Selinexor
Multiple Myeloma
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Nuclear Export Inhibitor
Controlled Drug Substance
No
selinexor
Summary
Selinexor is used to treat certain types of cancer, including multiple myeloma, which is a cancer of plasma cells, and diffuse large B-cell lymphoma, which is a type of non-Hodgkin lymphoma. It helps slow the growth and spread of cancer cells.
Selinexor works by blocking a protein called XPO1, which helps cancer cells grow and survive. By inhibiting this protein, Selinexor prevents cancer cells from multiplying and spreading, effectively slowing down the progression of cancer.
The usual starting dose of Selinexor for adults is 80 mg taken once weekly. It is taken orally, which means by mouth, and should be swallowed whole with water. Your doctor may adjust the dose based on your response and any side effects.
Common side effects of Selinexor include nausea, which is a feeling of sickness with an inclination to vomit, fatigue, which is extreme tiredness, and decreased appetite, which means a reduced desire to eat. These effects are usually mild to moderate.
Selinexor can cause low blood cell counts, increasing infection risk. It is not recommended for those with severe liver problems. Always inform your doctor about your medical history to assess risks and benefits. Avoid use if allergic to Selinexor or its ingredients.
Indications and Purpose
How does Selinexor work?
Selinexor works by blocking a protein called XPO1, which helps cancer cells grow and survive. By inhibiting this protein, Selinexor prevents cancer cells from multiplying and spreading. Think of it like closing a door to stop unwanted guests from entering. This action helps slow down the progression of cancer. Selinexor is used to treat certain types of cancer, often in combination with other treatments to enhance its effectiveness.
Is Selinexor effective?
Selinexor is effective for treating certain types of cancer, such as multiple myeloma and diffuse large B-cell lymphoma. It works by blocking a protein that helps cancer cells grow. Clinical studies show Selinexor can improve health outcomes in patients with these conditions. It is often used in combination with other cancer treatments. Your doctor will monitor your response to Selinexor to ensure it is working effectively for your condition.
What is Selinexor?
Selinexor is a medication used to treat certain types of cancer, such as multiple myeloma and diffuse large B-cell lymphoma. It belongs to a class of drugs called selective inhibitors of nuclear export, which work by blocking a protein that helps cancer cells grow. Selinexor is often used in combination with other cancer treatments to improve outcomes. Your doctor will determine if Selinexor is appropriate for your specific condition.
Directions for Use
For how long do I take Selinexor?
Selinexor is usually taken long-term for chronic conditions like cancer. The duration of use depends on your response to treatment and any side effects. Your doctor will determine how long you need to take Selinexor based on your health condition. Always follow your doctor's instructions and discuss any concerns about your treatment duration with them. Do not stop taking Selinexor without medical advice.
How do I dispose of Selinexor?
Dispose of Selinexor through a drug take-back program or collection site at a pharmacy or hospital. This ensures safe disposal without harming people or the environment. If a take-back program isn't available, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. Always keep medications out of reach of children and pets.
How do I take Selinexor?
Take Selinexor exactly as prescribed by your doctor. It's usually taken once a week, on the same day each week. Swallow the tablet whole with water; do not crush or chew it. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not double up on doses. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Selinexor to start working?
Selinexor starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to appear. The time it takes to see results can vary based on your condition and overall health. Your doctor will monitor your progress with regular tests and check-ups. It's important to take Selinexor exactly as prescribed for the best results. Discuss any concerns about the medication's effectiveness with your doctor.
How should I store Selinexor?
Store Selinexor at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in humid places like bathrooms. Always keep Selinexor out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication. Follow any specific storage instructions provided by your pharmacist or doctor.
What is the usual dose of Selinexor?
The usual starting dose of Selinexor for adults is 80 mg taken once weekly. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 100 mg per week. Dose adjustments may be necessary for elderly patients or those with specific health conditions. Always follow your doctor's dosing instructions and discuss any concerns about your dosage with them.
Warnings and Precautions
Can I take Selinexor with other prescription drugs?
Selinexor can interact with other medications, increasing the risk of adverse effects. It's important to inform your doctor about all the medications you take, including over-the-counter drugs and supplements. Your doctor will assess potential interactions and adjust your treatment plan if necessary. Always follow your doctor's advice to ensure safe and effective use of Selinexor.
Can Selinexor be taken safely while breastfeeding?
Selinexor is not recommended while breastfeeding. There is limited information on whether it passes into breast milk. Potential risks to the breastfed infant are unknown. If you are breastfeeding or planning to breastfeed, discuss your treatment options with your doctor. They can help you choose a safer medication that allows you to nurse your baby safely. Always inform your healthcare provider about your breastfeeding status.
Can Selinexor be taken safely while pregnant?
Selinexor is not recommended during pregnancy. There is limited evidence on its safety for pregnant women. Animal studies suggest potential risks to the developing fetus. If you are pregnant or planning to become pregnant, discuss your treatment options with your doctor. They can help create a plan that ensures the safety of both you and your baby. Always inform your healthcare provider if you become pregnant while taking Selinexor.
Does Selinexor have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Selinexor include nausea, fatigue, and low blood cell counts. These effects vary in frequency and severity. Serious side effects, like severe infections or bleeding, require immediate medical attention. Always inform your doctor about any new or worsening symptoms. They can help manage side effects and adjust your treatment if necessary.
Does Selinexor have any safety warnings?
Yes, Selinexor has important safety warnings. It can cause low blood cell counts, which may increase infection risk. It may also cause nausea, vomiting, and fatigue. Not following safety warnings can lead to serious health issues. Always adhere to your doctor's instructions and report any unusual symptoms. Regular blood tests may be needed to monitor your health while on Selinexor.
Is it safe to drink alcohol while taking Selinexor?
It's best to avoid alcohol while taking Selinexor. Alcohol can worsen side effects like nausea and dizziness. It may also affect your liver, which is important for processing medications. If you choose to drink, limit your intake and watch for warning signs like increased side effects. Discuss alcohol use with your doctor to get personalized advice based on your health situation. They can help you make safe choices while on Selinexor.
Is it safe to exercise while taking Selinexor?
You can exercise while taking Selinexor, but be cautious. This medication can cause fatigue and dizziness, which may affect your exercise capacity. Listen to your body and avoid strenuous activities if you feel unwell. Stay hydrated and take breaks as needed. If you experience unusual symptoms during exercise, stop and rest. Discuss your exercise routine with your doctor to ensure it's safe and appropriate for your health condition.
Is it safe to stop Selinexor?
Stopping Selinexor suddenly can affect your treatment. It's used long-term for chronic conditions like cancer. Stopping without medical advice may worsen your condition. Always talk with your doctor before stopping Selinexor. They might suggest a gradual reduction or alternative treatment to manage your condition safely. Your doctor will guide you on any medication changes to protect your health.
Is Selinexor addictive?
Selinexor is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms. The medication works by affecting cancer cells, not brain chemistry, so it doesn't lead to addiction. You won't feel compelled to take more than prescribed. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance on managing your treatment.
Is Selinexor safe for the elderly?
Elderly patients may experience a higher incidence of adverse reactions when taking Selinexor. In clinical studies, patients aged 65 and older had a higher rate of treatment discontinuation due to adverse reactions and a higher incidence of serious adverse reactions compared to younger patients. It is important for elderly patients to be closely monitored by their healthcare provider, and any side effects should be reported promptly to ensure safe use of the medication.
What are the most common side effects of Selinexor?
Side effects are unwanted reactions to a medication. Common side effects of Selinexor include nausea, fatigue, and decreased appetite. These occur in a significant number of patients. If you experience new symptoms after starting Selinexor, they might be temporary or unrelated. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Selinexor and suggest ways to manage them.
Who should avoid taking Selinexor?
Do not use Selinexor if you are allergic to it or its ingredients. It is contraindicated in patients with severe liver problems. Caution is needed for those with low blood cell counts or infections. Always inform your doctor about your medical history before starting Selinexor. They will assess the risks and benefits to ensure safe use. Follow your doctor's advice to avoid potential complications.
