Rucaparib
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Poly(ADP-Ribose) Polymerase Inhibitor
Controlled Drug Substance
No
rucaparib
Summary
Rucaparib is used to treat certain types of ovarian cancer, which is a cancer that begins in the ovaries. It may also be used for other cancers as determined by your doctor.
Rucaparib works by inhibiting PARP enzymes, which are proteins that help repair damaged DNA in cells. By blocking these enzymes, Rucaparib prevents cancer cells from repairing themselves, leading to their death.
The usual starting dose of Rucaparib for adults is 600 mg taken twice daily, which means two times a day. It is taken orally, which means by mouth, with or without food.
Common side effects of Rucaparib include nausea, which is feeling sick to your stomach, fatigue, which is feeling very tired, and anemia, which is a condition where you have fewer red blood cells than normal.
Rucaparib can cause bone marrow problems, which affect blood cell production, and liver issues, which affect liver function. It should not be used if you have a known allergy to it or its ingredients.
Indications and Purpose
How does Rucaparib work?
Rucaparib works by inhibiting PARP enzymes, which help repair damaged DNA in cells. By blocking these enzymes, Rucaparib prevents cancer cells from repairing themselves, leading to their death. This process is similar to cutting off a lifeline for cancer cells, making it harder for them to survive. Rucaparib is effective in treating certain types of ovarian cancer by targeting these repair mechanisms.
Is Rucaparib effective?
Rucaparib is effective in treating certain types of ovarian cancer. It works by inhibiting enzymes that help repair DNA in cancer cells, leading to their death. Clinical studies show Rucaparib can improve progression-free survival in patients with ovarian cancer. This means it can help delay the growth of cancer. Your doctor will monitor your response to Rucaparib through regular check-ups and tests to ensure it's working effectively for you.
What is Rucaparib?
Rucaparib is a medication used to treat certain types of ovarian cancer. It belongs to a class of drugs called PARP inhibitors, which work by blocking enzymes that help repair DNA in cancer cells. This leads to the death of cancer cells. Rucaparib is primarily used for ovarian cancer but may also be used for other cancers as determined by your doctor. It is often used in combination with other therapies to enhance its effectiveness.
Directions for Use
For how long do I take Rucaparib?
Rucaparib is usually taken long-term for managing ovarian cancer. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will guide you on how long to continue Rucaparib based on your specific health needs. Always talk with your doctor before changing or stopping your Rucaparib treatment.
How do I dispose of Rucaparib?
Dispose of unused Rucaparib through a drug take-back program or collection site at a pharmacy or hospital. This ensures safe disposal without harming people or the environment. If a take-back program isn't available, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. Always keep medications out of reach of children and pets.
How do I take Rucaparib?
Take Rucaparib as prescribed by your doctor, usually twice daily, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow any dietary or beverage restrictions your doctor advises while on this medication.
How long does it take for Rucaparib to start working?
Rucaparib starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to become apparent. The time it takes to see results can vary based on individual factors like your overall health and the specific cancer being treated. Regular check-ups and tests with your doctor will help monitor the effectiveness of Rucaparib in your treatment plan.
How should I store Rucaparib?
Store Rucaparib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in humid places like bathrooms. Always keep Rucaparib out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Rucaparib?
The usual starting dose of Rucaparib for adults is 600 mg taken twice daily. Your doctor may adjust the dose based on your response and any side effects. It's important to follow your doctor's specific dosing instructions. Rucaparib is not typically used in children, and elderly patients may require careful monitoring. Always consult your healthcare provider for personalized dosing guidance.
Warnings and Precautions
Can I take Rucaparib with other prescription drugs?
Rucaparib can interact with other medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan as needed. Always follow your healthcare provider's advice to ensure safe and effective use of Rucaparib.
Can Rucaparib be taken safely while breastfeeding?
Rucaparib is not recommended while breastfeeding. It's unclear if it passes into human breast milk, but it could pose risks to a nursing infant. If you're taking Rucaparib and want to breastfeed, discuss safer medication options with your doctor. They can help you find a treatment plan that allows you to nurse your baby safely.
Can Rucaparib be taken safely while pregnant?
Rucaparib is not recommended during pregnancy. It can harm an unborn baby. There is limited information on its use in pregnant women, but animal studies suggest potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a plan that protects both you and your baby.
Does Rucaparib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Rucaparib include nausea, fatigue, and anemia. These occur in more than 10% of patients. Serious side effects can include bone marrow problems and liver issues. If you notice symptoms like unusual bleeding or yellowing of the skin, contact your doctor immediately. Always inform your healthcare provider about any new or worsening symptoms while taking Rucaparib.
Does Rucaparib have any safety warnings?
Yes, Rucaparib has important safety warnings. It can cause bone marrow problems, leading to low blood cell counts. This increases the risk of infections, bleeding, and anemia. Regular blood tests are needed to monitor these effects. Rucaparib may also cause liver problems, so liver function tests are important. If you experience symptoms like unusual bleeding, bruising, or yellowing of the skin, contact your doctor immediately. Adhering to these safety warnings is crucial to avoid serious health issues.
Is it safe to drink alcohol while taking Rucaparib?
It's best to avoid alcohol while taking Rucaparib. Alcohol can increase the risk of liver problems, which Rucaparib can also cause. Drinking alcohol may worsen side effects like nausea or dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Discuss alcohol use with your doctor to get personalized advice based on your health situation.
Is it safe to exercise while taking Rucaparib?
You can exercise while taking Rucaparib, but be mindful of your body's response. Rucaparib can cause fatigue, which might affect your exercise capacity. If you feel unusually tired or dizzy during physical activity, slow down or stop and rest. Drink plenty of water to stay hydrated. Consult your doctor if you have concerns about exercising while on Rucaparib.
Is it safe to stop Rucaparib?
Stopping Rucaparib suddenly can affect your cancer treatment. It's important to follow your doctor's advice on how long to take it. If you stop Rucaparib without medical guidance, your cancer may progress. Always talk with your doctor before stopping Rucaparib. They might suggest a gradual reduction or an alternative treatment to ensure your condition remains under control.
Is Rucaparib addictive?
Rucaparib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Rucaparib works by inhibiting certain enzymes in cancer cells, which does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Rucaparib does not carry this risk.
Is Rucaparib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Rucaparib, such as fatigue and anemia. These effects can be more pronounced in older adults. Regular monitoring by a healthcare provider is important to ensure safety. If you are elderly and taking Rucaparib, discuss any concerns with your doctor. They can help manage side effects and adjust your treatment as needed.
What are the most common side effects of Rucaparib?
Side effects are unwanted reactions to a medication. Common side effects of Rucaparib include nausea, fatigue, and anemia, affecting more than 10% of patients. These symptoms can vary in severity. If you experience new symptoms after starting Rucaparib, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication to ensure your treatment remains effective.
Who should avoid taking Rucaparib?
Rucaparib should not be used if you have a known allergy to it or its ingredients. Serious allergic reactions require immediate medical help. Caution is needed if you have liver or kidney problems, as Rucaparib can affect these organs. Always inform your doctor about your medical history and any other medications you are taking. This helps ensure Rucaparib is safe and effective for you.
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