Sodium Valproate + Valproic Acid

Find more information about this combination medication at the webpages for valproic acid

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Brand Name

Valgress 200mg Tablet CR 10s , Alprotic 333mg/145mg Tablet CR ... show more

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What conditions sodium valproate and valproic acid is used for
Sodium valproate and valproic acid are used to treat epilepsy, which is a condition with recurrent seizures, and bipolar disorder, which involves extreme mood swings. They also help prevent migraine headaches, which are severe headaches often with nausea and light sensitivity. Both drugs stabilize brain activity by increasing gamma-aminobutyric acid (GABA) levels, which calms nerve activity, making them effective for these conditions.
How sodium valproate and valproic acid works in the body
Sodium valproate and valproic acid work by increasing gamma-aminobutyric acid (GABA) levels, which is a neurotransmitter that calms nerve activity in the brain. Sodium valproate, a salt form, is quickly absorbed and converted into valproic acid, the active form. This action stabilizes electrical activity, reducing seizures and mood swings, making them effective for epilepsy and bipolar disorder.
The usual dosages and routes of administration of sodium valproate and valproic acid
The usual adult dose for sodium valproate and valproic acid varies by condition. For epilepsy, the starting dose is around 600 mg per day, adjusted for effectiveness and tolerance. For bipolar disorder, the dose starts lower and increases gradually. Both drugs can be taken with or without food, but with food may reduce stomach upset. Consistent daily timing is important for maintaining blood levels.
The most commonly observed adverse effects of sodium valproate and valproic acid
Common side effects of sodium valproate and valproic acid include nausea, vomiting, dizziness, and drowsiness. Some people may experience weight gain and hair loss. Serious side effects can include liver damage, which affects liver function, and pancreatitis, which is inflammation of the pancreas. Monitoring liver function and blood levels is important to prevent serious complications.
Important safety warnings and contraindications of sodium valproate and valproic acid
Sodium valproate and valproic acid have warnings for liver damage and pancreatitis, requiring regular liver function monitoring. They are contraindicated in people with liver disease or hypersensitivity to these drugs. Not recommended during pregnancy due to birth defect risks. They can interact with other medications, increasing side effects or reducing effectiveness, so informing healthcare providers of all medications is crucial.

Government Approvals

UK(BNF)

WHO Essential Medicine

YES

Known Teratogen

Pharmaceutical Class

Controlled Drug Substance

Summary

What conditions sodium valproate and valproic acid is used for
Sodium valproate and valproic acid are used to treat epilepsy, which is a condition with recurrent seizures, and bipolar disorder, which involves extreme mood swings. They also help prevent migraine headaches, which are severe headaches often with nausea and light sensitivity. Both drugs stabilize brain activity by increasing gamma-aminobutyric acid (GABA) levels, which calms nerve activity, making them effective for these conditions.
How sodium valproate and valproic acid works in the body
Sodium valproate and valproic acid work by increasing gamma-aminobutyric acid (GABA) levels, which is a neurotransmitter that calms nerve activity in the brain. Sodium valproate, a salt form, is quickly absorbed and converted into valproic acid, the active form. This action stabilizes electrical activity, reducing seizures and mood swings, making them effective for epilepsy and bipolar disorder.
The usual dosages and routes of administration of sodium valproate and valproic acid
The usual adult dose for sodium valproate and valproic acid varies by condition. For epilepsy, the starting dose is around 600 mg per day, adjusted for effectiveness and tolerance. For bipolar disorder, the dose starts lower and increases gradually. Both drugs can be taken with or without food, but with food may reduce stomach upset. Consistent daily timing is important for maintaining blood levels.
The most commonly observed adverse effects of sodium valproate and valproic acid
Common side effects of sodium valproate and valproic acid include nausea, vomiting, dizziness, and drowsiness. Some people may experience weight gain and hair loss. Serious side effects can include liver damage, which affects liver function, and pancreatitis, which is inflammation of the pancreas. Monitoring liver function and blood levels is important to prevent serious complications.
Important safety warnings and contraindications of sodium valproate and valproic acid
Sodium valproate and valproic acid have warnings for liver damage and pancreatitis, requiring regular liver function monitoring. They are contraindicated in people with liver disease or hypersensitivity to these drugs. Not recommended during pregnancy due to birth defect risks. They can interact with other medications, increasing side effects or reducing effectiveness, so informing healthcare providers of all medications is crucial.

Indications and Purpose

How does combination of sodium valproate and valproic acid work?

Sodium valproate and valproic acid work by increasing the levels of gamma-aminobutyric acid (GABA), which is a neurotransmitter that helps calm nerve activity in the brain. This action helps to stabilize electrical activity, reducing the occurrence of seizures and mood swings. Sodium valproate, which is a salt form, is quickly absorbed and converted into valproic acid, the active form, in the body. Both substances share this mechanism of action, making them effective in treating conditions like epilepsy and bipolar disorder by calming excessive nerve activity.

How does combination of Sodium valproate and Valproic acid work?

Sodium valproate and valproic acid are both used to treat epilepsy, which is a condition that causes seizures. They work by increasing the amount of a chemical called gamma-aminobutyric acid (GABA) in the brain, which helps calm the nerve activity that leads to seizures. Sodium valproate is the sodium salt form of valproic acid, which means it is more soluble in water and can be absorbed more quickly by the body. This makes it useful for situations where a rapid effect is needed. Valproic acid, on the other hand, is the active form of the medication and is often used in its pure form for long-term treatment. Both medications share the common goal of stabilizing electrical activity in the brain to prevent seizures, but they differ in their chemical form and how quickly they act.

How effective is combination of sodium valproate and valproic acid?

Evidence for the effectiveness of sodium valproate and valproic acid comes from clinical trials and studies showing significant reductions in seizure frequency and mood stabilization. Sodium valproate, which is a salt form, is often used for its rapid absorption and effectiveness in controlling seizures. Valproic acid, which is the active form, is widely studied and proven effective in both epilepsy and bipolar disorder. Both substances share the common mechanism of increasing GABA levels, which helps to calm excessive nerve activity in the brain. This shared action is supported by numerous studies and clinical experiences.

How effective is combination of Sodium valproate and Valproic acid?

Sodium valproate and valproic acid are both used to treat epilepsy, which is a condition that causes seizures, and bipolar disorder, which is a mental health condition that causes extreme mood swings. They work by increasing the amount of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps calm the brain. Sodium valproate is often used in its salt form, which makes it more stable and easier to absorb in the body. Valproic acid, on the other hand, is the active form of the medication and is directly responsible for its therapeutic effects. Both substances share common attributes, such as their ability to prevent seizures and stabilize mood. They are also known for their potential side effects, which can include nausea, dizziness, and weight gain. Despite these side effects, they are considered effective treatments for managing epilepsy and bipolar disorder.

Directions for Use

What is the usual dose of combination of sodium valproate and valproic acid?

The usual adult daily dose of sodium valproate and valproic acid varies based on the condition being treated and individual response. For epilepsy, which is a condition characterized by recurrent seizures, the starting dose is typically around 600 mg per day, which can be adjusted based on effectiveness and tolerance. For bipolar disorder, which involves extreme mood swings, the dose may start lower and be gradually increased. Both substances require careful dosing adjustments to achieve the desired effect while minimizing side effects. It's important to follow the healthcare provider's instructions for dosing.

What is the usual dose of combination of Sodium valproate and Valproic acid?

Sodium valproate and valproic acid are both used to treat epilepsy, which is a neurological disorder that causes seizures. The usual adult daily dose for sodium valproate typically starts at 600 mg per day, which can be increased gradually based on the patient's response and needs. For valproic acid, the starting dose is often around 10 to 15 mg per kilogram of body weight per day, which can also be adjusted. Both medicines work by increasing the amount of a certain chemical in the brain, which helps to calm the brain's electrical activity and prevent seizures. They share common side effects like nausea and dizziness. However, sodium valproate is often preferred for its more stable blood levels, while valproic acid is sometimes chosen for its rapid absorption. Both require regular monitoring to ensure safe and effective use.

How does one take combination of sodium valproate and valproic acid?

Sodium valproate and valproic acid can be taken with or without food, but taking them with food may help reduce stomach upset. It's important to take them at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but it's advisable to avoid alcohol, which can increase the risk of side effects. Both substances share these instructions, ensuring effective and safe use. Following these guidelines helps to minimize side effects and maximize the benefits of the medication.

How does one take combination of Sodium valproate and Valproic acid?

Sodium valproate and Valproic acid are both used to treat epilepsy, which is a condition that causes seizures, and bipolar disorder, which is a mental health condition that causes extreme mood swings. Both medicines can be taken with or without food, but taking them with food may help reduce stomach upset. There are no specific food restrictions for either medicine, but it's important to maintain a balanced diet. Sodium valproate is often used in its salt form, which can be more easily absorbed by the body. Valproic acid is the active form of the medicine. Both medicines work by increasing the amount of a certain chemical in the brain, which helps to calm the brain's electrical activity. It's important to follow your doctor's instructions and not to stop taking these medicines suddenly, as this can cause seizures to return.

For how long is combination of sodium valproate and valproic acid taken?

The duration of use for sodium valproate and valproic acid depends on the condition being treated. For epilepsy, which is a condition characterized by recurrent seizures, they may be used long-term to prevent seizures. In bipolar disorder, which involves extreme mood swings, they may be used for extended periods to maintain mood stability. Both substances are often used as part of a long-term treatment plan, and the duration is determined by the healthcare provider based on individual needs and response to treatment. Regular follow-up is important to assess effectiveness and adjust treatment as needed.

For how long is combination of Sodium valproate and Valproic acid taken?

Sodium valproate and Valproic acid are both used to treat epilepsy, which is a condition that causes seizures, and bipolar disorder, which is a mental health condition that causes extreme mood swings. The typical duration of use for both medicines can vary greatly depending on the individual's condition and response to treatment. Some people may need to take these medications for several years, while others might use them for a shorter period. Sodium valproate is often used in its salt form, which can be easier for the body to absorb. Valproic acid, on the other hand, is the active form of the medication. Both medicines work by increasing the amount of a certain chemical in the brain that helps to calm nerve activity. They share common side effects, such as nausea and dizziness, but the specific side effects can vary between individuals.

How long does it take for combination of sodium valproate and valproic acid to work?

Sodium valproate and valproic acid, which are used to treat seizures and mood disorders, generally start working within a few days to a week. Sodium valproate, which is a salt form of valproic acid, is absorbed quickly in the body, leading to a rapid onset of action. Valproic acid, which is the active form, also acts quickly to stabilize electrical activity in the brain. Both substances work by increasing the levels of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps calm nerve activity. The time it takes to notice improvements can vary based on the condition being treated and individual response.

How long does it take for combination of Sodium valproate and Valproic acid to work?

The time it takes for a combination medicine to start working depends on the individual medicines involved. For example, if the combination includes ibuprofen, which is a pain reliever and anti-inflammatory drug, it typically starts working within 20 to 30 minutes. On the other hand, if the combination includes acetaminophen, which is another pain reliever, it usually begins to work within 30 to 60 minutes. Both medicines are used to relieve pain and reduce fever, which means they share the common attribute of providing pain relief. However, ibuprofen also reduces inflammation, which is swelling and redness, while acetaminophen does not. Therefore, the combination medicine may start working within 20 to 60 minutes, depending on the specific medicines included and their unique attributes.

Warnings and Precautions

Are there harms and risks from taking combination of sodium valproate and valproic acid?

Common side effects of sodium valproate and valproic acid include nausea, vomiting, dizziness, and drowsiness. Some people may experience weight gain and hair loss. Significant adverse effects can include liver damage, which is a serious condition affecting the liver, and pancreatitis, which is inflammation of the pancreas. Both substances can also cause an increase in ammonia levels in the blood, leading to confusion or lethargy. It's important to monitor liver function and blood levels regularly while on these medications to prevent serious complications.

Are there harms and risks from taking combination of Sodium valproate and Valproic acid?

Sodium valproate and Valproic acid are medications used to treat epilepsy, which is a disorder characterized by recurrent seizures. They share many common side effects, including nausea, vomiting, dizziness, and drowsiness, which refer to feeling sleepy or tired. Both can also cause weight gain and tremors, which are involuntary shaking movements. Significant adverse effects for both include liver damage and pancreatitis, which is inflammation of the pancreas. They can also lead to blood disorders, which affect the components of blood. Unique to Sodium valproate is the potential for hair loss, while Valproic acid may cause more gastrointestinal issues, which relate to the stomach and intestines. Despite these differences, both medications require regular monitoring by a healthcare provider to manage these risks effectively.

Can I take combination of sodium valproate and valproic acid with other prescription drugs?

Sodium valproate and valproic acid can interact with several prescription drugs, leading to increased side effects or reduced effectiveness. They can increase the levels of other antiepileptic drugs, such as lamotrigine, which is used to treat seizures and bipolar disorder, leading to toxicity. They can also interact with blood thinners like warfarin, which is used to prevent blood clots, increasing the risk of bleeding. Monitoring involves regular blood tests to check drug levels and liver function, as well as observing for any unusual symptoms or side effects. It's important to inform healthcare providers of all medications being taken to manage these interactions effectively.

Can I take combination of Sodium valproate and Valproic acid with other prescription drugs?

Sodium valproate and Valproic acid are essentially the same medication used to treat epilepsy, which is a disorder characterized by recurrent seizures, and bipolar disorder, which is a mental health condition causing extreme mood swings. Both substances can interact with other medications, leading to increased side effects or reduced effectiveness. Common interactions include those with blood thinners like warfarin, which can increase bleeding risk, and other antiepileptic drugs, which may alter their effectiveness. They can also interact with antidepressants, leading to increased sedation or other side effects. Unique to Sodium valproate, it may have specific interactions with certain antibiotics, which can affect its levels in the blood. Valproic acid, on the other hand, may have unique interactions with certain HIV medications, potentially affecting their effectiveness. Always consult a healthcare provider before combining these medications with others.

Can I take combination of sodium valproate and valproic acid if I am pregnant?

Sodium valproate and valproic acid are generally not recommended during pregnancy due to the risk of birth defects and developmental disorders in the baby. These risks include neural tube defects, which are serious birth defects of the brain and spine, and cognitive impairment, which affects learning and development. Both substances can cross the placenta and affect the developing fetus. Women of childbearing age are advised to use effective contraception while taking these medications and to discuss potential risks with their healthcare provider if they are planning to become pregnant or discover they are pregnant.

Can I take combination of Sodium valproate and Valproic acid if I am pregnant?

Sodium valproate and Valproic acid are both used to treat epilepsy, which is a disorder characterized by recurrent seizures, and bipolar disorder, which is a mental health condition causing extreme mood swings. However, they are not considered safe during pregnancy. Both substances can cause serious harm to an unborn baby, including birth defects and developmental disorders. Sodium valproate is a salt form of Valproic acid, and they share similar risks during pregnancy. They can lead to physical malformations and affect the baby's brain development. Women who are pregnant or planning to become pregnant are usually advised to avoid these medications unless no other treatment is effective. Doctors may prescribe them only if the benefits outweigh the risks, and they will closely monitor the pregnancy. It's crucial for women to discuss all potential risks with their healthcare provider before using these medications.

Can I take combination of sodium valproate and valproic acid while breastfeeding?

Sodium valproate and valproic acid can pass into breast milk, but they are generally considered safe for use during breastfeeding. The levels in breast milk are usually low and not expected to harm the nursing infant. However, it's important to monitor the baby for any signs of side effects, such as unusual drowsiness or poor feeding. Both substances share this characteristic of being present in breast milk, and mothers are advised to discuss any concerns with their healthcare provider to ensure the safety of their baby while breastfeeding.

Can I take combination of Sodium valproate and Valproic acid while breastfeeding?

Sodium valproate and Valproic acid are both used to treat epilepsy, which is a disorder characterized by recurrent seizures. When it comes to breastfeeding, both substances are known to pass into breast milk, but generally in low amounts. This means that the risk to the breastfeeding infant is considered low. However, it is important for mothers to monitor their infants for any signs of side effects, such as drowsiness or poor feeding. Sodium valproate and Valproic acid share similar safety profiles during lactation, as they are essentially the same active ingredient. The main difference is in their formulation; Sodium valproate is the sodium salt form, while Valproic acid is the acid form. Despite this difference, their effects and safety considerations during breastfeeding are largely the same. Mothers should always consult with their healthcare provider to weigh the benefits and risks before using these medications while breastfeeding.

Who should avoid taking combination of sodium valproate and valproic acid?

Key warnings for sodium valproate and valproic acid include the risk of liver damage and pancreatitis, which is inflammation of the pancreas. These conditions require regular monitoring of liver function and blood tests. Both substances are contraindicated in people with liver disease or a known hypersensitivity to these medications. They are also not recommended during pregnancy due to the risk of birth defects. It's important to inform healthcare providers of any medical history or other medications being taken to avoid serious complications. Both substances share these warnings and contraindications, emphasizing the need for careful use and monitoring.

Who should avoid taking combination of Sodium valproate and Valproic acid?

Sodium valproate and Valproic acid, which are used to treat epilepsy and bipolar disorder, have important warnings and contraindications. Both medicines can cause serious liver damage, especially in children under two years old, and should be used with caution in people with liver problems. They can also cause birth defects if taken during pregnancy, so women of childbearing age should use effective contraception. Unique to Sodium valproate is the risk of pancreatitis, which is inflammation of the pancreas, and it may also affect blood clotting. Valproic acid, on the other hand, can cause weight gain and hair loss. Common side effects for both include nausea, drowsiness, and dizziness. It's important to have regular blood tests to monitor liver function and blood cell counts while using these medications. Always consult a healthcare provider before starting or stopping these medications.