Selpercatinib
Non-Small-Cell Lung Carcinoma, Thyroid Neoplasms
.svg)
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Selpercatinib
Summary
Selpercatinib is used to treat certain types of cancer, such as non-small cell lung cancer and thyroid cancer, which are cancers with specific genetic mutations. It helps slow down or stop the growth of cancer cells.
Selpercatinib works by blocking proteins called kinases, which are involved in the growth and spread of cancer cells. This action helps slow down or stop the progression of cancer.
The usual starting dose of Selpercatinib for adults is 160 mg taken twice daily. It is taken orally, which means by mouth, and can be taken with or without food.
Common side effects of Selpercatinib include fatigue, which is a feeling of tiredness, and stomach upset, which can include nausea and diarrhea. These effects are usually mild to moderate.
Selpercatinib can cause liver problems and high blood pressure, so regular monitoring is important. It is not recommended for pregnant or breastfeeding women due to potential risks to the baby.
Indications and Purpose
How does Selpercatinib work?
Selpercatinib works by blocking specific proteins called kinases, which are involved in the growth and spread of cancer cells. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, Selpercatinib helps slow down or stop the progression of cancer. This mechanism makes it effective for treating certain types of cancer with specific genetic mutations.
Is Selpercatinib effective?
Selpercatinib is effective in treating certain types of cancer, particularly those with specific genetic mutations. Clinical studies show it can shrink tumors and slow cancer progression. The effectiveness of Selpercatinib depends on the type of cancer and the presence of specific genetic markers. Your doctor will monitor your response to the medication through regular check-ups and tests.
What is Selpercatinib?
Selpercatinib is a medication used to treat certain types of cancer, particularly those with specific genetic mutations. It belongs to a class of drugs called kinase inhibitors, which work by blocking proteins that promote cancer cell growth. Selpercatinib is primarily used for cancers like non-small cell lung cancer and thyroid cancer. It can be used alone or in combination with other therapies, depending on the specific cancer type and patient needs.
Directions for Use
For how long do I take Selpercatinib?
Selpercatinib is usually a long-term medication for managing certain types of cancer. You'll typically take Selpercatinib every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Selpercatinib treatment.
How do I dispose of Selpercatinib?
If you can, bring unused Selpercatinib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Selpercatinib?
Take Selpercatinib as prescribed by your doctor, usually twice daily. You can take it with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not double up on doses. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Selpercatinib to start working?
Selpercatinib begins working in your body shortly after you take it, but the time to see noticeable effects can vary. Some patients may notice improvements in symptoms within a few weeks, while others may take longer. The full therapeutic effect may take several months. How quickly the medication works can depend on your specific cancer type, overall health, and response to treatment. Regular check-ups with your doctor will help monitor your progress.
How should I store Selpercatinib?
Store Selpercatinib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Always keep Selpercatinib out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Selpercatinib?
The usual starting dose of Selpercatinib for adults is 160 mg taken twice daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 160 mg twice daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can I take Selpercatinib with other prescription drugs?
Selpercatinib can interact with certain medications, including those that affect liver enzymes. These interactions can increase the risk of side effects or reduce the effectiveness of Selpercatinib. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions to ensure your treatment is safe and effective.
Can Selpercatinib be taken safely while breastfeeding?
Selpercatinib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it could potentially affect a nursing baby. If you're taking Selpercatinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Selpercatinib be taken safely while pregnant?
Selpercatinib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest it could harm fetal development. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Does Selpercatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Selpercatinib include dry mouth, diarrhea, and fatigue. Serious side effects can include liver problems and high blood pressure. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Selpercatinib and recommend appropriate action.
Does Selpercatinib have any safety warnings?
Yes, Selpercatinib has important safety warnings. It can cause liver problems, so regular liver function tests are needed. It may also cause high blood pressure, so monitor your blood pressure regularly. If you experience symptoms like yellowing of the skin or eyes, severe fatigue, or unusual bleeding, contact your doctor immediately. Always follow your doctor's advice and report any new symptoms.
Is it safe to drink alcohol while taking Selpercatinib?
It's best to avoid alcohol while taking Selpercatinib. Alcohol can increase the risk of liver problems, which is a potential side effect of Selpercatinib. Drinking alcohol may also worsen other side effects like dizziness or fatigue. Talk with your doctor about alcohol use while taking Selpercatinib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Selpercatinib?
You can exercise while taking Selpercatinib, but keep a few things in mind. This medication can cause fatigue or dizziness, which might affect your ability to exercise. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Drink plenty of water before, during, and after physical activity. If you notice any unusual symptoms, slow down or stop exercising and rest.
Is it safe to stop Selpercatinib?
Stopping Selpercatinib suddenly can affect your treatment. If you're taking it for cancer, stopping could allow the cancer to progress. Always talk with your doctor before stopping Selpercatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
Is Selpercatinib addictive?
Selpercatinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Selpercatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Selpercatinib, such as liver problems and high blood pressure. Regular monitoring by a healthcare provider is important to ensure safety. Dose adjustments may be necessary based on individual health conditions. Always consult your doctor about any concerns and inform them of your medical history before starting Selpercatinib.
What are the most common side effects of Selpercatinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Selpercatinib include dry mouth, diarrhea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Selpercatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Selpercatinib?
Don't take Selpercatinib if you're allergic to it or its ingredients. It should be used with caution in people with severe liver problems. Selpercatinib may not be suitable for pregnant or breastfeeding women due to potential risks to the baby. Always consult your doctor about any concerns and inform them of your medical history before starting Selpercatinib.
