the baby. If taking it with ribavirin, breastfeeding should be avoided due to potential risks.
Can Sofosbuvir be taken safely while pregnant?
Sofosbuvir alone is not known to cause birth defects, but it is often used with ribavirin, which is highly unsafe in pregnancy. Women should use effective contraception during and for 6 months after treatment.
Is it safe to drink alcohol while taking Sofosbuvir?
It’s best to avoid alcohol while taking sofosbuvir, as it can increase liver stress and reduce the medication's effectiveness. Alcohol can also worsen side effects such as fatigue and liver damage. Limit alcohol consumption to ensure the best outcome.
Is it safe to exercise while taking Sofosbuvir?
Exercise is generally encouraged while on sofosbuvir, as it helps maintain a healthy liver and improve overall health. However, if you experience muscle pain or fatigue, reduce the intensity of your workouts. Always consult your doctor if you have concerns about exercising during treatment.
Is Sofosbuvir safe for the elderly?
Yes, sofosbuvir is generally safe for elderly patients, but they may have a higher risk of side effects like fatigue and liver-related complications. Dose adjustments are usually not needed.
Who should avoid taking Sofosbuvir?
People with severe kidney disease, liver failure (without transplant), or those allergic to sofosbuvir should avoid it. Pregnant women should take precautions, as it is often used with ribavirin, which can cause birth defects.
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