Selegiline
Parkinson Disease, Schizophrenia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Monoamine Oxidase Inhibitor and Monoamine Oxidase Type B Inhibitor
Controlled Drug Substance
No
Selegiline
Summary
Selegiline is used to treat Parkinson's disease, which affects movement. It helps improve symptoms like tremors and stiffness. It can also be used for major depressive disorder in some cases.
Selegiline works by inhibiting an enzyme called MAO-B, which breaks down dopamine in the brain. This increases dopamine levels, improving motor symptoms in Parkinson's disease.
The usual starting dose for adults is 5 mg taken twice daily, at breakfast and lunch. The maximum recommended dose is 10 mg per day. Always follow your doctor's instructions.
Common side effects include nausea, dizziness, and dry mouth. These effects vary in frequency and severity. Serious side effects like high blood pressure require immediate medical attention.
Selegiline can increase the risk of serotonin syndrome, which is a serious condition. It should not be taken with other MAO inhibitors or certain antidepressants. Always inform your doctor about all medications you take.
Indications and Purpose
How does Selegiline work?
Selegiline works by inhibiting an enzyme called MAO-B, which breaks down dopamine in the brain. By blocking this enzyme, Selegiline increases dopamine levels, which helps improve motor symptoms in Parkinson's disease. Think of it like a dam holding back water; Selegiline helps keep more dopamine "water" in the brain "reservoir," improving movement control. This mechanism makes it effective for managing Parkinson's symptoms.
Is Selegiline effective?
Selegiline is effective in treating Parkinson's disease, which is a condition that affects movement. It works by increasing dopamine levels in the brain, which helps improve motor symptoms. Clinical studies show that Selegiline can reduce the need for other Parkinson's medications and improve quality of life. It is often used in combination with other treatments to enhance its effectiveness. Always follow your doctor's advice to achieve the best results.
What is Selegiline?
Selegiline is a medication used to treat Parkinson's disease, which affects movement. It belongs to a class of drugs called MAO-B inhibitors, which work by increasing dopamine levels in the brain. This helps improve motor symptoms like tremors and stiffness. Selegiline is often used in combination with other Parkinson's medications to enhance its effectiveness. It can also be used to treat major depressive disorder in some cases.
Directions for Use
For how long do I take Selegiline?
Selegiline is usually a long-term medication for managing Parkinson's disease, which affects movement. You'll typically take it every day as part of your ongoing treatment plan. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Selegiline treatment. They can provide guidance on managing your condition safely.
How do I dispose of Selegiline?
Dispose of Selegiline by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Selegiline?
Take Selegiline as prescribed by your doctor. It's usually taken once daily, either in the morning or at noon. You can take it with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Avoid taking two doses at once. Follow any dietary or beverage restrictions your doctor advises while on this medication.
How long does it take for Selegiline to start working?
Selegiline starts working in your body shortly after you take it, but you may not notice all the benefits right away. For Parkinson's disease, you might see some improvement in motor symptoms within a few weeks. The full therapeutic effect can take several weeks to months. How quickly it works can depend on your overall health and other medications you are taking. Take it exactly as prescribed for the best results.
How should I store Selegiline?
Store Selegiline at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Selegiline out of children's reach to prevent accidental swallowing.
What is the usual dose of Selegiline?
The usual starting dose of Selegiline for adults is 5 mg taken twice daily, at breakfast and lunch. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 10 mg per day. For elderly patients, careful monitoring is needed. Always follow your doctor's specific dosing instructions for your health needs. Do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can I take Selegiline with other prescription drugs?
Selegiline has important drug interactions to be aware of. It should not be taken with other MAO inhibitors or certain antidepressants, as this can lead to serotonin syndrome, which is a serious condition. Interactions with certain pain medications and decongestants can also cause high blood pressure. Always inform your doctor about all medications you are taking to avoid harmful interactions. They can help manage your treatment safely.
Can Selegiline be taken safely while breastfeeding?
Selegiline is not recommended while breastfeeding due to limited information on its safety. It's unclear if the medication passes into breast milk or affects milk production. The potential risks to a breastfed infant are not well understood. If you're taking Selegiline and want to breastfeed, discuss safer medication options with your doctor. They can help you find a treatment plan that allows you to nurse your baby safely.
Can Selegiline be taken safely while pregnant?
Selegiline is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but human data is lacking. Uncontrolled Parkinson's disease during pregnancy can cause complications for both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. They can help create a treatment plan that protects both you and your baby.
Does Selegiline have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Selegiline include nausea, dizziness, and dry mouth. These effects vary in frequency and severity. Serious side effects can include high blood pressure and serotonin syndrome, which require immediate medical attention. If you experience any new or worsening symptoms, contact your doctor. They can help determine if these are related to Selegiline and adjust your treatment as needed.
Does Selegiline have any safety warnings?
Yes, Selegiline has important safety warnings. It can increase the risk of serotonin syndrome, which is a serious condition caused by too much serotonin in the brain. Symptoms include confusion, agitation, and rapid heart rate. Selegiline can also interact with certain foods and medications, leading to high blood pressure. Always follow dietary restrictions and inform your doctor about all medications you take. Not adhering to these warnings can lead to severe health issues.
Is it safe to drink alcohol while taking Selegiline?
It's best to avoid alcohol while taking Selegiline. Alcohol can increase the risk of side effects like dizziness and high blood pressure. It may also interfere with the medication's effectiveness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Selegiline to get personalized advice based on your health situation.
Is it safe to exercise while taking Selegiline?
You can exercise while taking Selegiline, but be cautious. This medication can cause dizziness or low blood pressure, which might affect your ability to exercise safely. Start with light activities and gradually increase intensity. Stay hydrated and watch for signs of dizziness or fatigue. If you experience these symptoms, stop exercising and rest. Consult your doctor about your exercise routine to ensure it's safe with your medication.
Is it safe to stop Selegiline?
Stopping Selegiline suddenly can worsen symptoms of Parkinson's disease, which is a condition that affects movement. It's important to talk with your doctor before stopping the medication. They may suggest gradually reducing your dose to avoid withdrawal symptoms and keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
Is Selegiline addictive?
Selegiline is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Selegiline works by affecting brain chemicals to help manage symptoms of Parkinson's disease. It doesn't affect brain chemistry in a way that leads to addiction. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance on managing your treatment safely.
Is Selegiline safe for the elderly?
Elderly individuals are more vulnerable to medication side effects due to age-related changes in the body. Selegiline is generally safe for the elderly, but they may experience more pronounced side effects like dizziness or low blood pressure. Careful monitoring and dose adjustments may be necessary. Always consult with a healthcare provider to ensure the medication is appropriate and safe for elderly patients.
What are the most common side effects of Selegiline?
Side effects are unwanted reactions to a medication. Common side effects of Selegiline include nausea, dizziness, and dry mouth. These occur in a small percentage of people. If you experience new symptoms after starting Selegiline, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. They can help determine if the side effects are related to Selegiline and provide guidance on managing them.
Who should avoid taking Selegiline?
Selegiline should not be used if you are allergic to it or its ingredients. It's contraindicated with certain medications like other MAO inhibitors, which can cause dangerous interactions. People with pheochromocytoma, which is a rare tumor, should avoid it. Caution is needed if you have high blood pressure or are taking antidepressants. Always consult your doctor about your medical history and current medications before starting Selegiline.
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