Riociguat
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Soluble Guanylate Cyclase Stimulator
Controlled Drug Substance
No
riociguat
Summary
Riociguat is used to treat pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, which are conditions characterized by high blood pressure in the lungs.
Riociguat works by stimulating an enzyme called soluble guanylate cyclase, which helps relax blood vessels in the lungs, improving blood flow and reducing blood pressure.
The usual starting dose of Riociguat for adults is 1 mg taken three times a day. The maximum recommended dose is 2.5 mg three times a day. It is taken orally, with or without food.
Common side effects of Riociguat include headache, dizziness, and indigestion, which refers to discomfort in the stomach area.
Riociguat should not be taken with nitrates or nitric oxide donors, which can cause a dangerous drop in blood pressure. It is also not safe during pregnancy as it can harm the unborn baby.
Indications and Purpose
How does Riociguat work?
Riociguat works by stimulating an enzyme called soluble guanylate cyclase, which helps relax blood vessels in the lungs. This relaxation improves blood flow and reduces blood pressure. Think of it like opening a valve to allow more water to flow through a pipe. This action helps improve exercise capacity and delay disease progression in pulmonary hypertension.
Is Riociguat effective?
Riociguat is effective for treating pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. It works by relaxing blood vessels in the lungs, improving blood flow, and reducing blood pressure. Clinical studies show Riociguat improves exercise capacity and delays disease progression. Always follow your doctor's instructions to achieve the best results.
What is Riociguat?
Riociguat is a medication used to treat pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. It belongs to a class of drugs called soluble guanylate cyclase stimulators. Riociguat works by relaxing blood vessels in the lungs, improving blood flow, and reducing blood pressure. This helps improve exercise capacity and delay disease progression.
Directions for Use
For how long do I take Riociguat?
Riociguat is usually a long-term medication for managing pulmonary hypertension. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Riociguat treatment.
How do I dispose of Riociguat?
Dispose of Riociguat by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Riociguat?
Take Riociguat exactly as prescribed by your doctor. It's usually taken three times a day, with or without food. Swallow the tablet whole; do not crush or split it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Do not take two doses at once. Avoid grapefruit juice while taking Riociguat, as it can affect how the medicine works.
How long does it take for Riociguat to start working?
Riociguat starts working shortly after you take it, but you may not notice all the benefits right away. Improvement in symptoms like shortness of breath may be seen within weeks. Full therapeutic effects, such as increased exercise capacity, may take several months. How quickly it works can depend on your overall health and response to treatment.
How should I store Riociguat?
Store Riociguat at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always keep Riociguat out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Riociguat?
The usual starting dose of Riociguat for adults is 1 mg taken three times a day. Your doctor may adjust your dose based on your response and tolerance. The maximum recommended dose is 2.5 mg three times a day. Always follow your doctor's specific dosing instructions. Special populations, such as the elderly, may require different dosing adjustments.
Warnings and Precautions
Can I take Riociguat with other prescription drugs?
Major interactions with Riociguat include nitrates and nitric oxide donors, which can cause a dangerous drop in blood pressure. Moderate interactions may occur with certain antifungal and antibiotic medications. These interactions can increase the risk of adverse effects or reduce the effectiveness of Riociguat. Always inform your doctor about all medications you are taking to avoid potential interactions.
Can Riociguat be taken safely while breastfeeding?
Riociguat is not recommended while breastfeeding. We don't have enough information about whether it passes into human breast milk or its effects on the breastfed infant. If you're taking Riociguat and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Riociguat be taken safely while pregnant?
Riociguat is not safe during pregnancy. It can harm the unborn baby, so it's important to use effective birth control while taking it. If you become pregnant while on Riociguat, contact your doctor immediately. They will discuss alternative treatments and help manage your condition safely during pregnancy.
Does Riociguat have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Riociguat include headache, dizziness, and indigestion. Serious side effects can include low blood pressure and bleeding. If you experience any severe or persistent symptoms, contact your doctor immediately. Always inform your healthcare provider about any new or worsening symptoms while taking Riociguat.
Does Riociguat have any safety warnings?
Yes, Riociguat has important safety warnings. It can cause low blood pressure, which may lead to dizziness or fainting. Avoid using Riociguat with nitrates or nitric oxide donors, as this can cause a dangerous drop in blood pressure. If you experience symptoms like chest pain, shortness of breath, or fainting, seek medical help immediately. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Riociguat?
It's best to avoid alcohol while taking Riociguat. Alcohol can increase the risk of low blood pressure, which may cause dizziness or fainting. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or lightheadedness. Talk with your doctor about alcohol use while taking Riociguat for personalized advice.
Is it safe to exercise while taking Riociguat?
You can exercise while taking Riociguat, but be cautious. This medication can cause low blood pressure, leading to dizziness during physical activity. To exercise safely, stay hydrated and avoid strenuous activities if you feel dizzy. If you experience unusual symptoms, stop exercising and rest. Consult your doctor if you have concerns about your exercise routine.
Is it safe to stop Riociguat?
Stopping Riociguat suddenly can cause your condition to worsen. It's used long-term for conditions like pulmonary hypertension. If you stop taking it, symptoms may return or worsen. Always talk with your doctor before stopping Riociguat. They may suggest gradually reducing your dose or switching to another medication to manage your condition safely.
Is Riociguat addictive?
Riociguat is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Riociguat works by affecting blood vessels to improve blood flow, and this mechanism does not lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, discuss them with your doctor.
Is Riociguat safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Riociguat, such as low blood pressure and dizziness. It's important for older adults to be closely monitored by their doctor while taking this medication. Dose adjustments may be necessary based on individual health conditions and response to treatment.
What are the most common side effects of Riociguat?
Side effects are unwanted reactions that can occur with medication use. Common side effects of Riociguat include headache, dizziness, and indigestion. These effects vary from person to person. If you notice new symptoms after starting Riociguat, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Riociguat?
Do not take Riociguat if you're pregnant, as it can harm the unborn baby. It's also contraindicated with nitrates or nitric oxide donors, which can cause a dangerous drop in blood pressure. People with severe liver impairment should avoid it. Always consult your doctor about any concerns or conditions before starting Riociguat.
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