Silodosin
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Alpha-Adrenergic Blocker
Controlled Drug Substance
NO
Silodosin
Learn more about this medicine -
Click HereSummary
Silodosin is primarily used to treat symptoms of benign prostatic hyperplasia (BPH), a condition where the prostate gland enlarges, causing difficulty in urinating and frequent urination.
Silodosin works by blocking certain receptors in the prostate and bladder muscles. This causes the muscles to relax, improving urine flow and reducing BPH symptoms.
The usual adult dosage of Silodosin for BPH is 8 mg once daily, taken with food. It's important to swallow the capsule whole and not crush or chew it.
Common side effects of Silodosin include dizziness, ejaculation disorders, and headache. Less common but serious side effects can include low blood pressure, fainting, and severe allergic reactions.
Silodosin should be used with caution in people with a history of low blood pressure. It is not recommended for patients with severe liver or kidney impairment, or for those with a history of allergic reactions to alpha-blockers. It should also be avoided by those taking strong CYP3A4 inhibitors.
Indications and Purpose
What is Silodosin used for?
Silodosin is indicated for the treatment of symptoms associated with benign prostatic hyperplasia (BPH) in men, such as difficulty urinating, weak stream, and frequent urination.
How does Silodosin work?
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the prostate and bladder. By blocking these receptors, Silodosin relaxes smooth muscle in these tissues, improving urine flow and reducing BPH symptoms.
Is Silodosin effective?
Clinical studies have shown that Silodosin significantly improves symptoms of benign prostatic hyperplasia (BPH), such as urinary flow rate and International Prostate Symptom Score (IPSS). Patients reported symptom relief starting from the first scheduled observation and continuing through 12 weeks of treatment.
How does one know if Silodosin is working?
The benefit of Silodosin is evaluated by monitoring the improvement in symptoms of benign prostatic hyperplasia (BPH), such as urinary flow rate and the International Prostate Symptom Score (IPSS). Regular follow-ups with a healthcare provider help assess its effectiveness.
Directions for Use
What is the usual dose of Silodosin?
The usual daily dose for adults is 8 mg taken orally once a day with a meal. Silodosin is not indicated for use in children, so there is no recommended dose for pediatric patients.
How do I take Silodosin?
Silodosin should be taken once daily with a meal to ensure proper absorption and reduce the risk of side effects. Patients should discuss with their doctor about consuming grapefruit or grapefruit juice while on this medication.
For how long do I take Silodosin?
Silodosin is used to manage symptoms of benign prostatic hyperplasia (BPH) and is typically taken long-term. It does not cure BPH but helps control symptoms, so it should be continued as prescribed by a healthcare provider.
How long does it take for Silodosin to start working?
Silodosin can start improving symptoms of benign prostatic hyperplasia (BPH) from the first scheduled observation, with significant symptom relief observed within the first few days of treatment.
How should I store Silodosin?
Store Silodosin at room temperature, between 20°C to 25°C (68°F to 77°F), away from excess heat and moisture. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom.
Warnings and Precautions
Who should avoid taking Silodosin?
Silodosin is contraindicated in patients with severe renal or hepatic impairment and those taking strong CYP3A4 inhibitors. It may cause orthostatic hypotension, so caution is advised when standing up quickly. Patients should inform their doctor if they have a history of low blood pressure or are undergoing eye surgery.
Can I take Silodosin with other prescription drugs?
Silodosin should not be used with strong CYP3A4 inhibitors like ketoconazole, as they can increase Silodosin levels in the blood. Caution is advised when used with other alpha-blockers or PDE5 inhibitors, as they can cause symptomatic hypotension.
Can I take Silodosin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Silodosin be taken safely while pregnant?
Silodosin is not indicated for use in women, especially during pregnancy. There is no strong evidence from human studies on fetal harm, but it is advised that pregnant women avoid this medication.
Can Silodosin be taken safely while breastfeeding?
Silodosin is not indicated for use in women, including those who are breastfeeding. Therefore, it should not be used by breastfeeding mothers.
Is Silodosin safe for the elderly?
Elderly patients may experience orthostatic hypotension more frequently. It's important for them to rise slowly from sitting or lying positions to prevent dizziness or fainting. Regular monitoring by a healthcare provider is recommended to ensure safe use.
Is it safe to exercise while taking Silodosin?
Silodosin may cause dizziness or lightheadedness, especially when you first start taking it. This could potentially affect your ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities until you know how the medication affects you.
Is it safe to drink alcohol while taking Silodosin?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Forms / Brands
