Regorafenib
Hepatocellular Carcinoma, Colorectal Neoplasms ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Regorafenib
Summary
Regorafenib is used to treat certain types of cancer, such as colorectal cancer and gastrointestinal stromal tumors, which are growths in the digestive tract. It is typically prescribed when other treatments have not been effective.
Regorafenib works by blocking proteins called kinases, which help cancer cells grow. By stopping these proteins, it slows down the growth of cancer and can shrink tumors.
The usual dose for adults is 160 mg taken once daily for 21 days, followed by a 7-day break. This cycle repeats every 28 days. It is taken orally, which means by mouth, with a low-fat meal.
Common side effects include fatigue, which is feeling very tired, diarrhea, which is frequent loose stools, and hand-foot skin reactions, which are redness and swelling on the palms and soles.
Regorafenib can cause severe liver damage, which is harm to the liver, and increase bleeding risk. It should not be used if you have severe liver problems or are allergic to its ingredients.
Indications and Purpose
How does Regorafenib work?
Regorafenib works by blocking certain proteins called kinases, which are involved in cancer cell growth and survival. Think of it like turning off a switch that cancer cells need to grow. By inhibiting these proteins, Regorafenib helps slow the progression of cancer and can shrink tumors. This action makes it effective for treating certain types of cancer, such as colorectal cancer and gastrointestinal stromal tumors. Always follow your doctor's instructions when taking Regorafenib.
Is Regorafenib effective?
Regorafenib is effective in treating certain types of cancer, such as colorectal cancer and gastrointestinal stromal tumors. It works by blocking proteins that promote cancer cell growth. Clinical studies show Regorafenib can slow disease progression and improve survival rates in some patients. The effectiveness can vary based on individual health conditions and cancer type. Regular monitoring by your doctor will help assess how well Regorafenib is working for you.
What is Regorafenib?
Regorafenib is a medication used to treat certain types of cancer, such as colorectal cancer and gastrointestinal stromal tumors. It belongs to a class of drugs called kinase inhibitors, which work by blocking proteins that promote cancer cell growth. Regorafenib helps slow the progression of cancer and can improve survival rates in some patients. It's usually used when other treatments have not been effective. Always follow your doctor's instructions when taking Regorafenib.
Directions for Use
For how long do I take Regorafenib?
Regorafenib is usually taken long-term for managing certain cancers. The duration of use depends on your response to treatment and any side effects you experience. Your doctor will regularly assess your condition to determine how long you should continue taking Regorafenib. It's important to follow your doctor's advice and not stop the medication without consulting them, as this could affect your treatment outcome.
How do I dispose of Regorafenib?
To dispose of Regorafenib, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. Always keep medicines out of reach of children and pets.
How do I take Regorafenib?
Take Regorafenib exactly as your doctor prescribes. Usually, it's taken once daily. Swallow the tablet whole with water after a low-fat meal. Do not crush or chew the tablet. Avoid grapefruit and grapefruit juice, as they can interfere with the medicine. If you miss a dose, take it as soon as you remember, unless it's close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Never take two doses at once. Always follow your doctor's specific instructions for the best results.
How long does it take for Regorafenib to start working?
Regorafenib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual health conditions and cancer type. Regular monitoring by your doctor will help assess how well Regorafenib is working for you. It's important to take it exactly as prescribed for the best results.
How should I store Regorafenib?
Store Regorafenib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Always keep it out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Regorafenib?
The usual starting dose of Regorafenib for adults is 160 mg taken once daily for 21 days, followed by a 7-day break. This cycle is repeated every 28 days. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 160 mg per day. Regorafenib is not typically used in children. Elderly patients may require careful monitoring. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can I take Regorafenib with other prescription drugs?
Regorafenib can interact with other medications, increasing the risk of adverse effects or reducing its effectiveness. For example, it can interact with blood thinners, increasing bleeding risk. It may also interact with certain antibiotics and antifungal medications. Always inform your doctor about all the medications you are taking to avoid potential interactions. They can adjust your treatment plan to ensure safety and effectiveness.
Can Regorafenib be taken safely while breastfeeding?
Regorafenib is not recommended while breastfeeding. It's unclear if it passes into human breast milk, but it could pose risks to a nursing infant. The effects on milk supply are also unknown. If you're taking Regorafenib and want to breastfeed, talk with your doctor about safer medication options. They can help you find a treatment that allows you to nurse your baby safely.
Can Regorafenib be taken safely while pregnant?
Regorafenib is not recommended during pregnancy. It can harm an unborn baby. There is limited information on its safety in pregnant women, but animal studies show potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. They can help create a plan that protects both you and your baby. Always inform your doctor if you become pregnant while taking Regorafenib.
Does Regorafenib have adverse effects?
Adverse effects are unwanted reactions to a medication. Regorafenib can cause side effects like fatigue, hand-foot skin reactions, and diarrhea, which are common. Serious adverse effects include liver damage and severe bleeding. If you notice symptoms like yellowing skin or unusual bleeding, seek medical help immediately. Always inform your doctor about any new or worsening symptoms while taking Regorafenib. They can help determine if these are related to the medication and suggest appropriate actions.
Does Regorafenib have any safety warnings?
Yes, Regorafenib has important safety warnings. It can cause severe liver damage, which may be life-threatening. Regular liver function tests are necessary. It may also increase the risk of bleeding and cause high blood pressure. Not following these warnings can lead to serious health issues. If you experience symptoms like yellowing of the skin, unusual bleeding, or severe headaches, seek medical help immediately. Always adhere to your doctor's advice and report any concerning symptoms.
Is it safe to drink alcohol while taking Regorafenib?
It's best to avoid alcohol while taking Regorafenib. Alcohol can increase the risk of liver damage, which is a serious side effect of Regorafenib. Drinking alcohol may also worsen other side effects like fatigue or dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or unusual tiredness. Talk with your doctor about alcohol use while taking Regorafenib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Regorafenib?
You can exercise while taking Regorafenib, but be cautious. This medication can cause fatigue and increase the risk of dehydration. These effects might make you feel dizzy or lightheaded during exercise. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Regorafenib?
Stopping Regorafenib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice may cause your condition to worsen. There are no known withdrawal symptoms, but always talk with your doctor before stopping. They might suggest a gradual reduction or an alternative treatment to ensure your condition remains under control. Your doctor will help you make any medication changes safely to protect your health.
Is Regorafenib addictive?
Regorafenib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Regorafenib works by inhibiting certain proteins involved in cancer cell growth, and this mechanism does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Regorafenib doesn't carry this risk while managing your health condition.
Is Regorafenib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Regorafenib, such as liver damage and high blood pressure. They may also have other health conditions that require careful monitoring. Regorafenib can be used in the elderly, but with caution. Regular check-ups and dose adjustments may be necessary to ensure safety. Always consult your doctor about the risks and benefits of using Regorafenib if you are elderly.
What are the most common side effects of Regorafenib?
Side effects are unwanted reactions to a medication. Common side effects of Regorafenib include fatigue, diarrhea, and hand-foot skin reactions, which affect more than 10% of people. These side effects can vary in severity. If you experience new symptoms after starting Regorafenib, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. They can help determine if the side effects are related to Regorafenib and suggest ways to manage them.
Who should avoid taking Regorafenib?
Regorafenib should not be used if you have severe liver problems, as it can worsen liver function. It's also contraindicated if you're allergic to any of its ingredients. Caution is needed if you have a history of bleeding disorders or high blood pressure. Always inform your doctor about your medical history before starting Regorafenib. They can assess the risks and benefits to ensure it's safe for you.
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