Silodosin
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Alpha-Adrenergic Blocker
Controlled Drug Substance
NO
Silodosin
Summary
Silodosin is primarily used to treat symptoms of benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges, causing difficulty in urinating and frequent urination.
Silodosin works by blocking certain receptors in the prostate and bladder muscles. This causes the muscles to relax, improving urine flow and reducing BPH symptoms.
The usual adult dosage of Silodosin for BPH is 8 mg once daily, taken with food. It's important to swallow the capsule whole and not crush or chew it.
Common side effects of Silodosin include dizziness, ejaculation disorders, and headache. Less common but serious side effects can include low blood pressure, fainting, and severe allergic reactions.
Silodosin should be used with caution in people with a history of low blood pressure. It is not recommended for patients with severe liver or kidney impairment, or for those with a history of allergic reactions to alpha-blockers. It should also be avoided by those taking strong CYP3A4 inhibitors.
Indications and Purpose
How does Silodosin work?
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the prostate and bladder. By blocking these receptors, Silodosin relaxes smooth muscle in these tissues, improving urine flow and reducing BPH symptoms.
Is Silodosin effective?
Clinical studies have shown that Silodosin significantly improves symptoms of benign prostatic hyperplasia (BPH), such as urinary flow rate and International Prostate Symptom Score (IPSS). Patients reported symptom relief starting from the first scheduled observation and continuing through 12 weeks of treatment.
What is Silodosin?
Silodosin is used to treat symptoms of an enlarged prostate, known as benign prostatic hyperplasia (BPH), in men. It works by relaxing the muscles in the bladder and prostate, which helps improve urine flow and reduce BPH symptoms.
Directions for Use
For how long do I take Silodosin?
Silodosin is used to manage symptoms of benign prostatic hyperplasia (BPH) and is typically taken long-term. It does not cure BPH but helps control symptoms, so it should be continued as prescribed by a healthcare provider.
How do I dispose of Silodosin?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Silodosin?
Silodosin should be taken once daily with a meal to ensure proper absorption and reduce the risk of side effects. Patients should discuss with their doctor about consuming grapefruit or grapefruit juice while on this medication.
How long does it take for Silodosin to start working?
Silodosin can start improving symptoms of benign prostatic hyperplasia (BPH) from the first scheduled observation, with significant symptom relief observed within the first few days of treatment.
How should I store Silodosin?
Store Silodosin at room temperature, between 20°C to 25°C (68°F to 77°F), away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom.
What is the usual dose of Silodosin?
The usual daily dose for adults is 8 mg taken orally once a day with a meal. Silodosin is not indicated for use in children, so there is no recommended dose for pediatric patients.
Warnings and Precautions
Can I take Silodosin with other prescription drugs?
Silodosin should not be used with strong CYP3A4 inhibitors like ketoconazole, as they can increase Silodosin levels in the blood. Caution is advised when used with other alpha-blockers or PDE5 inhibitors, as they can cause symptomatic hypotension.
Can Silodosin be taken safely while breastfeeding?
Silodosin is not indicated for use in women, including those who are breastfeeding. Therefore, it should not be used by breastfeeding mothers.
Can Silodosin be taken safely while pregnant?
Silodosin is not indicated for use in women, especially during pregnancy. There is no strong evidence from human studies on fetal harm, but it is advised that pregnant women avoid this medication.
Does Silodosin have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. For Silodosin, common adverse effects include dizziness, diarrhea, and nasal congestion. Rare but serious effects might include severe allergic reactions, which need immediate medical attention. If you experience new or worsening symptoms, it's important to talk to your healthcare provider before stopping the medicine.
Does Silodosin have any safety warnings?
Silodosin has safety warnings related to its potential to cause dizziness or fainting, especially when standing up quickly. This happens because it can lower blood pressure. To avoid this, rise slowly from sitting or lying positions. If you experience severe dizziness or fainting, contact your doctor. It's also important to inform your doctor about any liver or kidney issues before starting Silodosin.
Is it safe to drink alcohol while taking Silodosin?
Most people tolerate Silodosin well, and occasional alcoholic drinks should not affect the way this medicine works. However, alcohol can increase the risk of dizziness or fainting, especially when standing up quickly. It's best to limit alcohol consumption and be cautious when drinking while taking Silodosin. If you experience any unusual symptoms, consult your healthcare provider.
Is it safe to exercise while taking Silodosin?
Silodosin may cause dizziness or lightheadedness, especially when you first start taking it. This could potentially affect your ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities until you know how the medication affects you.
Is it safe to stop Silodosin?
Silodosin is typically used for managing symptoms of an ongoing condition, like benign prostatic hyperplasia (BPH). Stopping it suddenly might cause your symptoms to return or worsen. There are no known withdrawal symptoms, but it's important to consult your doctor before stopping. They can guide you on how to safely discontinue or adjust your medication.
Is Silodosin addictive?
Silodosin is not known to be addictive. It does not have habit-forming potential, so there is no risk of physical or psychological dependence. You can take it as prescribed without worrying about addiction. Always follow your doctor's instructions and discuss any concerns you have about your medication.
Is Silodosin safe for the elderly?
Elderly patients may experience orthostatic hypotension more frequently. It's important for them to rise slowly from sitting or lying positions to prevent dizziness or fainting. Regular monitoring by a healthcare provider is recommended to ensure safe use.
What are the most common side effects of Silodosin?
A side effect is an unwanted effect of a medicine. Common side effects of Silodosin include dizziness, diarrhea, nasal congestion, and retrograde ejaculation, which is when semen enters the bladder instead of exiting through the penis. These effects are usually mild and may go away over time. If you experience new or worsening symptoms, talk to your healthcare provider before stopping the medicine.
Who should avoid taking Silodosin?
Silodosin is contraindicated in patients with severe renal or hepatic impairment and those taking strong CYP3A4 inhibitors. It may cause orthostatic hypotension, so caution is advised when standing up quickly. Patients should inform their doctor if they have a history of low blood pressure or are undergoing eye surgery.
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